9U3U

Cryo-EM structure of human AC9_delC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001701	biological_process	in utero embryonic development
A	0003091	biological_process	renal water homeostasis
A	0004016	molecular_function	adenylate cyclase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006171	biological_process	cAMP biosynthetic process
A	0007165	biological_process	signal transduction
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0016829	molecular_function	lyase activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0036064	cellular_component	ciliary basal body
A	0046872	molecular_function	metal ion binding
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071880	biological_process	adenylate cyclase-activating adrenergic receptor signaling pathway
A	0097700	biological_process	vascular endothelial cell response to laminar fluid shear stress

Functional Information from PROSITE/UniProt

site_id	PS00452
Number of Residues	24
Details	GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GIL.GmrrfkFdVWSNDVNlanlmE

Chain	Residue	Details
A	GLY498-GLU521
A	GLY1175-ASP1198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	47
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	127
Details	Domain: {"description":"Guanylate cyclase 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P26769","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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