9UOK
Structure of the complex of LGR4_ECD with Norrin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0005109 | molecular_function | frizzled binding |
| E | 0005125 | molecular_function | cytokine activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005615 | cellular_component | extracellular space |
| E | 0007033 | biological_process | vacuole organization |
| E | 0007399 | biological_process | nervous system development |
| E | 0007601 | biological_process | visual perception |
| E | 0009986 | cellular_component | cell surface |
| E | 0016055 | biological_process | Wnt signaling pathway |
| E | 0035426 | biological_process | extracellular matrix-cell signaling |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| E | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| E | 0046697 | biological_process | decidualization |
| E | 0110135 | biological_process | Norrin signaling pathway |
| F | 0005109 | molecular_function | frizzled binding |
| F | 0005125 | molecular_function | cytokine activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| F | 0007033 | biological_process | vacuole organization |
| F | 0007399 | biological_process | nervous system development |
| F | 0007601 | biological_process | visual perception |
| F | 0009986 | cellular_component | cell surface |
| F | 0016055 | biological_process | Wnt signaling pathway |
| F | 0035426 | biological_process | extracellular matrix-cell signaling |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| F | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| F | 0046697 | biological_process | decidualization |
| F | 0110135 | biological_process | Norrin signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 22 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cdc..CesfLltkpvsckHliks.H |
| Chain | Residue | Details |
| C | CYS858-HIS879 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FSCSVMH |
| Chain | Residue | Details |
| E | PHE363-HIS369 |
| site_id | PS01185 |
| Number of Residues | 37 |
| Details | CTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C |
| Chain | Residue | Details |
| E | CYS95-CYS131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 23 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 21 |
| Details | Repeat: {"description":"LRR 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"23756652","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 93 |
| Details | Domain: {"description":"CTCK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00039","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
