9U4L

Fibril structure of human alphaA-crystallin with pathogenic mutation R116C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002088	biological_process	lens development in camera-type eye
A	0005198	molecular_function	structural molecule activity
A	0005212	molecular_function	structural constituent of eye lens
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007601	biological_process	visual perception
A	0009408	biological_process	response to heat
A	0032387	biological_process	negative regulation of intracellular transport
A	0032991	cellular_component	protein-containing complex
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0046872	molecular_function	metal ion binding
A	0050821	biological_process	protein stabilization
A	0051082	molecular_function	unfolded protein binding
B	0002088	biological_process	lens development in camera-type eye
B	0005198	molecular_function	structural molecule activity
B	0005212	molecular_function	structural constituent of eye lens
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007601	biological_process	visual perception
B	0009408	biological_process	response to heat
B	0032387	biological_process	negative regulation of intracellular transport
B	0032991	cellular_component	protein-containing complex
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0050821	biological_process	protein stabilization
B	0051082	molecular_function	unfolded protein binding
C	0002088	biological_process	lens development in camera-type eye
C	0005198	molecular_function	structural molecule activity
C	0005212	molecular_function	structural constituent of eye lens
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007601	biological_process	visual perception
C	0009408	biological_process	response to heat
C	0032387	biological_process	negative regulation of intracellular transport
C	0032991	cellular_component	protein-containing complex
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0046872	molecular_function	metal ion binding
C	0050821	biological_process	protein stabilization
C	0051082	molecular_function	unfolded protein binding
D	0002088	biological_process	lens development in camera-type eye
D	0005198	molecular_function	structural molecule activity
D	0005212	molecular_function	structural constituent of eye lens
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007601	biological_process	visual perception
D	0009408	biological_process	response to heat
D	0032387	biological_process	negative regulation of intracellular transport
D	0032991	cellular_component	protein-containing complex
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0046872	molecular_function	metal ion binding
D	0050821	biological_process	protein stabilization
D	0051082	molecular_function	unfolded protein binding
E	0002088	biological_process	lens development in camera-type eye
E	0005198	molecular_function	structural molecule activity
E	0005212	molecular_function	structural constituent of eye lens
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007601	biological_process	visual perception
E	0009408	biological_process	response to heat
E	0032387	biological_process	negative regulation of intracellular transport
E	0032991	cellular_component	protein-containing complex
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0046872	molecular_function	metal ion binding
E	0050821	biological_process	protein stabilization
E	0051082	molecular_function	unfolded protein binding
F	0002088	biological_process	lens development in camera-type eye
F	0005198	molecular_function	structural molecule activity
F	0005212	molecular_function	structural constituent of eye lens
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007601	biological_process	visual perception
F	0009408	biological_process	response to heat
F	0032387	biological_process	negative regulation of intracellular transport
F	0032991	cellular_component	protein-containing complex
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0046872	molecular_function	metal ion binding
F	0050821	biological_process	protein stabilization
F	0051082	molecular_function	unfolded protein binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Site: {"description":"Susceptible to oxidation"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Deamidated glutamine; partial","evidences":[{"source":"PubMed","id":"9068373","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22120592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9655350","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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