9SSS
Human Methionine Synthase With Methyltetrahydrofolate, Hydroxocobalamin, and SAM, C-Half His-ON From Full-Length
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0007399 | biological_process | nervous system development |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008705 | molecular_function | methionine synthase activity |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009235 | biological_process | cobalamin metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0031103 | biological_process | axon regeneration |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0032259 | biological_process | methylation |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048678 | biological_process | response to axon injury |
| A | 0050667 | biological_process | homocysteine metabolic process |
| A | 0071267 | biological_process | L-methionine salvage |
| A | 0071732 | biological_process | cellular response to nitric oxide |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 135 |
| Details | Domain: {"description":"B12-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00666","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 342 |
| Details | Domain: {"description":"AdoMet activation","evidences":[{"source":"PROSITE-ProRule","id":"PRU00346","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13009","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P13009","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9Z2Q4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
