9TU0

Crystal structure of human ERK1 in complex with the KIM1 motif of the T. gondii protein GRA24

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001784	molecular_function	phosphotyrosine residue binding
A	0002841	biological_process	negative regulation of T cell mediated immune response to tumor cell
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0005925	cellular_component	focal adhesion
A	0006468	biological_process	protein phosphorylation
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0008286	biological_process	insulin receptor signaling pathway
A	0010759	biological_process	positive regulation of macrophage chemotaxis
A	0014044	biological_process	Schwann cell development
A	0016310	biological_process	phosphorylation
A	0019233	biological_process	sensory perception of pain
A	0019902	molecular_function	phosphatase binding
A	0030509	biological_process	BMP signaling pathway
A	0031143	cellular_component	pseudopodium
A	0031281	biological_process	positive regulation of cyclase activity
A	0032206	biological_process	positive regulation of telomere maintenance
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0034198	biological_process	cellular response to amino acid starvation
A	0035556	biological_process	intracellular signal transduction
A	0038083	biological_process	peptidyl-tyrosine autophosphorylation
A	0038133	biological_process	ERBB2-ERBB3 signaling pathway
A	0042552	biological_process	myelination
A	0042770	biological_process	signal transduction in response to DNA damage
A	0042802	molecular_function	identical protein binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0048009	biological_process	insulin-like growth factor receptor signaling pathway
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051403	biological_process	stress-activated MAPK cascade
A	0051493	biological_process	regulation of cytoskeleton organization
A	0061514	biological_process	interleukin-34-mediated signaling pathway
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0070498	biological_process	interleukin-1-mediated signaling pathway
A	0070849	biological_process	response to epidermal growth factor
A	0071260	biological_process	cellular response to mechanical stimulus
A	0072584	biological_process	caveolin-mediated endocytosis
A	0090170	biological_process	regulation of Golgi inheritance
A	0090370	biological_process	negative regulation of cholesterol efflux
A	0097542	cellular_component	ciliary tip
A	0098978	cellular_component	glutamatergic synapse
A	0106310	molecular_function	protein serine kinase activity
A	0120041	biological_process	positive regulation of macrophage proliferation
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0150078	biological_process	positive regulation of neuroinflammatory response
A	1904262	biological_process	negative regulation of TORC1 signaling
A	2000641	biological_process	regulation of early endosome to late endosome transport

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVSsAydhvrktrv.........AIKK

Chain	Residue	Details
A	ILE48-LYS72

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLI

Chain	Residue	Details
A	VAL162-ILE174

---

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FehqtycqrtlREiqillrfrhenvigirdilrastleamrdvyivqdlmetdlykllksqqlsndhicyflyqilrglkyihsanvlh..........RDlKpsnllinttC

Chain	Residue	Details
A	PHE76-CYS178

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---