Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9T6H

Cryo-EM structure of the 70S ribosome from Francisella tularensis bound to antibiotics chloramphenicol and gentamicin

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0006412	biological_process	translation
1	0003735	molecular_function	structural constituent of ribosome
1	0005737	cellular_component	cytoplasm
1	0006412	biological_process	translation
1	0015934	cellular_component	large ribosomal subunit
1	0019843	molecular_function	rRNA binding
1	0022625	cellular_component	cytosolic large ribosomal subunit
2	0006412	biological_process	translation
3	0003735	molecular_function	structural constituent of ribosome
3	0006412	biological_process	translation
3	0015934	cellular_component	large ribosomal subunit
3	0022625	cellular_component	cytosolic large ribosomal subunit
4	0005737	cellular_component	cytoplasm
4	0006412	biological_process	translation
4	0008270	molecular_function	zinc ion binding
4	0019843	molecular_function	rRNA binding
9	0022627	cellular_component	cytosolic small ribosomal subunit
9	0043024	molecular_function	ribosomal small subunit binding
9	0045900	biological_process	negative regulation of translational elongation
b	0003735	molecular_function	structural constituent of ribosome
b	0006412	biological_process	translation
b	0022627	cellular_component	cytosolic small ribosomal subunit
c	0003729	molecular_function	mRNA binding
c	0003735	molecular_function	structural constituent of ribosome
c	0006412	biological_process	translation
c	0019843	molecular_function	rRNA binding
c	0022627	cellular_component	cytosolic small ribosomal subunit
C	0002181	biological_process	cytoplasmic translation
C	0003723	molecular_function	RNA binding
C	0003735	molecular_function	structural constituent of ribosome
C	0006412	biological_process	translation
C	0015934	cellular_component	large ribosomal subunit
C	0019843	molecular_function	rRNA binding
d	0003735	molecular_function	structural constituent of ribosome
d	0006412	biological_process	translation
d	0015935	cellular_component	small ribosomal subunit
d	0019843	molecular_function	rRNA binding
d	0042274	biological_process	ribosomal small subunit biogenesis
D	0003735	molecular_function	structural constituent of ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
e	0005737	cellular_component	cytoplasm
e	0006412	biological_process	translation
e	0019843	molecular_function	rRNA binding
e	0042254	biological_process	ribosome biogenesis
E	0003735	molecular_function	structural constituent of ribosome
E	0006412	biological_process	translation
E	0019843	molecular_function	rRNA binding
f	0003735	molecular_function	structural constituent of ribosome
f	0005737	cellular_component	cytoplasm
f	0006412	biological_process	translation
f	0015935	cellular_component	small ribosomal subunit
f	0019843	molecular_function	rRNA binding
f	0022627	cellular_component	cytosolic small ribosomal subunit
f	0070181	molecular_function	small ribosomal subunit rRNA binding
F	0000049	molecular_function	tRNA binding
F	0006412	biological_process	translation
F	0019843	molecular_function	rRNA binding
g	0000049	molecular_function	tRNA binding
g	0006412	biological_process	translation
g	0019843	molecular_function	rRNA binding
G	0002181	biological_process	cytoplasmic translation
G	0003735	molecular_function	structural constituent of ribosome
G	0006412	biological_process	translation
G	0019843	molecular_function	rRNA binding
G	0022625	cellular_component	cytosolic large ribosomal subunit
h	0005737	cellular_component	cytoplasm
h	0006412	biological_process	translation
h	0019843	molecular_function	rRNA binding
H	0006412	biological_process	translation
H	0019843	molecular_function	rRNA binding
i	0003723	molecular_function	RNA binding
i	0003735	molecular_function	structural constituent of ribosome
i	0005737	cellular_component	cytoplasm
i	0006412	biological_process	translation
i	0015935	cellular_component	small ribosomal subunit
i	0022627	cellular_component	cytosolic small ribosomal subunit
I	0003729	molecular_function	mRNA binding
I	0003735	molecular_function	structural constituent of ribosome
I	0005840	cellular_component	ribosome
I	0006412	biological_process	translation
I	0017148	biological_process	negative regulation of translation
I	0022625	cellular_component	cytosolic large ribosomal subunit
j	0000049	molecular_function	tRNA binding
j	0005737	cellular_component	cytoplasm
j	0006412	biological_process	translation
J	0003735	molecular_function	structural constituent of ribosome
J	0006412	biological_process	translation
J	0019843	molecular_function	rRNA binding
J	0022625	cellular_component	cytosolic large ribosomal subunit
J	0070180	molecular_function	large ribosomal subunit rRNA binding
k	0006412	biological_process	translation
k	0019843	molecular_function	rRNA binding
K	0003735	molecular_function	structural constituent of ribosome
K	0006412	biological_process	translation
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
l	0000049	molecular_function	tRNA binding
l	0006412	biological_process	translation
l	0019843	molecular_function	rRNA binding
m	0000049	molecular_function	tRNA binding
m	0005829	cellular_component	cytosol
m	0006412	biological_process	translation
m	0015935	cellular_component	small ribosomal subunit
m	0019843	molecular_function	rRNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0006412	biological_process	translation
M	0015934	cellular_component	large ribosomal subunit
M	0022625	cellular_component	cytosolic large ribosomal subunit
n	0003735	molecular_function	structural constituent of ribosome
n	0006412	biological_process	translation
n	0015935	cellular_component	small ribosomal subunit
n	0019843	molecular_function	rRNA binding
N	0005737	cellular_component	cytoplasm
N	0006412	biological_process	translation
N	0008097	molecular_function	5S rRNA binding
N	0019843	molecular_function	rRNA binding
N	0022625	cellular_component	cytosolic large ribosomal subunit
o	0005737	cellular_component	cytoplasm
o	0006412	biological_process	translation
o	0019843	molecular_function	rRNA binding
o	0022627	cellular_component	cytosolic small ribosomal subunit
O	0003735	molecular_function	structural constituent of ribosome
O	0006412	biological_process	translation
O	0022625	cellular_component	cytosolic large ribosomal subunit
p	0003735	molecular_function	structural constituent of ribosome
p	0005737	cellular_component	cytoplasm
p	0006412	biological_process	translation
p	0015935	cellular_component	small ribosomal subunit
P	0000027	biological_process	ribosomal large subunit assembly
P	0019843	molecular_function	rRNA binding
q	0003735	molecular_function	structural constituent of ribosome
q	0006412	biological_process	translation
q	0019843	molecular_function	rRNA binding
q	0022627	cellular_component	cytosolic small ribosomal subunit
Q	0003735	molecular_function	structural constituent of ribosome
Q	0005737	cellular_component	cytoplasm
Q	0006412	biological_process	translation
Q	0019843	molecular_function	rRNA binding
r	0003735	molecular_function	structural constituent of ribosome
r	0006412	biological_process	translation
r	0019843	molecular_function	rRNA binding
r	0022627	cellular_component	cytosolic small ribosomal subunit
r	0070181	molecular_function	small ribosomal subunit rRNA binding
R	0003735	molecular_function	structural constituent of ribosome
R	0006412	biological_process	translation
R	0015934	cellular_component	large ribosomal subunit
R	0019843	molecular_function	rRNA binding
R	0022625	cellular_component	cytosolic large ribosomal subunit
s	0000028	biological_process	ribosomal small subunit assembly
s	0003735	molecular_function	structural constituent of ribosome
s	0005737	cellular_component	cytoplasm
s	0006412	biological_process	translation
s	0019843	molecular_function	rRNA binding
S	0006412	biological_process	translation
S	0019843	molecular_function	rRNA binding
t	0005829	cellular_component	cytosol
t	0006412	biological_process	translation
t	0015935	cellular_component	small ribosomal subunit
t	0019843	molecular_function	rRNA binding
t	0070181	molecular_function	small ribosomal subunit rRNA binding
T	0006412	biological_process	translation
T	0019843	molecular_function	rRNA binding
u	0006412	biological_process	translation
U	0003723	molecular_function	RNA binding
U	0006412	biological_process	translation
U	0008097	molecular_function	5S rRNA binding
U	0022625	cellular_component	cytosolic large ribosomal subunit
V	0003735	molecular_function	structural constituent of ribosome
V	0006412	biological_process	translation
V	0022625	cellular_component	cytosolic large ribosomal subunit
V	0043022	molecular_function	ribosome binding
V	1902626	biological_process	assembly of large subunit precursor of preribosome
W	0003735	molecular_function	structural constituent of ribosome
W	0006412	biological_process	translation
W	0019843	molecular_function	rRNA binding
W	0022625	cellular_component	cytosolic large ribosomal subunit
X	0006412	biological_process	translation
X	0022625	cellular_component	cytosolic large ribosomal subunit
Y	0006412	biological_process	translation
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Z	0006412	biological_process	translation

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtakgvrrk.DGskvrFdgNaaVL

Chain	Residue	Details
J	ALA60-LEU86

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVKLAeghdinfV

Chain	Residue	Details
S	LYS81-VAL96

site_id	PS00052
Number of Residues	27
Details	RIBOSOMAL_S7 Ribosomal protein S7 signature. SqVvakFVnhimlsGKKsiaekIVygA

Chain	Residue	Details
g	SER20-ALA46

site_id	PS00053
Number of Residues	18
Details	RIBOSOMAL_S8 Ribosomal protein S8 signature. GvaIVSTSkGLVsdrkAR

Chain	Residue	Details
h	GLY102-ARG119

site_id	PS00054
Number of Residues	23
Details	RIBOSOMAL_S11 Ribosomal protein S11 signature. IrALn.AkNLkVtsitDvTPlPHN

Chain	Residue	Details
k	ILE97-ASN119

site_id	PS00055
Number of Residues	8
Details	RIBOSOMAL_S12 Ribosomal protein S12 signature. KkPNSAlR

Chain	Residue	Details
l	LYS43-ARG50

site_id	PS00057
Number of Residues	24
Details	RIBOSOMAL_S18 Ribosomal protein S18 signature. IDYkd.VnkLkaYINEt.GKIvpsRV

Chain	Residue	Details
r	ILE17-VAL40

site_id	PS00323
Number of Residues	25
Details	RIBOSOMAL_S19 Ribosomal protein S19 signature. NGQqhvpvlMteemVGhkLGEFvvT

Chain	Residue	Details
s	ASN53-THR77

site_id	PS00358
Number of Residues	17
Details	RIBOSOMAL_L5 Ribosomal protein L5 signature. LtaIAGQkpVvTkSKkS

Chain	Residue	Details
F	LEU57-SER73

site_id	PS00360
Number of Residues	19
Details	RIBOSOMAL_S9 Ribosomal protein S9 signature. GGGttGQagAirlGvTRAL

Chain	Residue	Details
i	GLY68-LEU86

site_id	PS00362
Number of Residues	31
Details	RIBOSOMAL_S15 Ribosomal protein S15 signature. LkgHFeahKkDnhSrrgLlrLvsqrrkLldY

Chain	Residue	Details
o	LEU38-TYR68

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KrfEaRAkGRgnrilkrtSHITVkV

Chain	Residue	Details
R	LYS83-VAL107

site_id	PS00467
Number of Residues	12
Details	RIBOSOMAL_L2 Ribosomal protein L2 signature. PtvRGVAmNPvD

Chain	Residue	Details
C	PRO219-ASP230

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FeagqkvDvrGvSkGKGfqGgvkR

Chain	Residue	Details
D	PHE102-ARG125

site_id	PS00475
Number of Residues	31
Details	RIBOSOMAL_L15 Ribosomal protein L15 signature. KVIAsGeIqka..VsLkgiaCTkgAkeaIekaG

Chain	Residue	Details
K	LYS109-GLY139

site_id	PS00525
Number of Residues	9
Details	RIBOSOMAL_L6_1 Ribosomal protein L6 signature 1. PEpYKGKGV

Chain	Residue	Details
G	PRO155-VAL163

site_id	PS00527
Number of Residues	24
Details	RIBOSOMAL_S14 Ribosomal protein S14 signature. RrCkvtgrphavyrkFGLCRnKLR

Chain	Residue	Details
n	ARG62-ARG85

site_id	PS00548
Number of Residues	35
Details	RIBOSOMAL_S3 Ribosomal protein S3 signature. ARsewardGrVplQt..FradVDyataealTtyGviG

Chain	Residue	Details
c	ALA163-GLY197

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. KNHLFKsAKRDIARI

Chain	Residue	Details
X	LYS43-ILE57

site_id	PS00582
Number of Residues	20
Details	RIBOSOMAL_L33 Ribosomal protein L33 signature. YtTtKNkkemPnkMEikKYD

Chain	Residue	Details
1	TYR17-ASP36

site_id	PS00585
Number of Residues	33
Details	RIBOSOMAL_S5 Ribosomal protein S5 signature. GRimsFaAltVVGDgk.GrIGvGrgksr.EVpa.AI

Chain	Residue	Details
e	GLY28-ILE60

site_id	PS00586
Number of Residues	12
Details	RIBOSOMAL_L16_1 Ribosomal protein L16 signature 1. KRgGKIWIRIFP

Chain	Residue	Details
L	LYS59-PRO70

site_id	PS00632
Number of Residues	25
Details	RIBOSOMAL_S4 Ribosomal protein S4 signature. LEsRLdnvVYRmgfAaTraeARqLV

Chain	Residue	Details
d	LEU94-VAL118

site_id	PS00646
Number of Residues	14
Details	RIBOSOMAL_S13_1 Ribosomal protein S13 signature. RGrRHrrSlpVRGQ

Chain	Residue	Details
m	ARG87-GLN100

site_id	PS00651
Number of Residues	28
Details	RIBOSOMAL_L9 Ribosomal protein L9 signature. GvlGdivnVkpGYarNFLipfgkAvqaT

Chain	Residue	Details
H	GLY13-THR40

site_id	PS00701
Number of Residues	12
Details	RIBOSOMAL_L16_2 Ribosomal protein L16 signature 2. RMGkGKGsveyW

Chain	Residue	Details
L	ARG82-TRP93

site_id	PS00783
Number of Residues	23
Details	RIBOSOMAL_L13 Ribosomal protein L13 signature. VRGMLPrtpl.GRtmfkkLkVYaG

Chain	Residue	Details
I	VAL105-GLY127

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsnlkRkrth.GFraR

Chain	Residue	Details
2	LYS2-ARG21

site_id	PS00828
Number of Residues	26
Details	RIBOSOMAL_L36 Ribosomal protein L36 signature. CrnCkvIkRnrvVrViCtdp.RHkQrQ

Chain	Residue	Details
4	CYS11-GLN36

site_id	PS00831
Number of Residues	15
Details	RIBOSOMAL_L27 Ribosomal protein L27 signature. GtIIiRQRGtkthpG

Chain	Residue	Details
V	GLY34-GLY48

site_id	PS00936
Number of Residues	27
Details	RIBOSOMAL_L35 Ribosomal protein L35 signature. KTKsGAaKRFkktgkggfkhrcanr.AH

Chain	Residue	Details
3	LYS5-HIS31

site_id	PS00937
Number of Residues	17
Details	RIBOSOMAL_L20 Ribosomal protein L20 signature. KrtfRsLWIVRINaaaR

Chain	Residue	Details
P	LYS54-ARG70

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. MkEMLSAGVHFG

Chain	Residue	Details
b	MET4-GLY15

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VeKrADVR.RAKLYYMR

Chain	Residue	Details
O	VAL87-ARG102

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. GDdViVIaGkdKGrr.GvV

Chain	Residue	Details
T	GLY7-VAL24

site_id	PS01143
Number of Residues	22
Details	RIBOSOMAL_L31 Ribosomal protein L31 signature. DIcsecHPFYTgkqrivdta....GR

Chain	Residue	Details
Z	ASP36-ARG57

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IkTTlpKaKelrtivEpLVTlAK

Chain	Residue	Details
M	ILE34-LYS56

site_id	PS01169
Number of Residues	23
Details	RIBOSOMAL_L21 Ribosomal protein L21 signature. VkimKfrrRKhsmkqqGHRQyfT

Chain	Residue	Details
Q	VAL73-THR95

site_id	PS01181
Number of Residues	13
Details	RIBOSOMAL_S21 Ribosomal protein S21 signature. DvALRRFKRsceK

Chain	Residue	Details
u	ASP13-LYS25

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"HAMAP-Rule","id":"MF_01325","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	124
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Compositional bias: {"description":"Gly residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00501","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00251","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	68
Details	Domain: {"description":"KH type-2","evidences":[{"source":"HAMAP-Rule","id":"MF_01309","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	62
Details	Domain: {"description":"S4 RNA-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01306","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	63
Details	Domain: {"description":"S5 DRBM","evidences":[{"source":"HAMAP-Rule","id":"MF_01307","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"3-methylthioaspartic acid","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)