9U4J
Cryo-EM structure of the hGPR4-apo Receptor in pH 7.8
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ISIaFLCCISVDRYLaV |
| Chain | Residue | Details |
| A | ILE103-VAL119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 26 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 37 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 35 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215959","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"40215960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9BIP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 15 |
| Details | Region: {"description":"Extracellular loop 2 (ECL2)","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for activation","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Site: {"description":"Proton sensing","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Site: {"description":"Proton sensing","evidences":[{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Site: {"description":"Proton sensing","evidences":[{"source":"PubMed","id":"39753132","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"40211064","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
