9SOS
Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002020 | molecular_function | protease binding |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005604 | cellular_component | basement membrane |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0007165 | biological_process | signal transduction |
| A | 0008083 | molecular_function | growth factor activity |
| A | 0008191 | molecular_function | metalloendopeptidase inhibitor activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009725 | biological_process | response to hormone |
| A | 0010951 | biological_process | negative regulation of endopeptidase activity |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0034097 | biological_process | response to cytokine |
| A | 0034774 | cellular_component | secretory granule lumen |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043086 | biological_process | negative regulation of catalytic activity |
| A | 0043434 | biological_process | response to peptide hormone |
| A | 0045861 | biological_process | negative regulation of proteolysis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051045 | biological_process | negative regulation of membrane protein ectodomain proteolysis |
| A | 0051216 | biological_process | cartilage development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071492 | biological_process | cellular response to UV-A |
| A | 1901164 | biological_process | negative regulation of trophoblast cell migration |
| A | 1901653 | biological_process | cellular response to peptide |
| A | 1905049 | biological_process | negative regulation of metallopeptidase activity |
| A | 1905641 | biological_process | cellular response to acetaldehyde |
| A | 2001044 | biological_process | regulation of integrin-mediated signaling pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00288 |
| Number of Residues | 13 |
| Details | TIMP Tissue inhibitors of metalloproteinases signature. CtCvPpHPQtaFC |
| Chain | Residue | Details |
| A | CYS1-CYS13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 123 |
| Details | Domain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000002","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000003","evidences":[{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
