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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9TQD

CD163 bound to haemoglobin

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
D0004601molecular_functionperoxidase activity
D0005344molecular_functionoxygen carrier activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005829cellular_componentcytosol
D0005833cellular_componenthemoglobin complex
D0006954biological_processinflammatory response
D0015670biological_processcarbon dioxide transport
D0015671biological_processoxygen transport
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0030185biological_processnitric oxide transport
D0031720molecular_functionhaptoglobin binding
D0031838cellular_componenthaptoglobin-hemoglobin complex
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0048821biological_processerythrocyte development
D0070062cellular_componentextracellular exosome
D0071682cellular_componentendocytic vesicle lumen
D0072562cellular_componentblood microparticle
D0098869biological_processcellular oxidant detoxification
E0004601molecular_functionperoxidase activity
E0005344molecular_functionoxygen carrier activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005829cellular_componentcytosol
E0005833cellular_componenthemoglobin complex
E0006954biological_processinflammatory response
E0015670biological_processcarbon dioxide transport
E0015671biological_processoxygen transport
E0019825molecular_functionoxygen binding
E0020037molecular_functionheme binding
E0030185biological_processnitric oxide transport
E0030492molecular_functionhemoglobin binding
E0031720molecular_functionhaptoglobin binding
E0031721molecular_functionhemoglobin alpha binding
E0031838cellular_componenthaptoglobin-hemoglobin complex
E0042542biological_processresponse to hydrogen peroxide
E0042744biological_processhydrogen peroxide catabolic process
E0045429biological_processpositive regulation of nitric oxide biosynthetic process
E0048821biological_processerythrocyte development
E0070062cellular_componentextracellular exosome
E0070293biological_processrenal absorption
E0070527biological_processplatelet aggregation
E0071682cellular_componentendocytic vesicle lumen
E0072562cellular_componentblood microparticle
E0098869biological_processcellular oxidant detoxification
E1904724cellular_componenttertiary granule lumen
E1904813cellular_componentficolin-1-rich granule lumen
F0004601molecular_functionperoxidase activity
F0005344molecular_functionoxygen carrier activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005829cellular_componentcytosol
F0005833cellular_componenthemoglobin complex
F0006954biological_processinflammatory response
F0015670biological_processcarbon dioxide transport
F0015671biological_processoxygen transport
F0016020cellular_componentmembrane
F0020037molecular_functionheme binding
F0030185biological_processnitric oxide transport
F0031720molecular_functionhaptoglobin binding
F0031838cellular_componenthaptoglobin-hemoglobin complex
F0042542biological_processresponse to hydrogen peroxide
F0042744biological_processhydrogen peroxide catabolic process
F0048821biological_processerythrocyte development
F0070062cellular_componentextracellular exosome
F0071682cellular_componentendocytic vesicle lumen
F0072562cellular_componentblood microparticle
F0098869biological_processcellular oxidant detoxification
G0004601molecular_functionperoxidase activity
G0005344molecular_functionoxygen carrier activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005829cellular_componentcytosol
G0005833cellular_componenthemoglobin complex
G0006954biological_processinflammatory response
G0015670biological_processcarbon dioxide transport
G0015671biological_processoxygen transport
G0019825molecular_functionoxygen binding
G0020037molecular_functionheme binding
G0030185biological_processnitric oxide transport
G0030492molecular_functionhemoglobin binding
G0031720molecular_functionhaptoglobin binding
G0031721molecular_functionhemoglobin alpha binding
G0031838cellular_componenthaptoglobin-hemoglobin complex
G0042542biological_processresponse to hydrogen peroxide
G0042744biological_processhydrogen peroxide catabolic process
G0045429biological_processpositive regulation of nitric oxide biosynthetic process
G0048821biological_processerythrocyte development
G0070062cellular_componentextracellular exosome
G0070293biological_processrenal absorption
G0070527biological_processplatelet aggregation
G0071682cellular_componentendocytic vesicle lumen
G0072562cellular_componentblood microparticle
G0098869biological_processcellular oxidant detoxification
G1904724cellular_componenttertiary granule lumen
G1904813cellular_componentficolin-1-rich granule lumen
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues200
DetailsDomain: {"description":"SRCR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues300
DetailsDomain: {"description":"SRCR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues300
DetailsDomain: {"description":"SRCR 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues300
DetailsDomain: {"description":"SRCR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues300
DetailsDomain: {"description":"SRCR 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues300
DetailsDomain: {"description":"SRCR 7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues306
DetailsDomain: {"description":"SRCR 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues300
DetailsDomain: {"description":"SRCR 9","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsSite: {"description":"Cleavage; in calcium-free condition"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues7
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues101
DetailsDomain: {"description":"SRCR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsPeptide: {"description":"Hemopressin","featureId":"PRO_0000455882","evidences":[{"source":"PubMed","id":"18077343","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsBinding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues66
DetailsSite: {"description":"(Microbial infection) Cleavage; by N.americanus apr-2","evidences":[{"source":"PubMed","id":"12552433","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues16
DetailsSite: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P01942","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues10
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"7358733","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues18
DetailsPeptide: {"description":"LVV-hemorphin-7","featureId":"PRO_0000296641"}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues12
DetailsPeptide: {"description":"Spinorphin","featureId":"PRO_0000424226"}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues8
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsBinding site: {"description":"distal binding residue"}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues2
DetailsBinding site: {"description":"proximal binding residue"}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsModified residue: {"description":"N-pyruvate 2-iminyl-valine; in Hb A1b"}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsModified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"8637569","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9843411","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"4531009","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) valine; in Hb A1c","evidences":[{"source":"PubMed","id":"635569","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-05-27

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