9SPE
Human tRNA ligase complex bound by PYROXD1
Functional Information from PROSITE/UniProt
| site_id | PS01288 |
| Number of Residues | 30 |
| Details | UPF0027 Uncharacterized protein family UPF0027 signature. QIgNvAaLPgIvhrsigLPDvHsGyGfaIG |
| Chain | Residue | Details |
| R | GLN68-GLY97 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"C-terminal domain; interacts with and shields the RTCB catalytic center","evidences":[{"source":"PubMed","id":"40069351","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 13 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"40069351","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ORJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"GMP-histidine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ODO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8ODO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8ODP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ODO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ODP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8ODP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03144","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"38493148","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8BTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ODO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ODP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
