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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9UPF

Cryo-EM structure of human olfactory CNG channel in cAMP-bound open state

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0005216molecular_functionmonoatomic ion channel activity
A0005222molecular_functionintracellularly cAMP-activated cation channel activity
A0005223molecular_functionintracellularly cGMP-activated cation channel activity
A0005262molecular_functioncalcium channel activity
A0005516molecular_functioncalmodulin binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006813biological_processpotassium ion transport
A0006814biological_processsodium ion transport
A0006816biological_processcalcium ion transport
A0007606biological_processsensory perception of chemical stimulus
A0007608biological_processsensory perception of smell
A0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
A0030552molecular_functioncAMP binding
A0030553molecular_functioncGMP binding
A0030660cellular_componentGolgi-associated vesicle membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0060170cellular_componentciliary membrane
A0070588biological_processcalcium ion transmembrane transport
A0098655biological_processmonoatomic cation transmembrane transport
A0098804cellular_componentnon-motile cilium membrane
B0000166molecular_functionnucleotide binding
B0001750cellular_componentphotoreceptor outer segment
B0001895biological_processretina homeostasis
B0005222molecular_functionintracellularly cAMP-activated cation channel activity
B0005223molecular_functionintracellularly cGMP-activated cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0006813biological_processpotassium ion transport
B0006814biological_processsodium ion transport
B0006816biological_processcalcium ion transport
B0007186biological_processG protein-coupled receptor signaling pathway
B0007601biological_processvisual perception
B0007608biological_processsensory perception of smell
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
B0021630biological_processolfactory nerve maturation
B0030552molecular_functioncAMP binding
B0030553molecular_functioncGMP binding
B0030660cellular_componentGolgi-associated vesicle membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0043195cellular_componentterminal bouton
B0043855molecular_functioncyclic nucleotide-activated monoatomic ion channel activity
B0044877molecular_functionprotein-containing complex binding
B0050908biological_processdetection of light stimulus involved in visual perception
B0050911biological_processdetection of chemical stimulus involved in sensory perception of smell
B0051480biological_processregulation of cytosolic calcium ion concentration
B0051899biological_processmembrane depolarization
B0060170cellular_componentciliary membrane
B0070588biological_processcalcium ion transmembrane transport
B0098655biological_processmonoatomic cation transmembrane transport
B0098804cellular_componentnon-motile cilium membrane
B0120200cellular_componentrod photoreceptor outer segment
B1902495cellular_componenttransmembrane transporter complex
B1990834biological_processresponse to odorant
C0000166molecular_functionnucleotide binding
C0005216molecular_functionmonoatomic ion channel activity
C0005222molecular_functionintracellularly cAMP-activated cation channel activity
C0005223molecular_functionintracellularly cGMP-activated cation channel activity
C0005262molecular_functioncalcium channel activity
C0005516molecular_functioncalmodulin binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006813biological_processpotassium ion transport
C0006814biological_processsodium ion transport
C0006816biological_processcalcium ion transport
C0007606biological_processsensory perception of chemical stimulus
C0007608biological_processsensory perception of smell
C0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
C0030552molecular_functioncAMP binding
C0030553molecular_functioncGMP binding
C0030660cellular_componentGolgi-associated vesicle membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0060170cellular_componentciliary membrane
C0070588biological_processcalcium ion transmembrane transport
C0098655biological_processmonoatomic cation transmembrane transport
C0098804cellular_componentnon-motile cilium membrane
D0000166molecular_functionnucleotide binding
D0005222molecular_functionintracellularly cAMP-activated cation channel activity
D0005223molecular_functionintracellularly cGMP-activated cation channel activity
D0005262molecular_functioncalcium channel activity
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006813biological_processpotassium ion transport
D0006814biological_processsodium ion transport
D0006816biological_processcalcium ion transport
D0007606biological_processsensory perception of chemical stimulus
D0007608biological_processsensory perception of smell
D0017071cellular_componentintracellular cyclic nucleotide activated cation channel complex
D0030552molecular_functioncAMP binding
D0030553molecular_functioncGMP binding
D0030660cellular_componentGolgi-associated vesicle membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0060170cellular_componentciliary membrane
D0070588biological_processcalcium ion transmembrane transport
D0098655biological_processmonoatomic cation transmembrane transport
D0098804cellular_componentnon-motile cilium membrane
Functional Information from PROSITE/UniProt
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrKGDiGKeMYIIkeG
ChainResidueDetails
AILE481-GLY497
BVAL989-GLY1005
DVAL375-GLY391
site_idPS00889
Number of Residues24
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEiSIlnikgskmgnrRTAnIrS
ChainResidueDetails
APHE519-SER542
BPHE1028-ALA1048
DPHE413-SER436
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues135
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues115
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues26
DetailsTransmembrane: {"description":"Helical; Name=P-helix","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues25
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RH9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues99
DetailsRegion: {"description":"Ion conduction pathway","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues76
DetailsRegion: {"description":"C-linker","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues116
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7RHI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7RHH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsSite: {"description":"Central gate","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Occludes the pore below the central gate","evidences":[{"source":"PubMed","id":"34699778","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues69
DetailsTransmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues102
DetailsTransmembrane: {"description":"Helical; Name=P-helix","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues72
DetailsTransmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues324
DetailsRegion: {"description":"Ion conduction pathway","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues9
DetailsRegion: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues228
DetailsRegion: {"description":"C-linker","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues360
DetailsRegion: {"description":"Cyclic nucleotide-binding domain","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues5
DetailsSite: {"description":"Central gate","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"P29973","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues10
DetailsMotif: {"description":"IQ-type"}
ChainResidueDetails

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PDB entries from 2025-12-03

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