Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9UHS

Complete a6b6 of ATP-bound hPCC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004658	molecular_function	propionyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009374	molecular_function	biotin binding
A	0016042	biological_process	lipid catabolic process
A	0016874	molecular_function	ligase activity
A	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
A	0019626	biological_process	short-chain fatty acid catabolic process
A	0019899	molecular_function	enzyme binding
A	0046872	molecular_function	metal ion binding
A	1901290	biological_process	succinyl-CoA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004658	molecular_function	propionyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009374	molecular_function	biotin binding
C	0016042	biological_process	lipid catabolic process
C	0016874	molecular_function	ligase activity
C	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
C	0019626	biological_process	short-chain fatty acid catabolic process
C	0019899	molecular_function	enzyme binding
C	0046872	molecular_function	metal ion binding
C	1901290	biological_process	succinyl-CoA biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0004658	molecular_function	propionyl-CoA carboxylase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0009081	biological_process	branched-chain amino acid metabolic process
H	0009374	molecular_function	biotin binding
H	0016042	biological_process	lipid catabolic process
H	0016874	molecular_function	ligase activity
H	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
H	0019626	biological_process	short-chain fatty acid catabolic process
H	0019899	molecular_function	enzyme binding
H	0046872	molecular_function	metal ion binding
H	1901290	biological_process	succinyl-CoA biosynthetic process
K	0000166	molecular_function	nucleotide binding
K	0004658	molecular_function	propionyl-CoA carboxylase activity
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0009081	biological_process	branched-chain amino acid metabolic process
K	0009374	molecular_function	biotin binding
K	0016042	biological_process	lipid catabolic process
K	0016874	molecular_function	ligase activity
K	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
K	0019626	biological_process	short-chain fatty acid catabolic process
K	0019899	molecular_function	enzyme binding
K	0046872	molecular_function	metal ion binding
K	1901290	biological_process	succinyl-CoA biosynthetic process
O	0000166	molecular_function	nucleotide binding
O	0004658	molecular_function	propionyl-CoA carboxylase activity
O	0005515	molecular_function	protein binding
O	0005524	molecular_function	ATP binding
O	0005739	cellular_component	mitochondrion
O	0005759	cellular_component	mitochondrial matrix
O	0005829	cellular_component	cytosol
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0009081	biological_process	branched-chain amino acid metabolic process
O	0009374	molecular_function	biotin binding
O	0016042	biological_process	lipid catabolic process
O	0016874	molecular_function	ligase activity
O	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
O	0019626	biological_process	short-chain fatty acid catabolic process
O	0019899	molecular_function	enzyme binding
O	0046872	molecular_function	metal ion binding
O	1901290	biological_process	succinyl-CoA biosynthetic process
R	0000166	molecular_function	nucleotide binding
R	0004658	molecular_function	propionyl-CoA carboxylase activity
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005739	cellular_component	mitochondrion
R	0005759	cellular_component	mitochondrial matrix
R	0005829	cellular_component	cytosol
R	0006629	biological_process	lipid metabolic process
R	0006631	biological_process	fatty acid metabolic process
R	0009081	biological_process	branched-chain amino acid metabolic process
R	0009374	molecular_function	biotin binding
R	0016042	biological_process	lipid catabolic process
R	0016874	molecular_function	ligase activity
R	0016885	molecular_function	ligase activity, forming carbon-carbon bonds
R	0019626	biological_process	short-chain fatty acid catabolic process
R	0019899	molecular_function	enzyme binding
R	0046872	molecular_function	metal ion binding
R	1901290	biological_process	succinyl-CoA biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQeIcvIeAMKMqnsMtA

Chain	Residue	Details
A	GLY684-ALA701

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASaggGGkG

Chain	Residue	Details
A	TYR214-GLY228

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLEMNTRL

Chain	Residue	Details
A	PHE347-LEU354

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2682
Details	Domain: {"description":"Biotin carboxylation","evidences":[{"source":"PROSITE-ProRule","id":"PRU00969","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1182
Details	Domain: {"description":"ATP-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	450
Details	Domain: {"description":"Biotinyl-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	18
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	384
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5LUF3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	24
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91ZA3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	6
Details	Modified residue: {"description":"N6-biotinyllysine; by HLCS","evidences":[{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20443544","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1434
Details	Domain: {"description":"CoA carboxyltransferase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01137","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	198
Details	Region: {"description":"Acyl-CoA binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	18
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99MN9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1548
Details	Domain: {"description":"CoA carboxyltransferase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99MN9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)