9UX1
Cryo-EM structure of the human P2X2/3 heteromer receptor - class 1 (1:2)
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF |
| Chain | Residue | Details |
| A | GLY236-PHE262 | |
| C | GLY259-PHE285 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 556 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 273 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 13 |
| Details | Region: {"description":"Pore-forming motif","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P56373","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
