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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UUX

The complex of human pMEK1 and ERK1 pT202 (ANP)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000187biological_processobsolete activation of MAPK activity
A0003056biological_processregulation of vascular associated smooth muscle contraction
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005078molecular_functionMAP kinase scaffold activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006468biological_processprotein phosphorylation
A0006935biological_processchemotaxis
A0006979biological_processresponse to oxidative stress
A0007165biological_processsignal transduction
A0007528biological_processneuromuscular junction development
A0008285biological_processnegative regulation of cell population proliferation
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0014044biological_processSchwann cell development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030182biological_processneuron differentiation
A0030295molecular_functionprotein kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031267molecular_functionsmall GTPase binding
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0032402biological_processmelanosome transport
A0032839cellular_componentdendrite cytoplasm
A0032872biological_processregulation of stress-activated MAPK cascade
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034111biological_processnegative regulation of homotypic cell-cell adhesion
A0036064cellular_componentciliary basal body
A0038127biological_processERBB signaling pathway
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042552biological_processmyelination
A0043204cellular_componentperikaryon
A0043410biological_processpositive regulation of MAPK cascade
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0045933biological_processpositive regulation of muscle contraction
A0047496biological_processvesicle transport along microtubule
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048313biological_processGolgi inheritance
A0048471cellular_componentperinuclear region of cytoplasm
A0048678biological_processresponse to axon injury
A0048812biological_processneuron projection morphogenesis
A0051384biological_processresponse to glucocorticoid
A0070328biological_processtriglyceride homeostasis
A0070371biological_processERK1 and ERK2 cascade
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090170biological_processregulation of Golgi inheritance
A0090398biological_processcellular senescence
A0097110molecular_functionscaffold protein binding
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0106310molecular_functionprotein serine kinase activity
A1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
A2000641biological_processregulation of early endosome to late endosome transport
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000165biological_processMAPK cascade
B0001784molecular_functionphosphotyrosine residue binding
B0002841biological_processnegative regulation of T cell mediated immune response to tumor cell
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005901cellular_componentcaveola
B0005925cellular_componentfocal adhesion
B0006468biological_processprotein phosphorylation
B0007166biological_processcell surface receptor signaling pathway
B0007173biological_processepidermal growth factor receptor signaling pathway
B0008286biological_processinsulin receptor signaling pathway
B0010759biological_processpositive regulation of macrophage chemotaxis
B0014044biological_processSchwann cell development
B0016310biological_processphosphorylation
B0019233biological_processsensory perception of pain
B0019902molecular_functionphosphatase binding
B0030509biological_processBMP signaling pathway
B0031143cellular_componentpseudopodium
B0031281biological_processpositive regulation of cyclase activity
B0032206biological_processpositive regulation of telomere maintenance
B0032872biological_processregulation of stress-activated MAPK cascade
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0038083biological_processpeptidyl-tyrosine autophosphorylation
B0038133biological_processERBB2-ERBB3 signaling pathway
B0042552biological_processmyelination
B0042770biological_processsignal transduction in response to DNA damage
B0042802molecular_functionidentical protein binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0050804biological_processmodulation of chemical synaptic transmission
B0051403biological_processstress-activated MAPK cascade
B0051493biological_processregulation of cytoskeleton organization
B0061514biological_processinterleukin-34-mediated signaling pathway
B0070371biological_processERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070498biological_processinterleukin-1-mediated signaling pathway
B0070849biological_processresponse to epidermal growth factor
B0071260biological_processcellular response to mechanical stimulus
B0072584biological_processcaveolin-mediated endocytosis
B0090170biological_processregulation of Golgi inheritance
B0090370biological_processnegative regulation of cholesterol efflux
B0098978cellular_componentglutamatergic synapse
B0106310molecular_functionprotein serine kinase activity
B0120041biological_processpositive regulation of macrophage proliferation
B0140297molecular_functionDNA-binding transcription factor binding
B0150078biological_processpositive regulation of neuroinflammatory response
B1904262biological_processnegative regulation of TORC1 signaling
B2000641biological_processregulation of early endosome to late endosome transport
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGNGGVVFkVshkpsglv..........MARK
ChainResidueDetails
ALEU74-LYS97
BILE48-LYS72
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKpsNILV
ChainResidueDetails
AILE186-VAL198
BVAL162-ILE174
site_idPS01351
Number of Residues103
DetailsMAPK MAP kinase signature. FehqtycqrtlREiqillrfrhenvigirdilrastleamrdvyivqdlmetdlykllksqqlsndhicyflyqilrglkyihsanvlh..........RDlKpsnllinttC
ChainResidueDetails
BPHE76-CYS178
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15543157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17880056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18951019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19019675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310613","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Cleavage; by anthrax lethal factor"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"10409742","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PAK","evidences":[{"source":"PubMed","id":"16129686","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"18983981","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19494114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"19060905","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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