9SOP

Tissue inhibitor of metalloproteinase-1 (TIMP-1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0004857	molecular_function	enzyme inhibitor activity
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005604	cellular_component	basement membrane
A	0005615	cellular_component	extracellular space
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0007165	biological_process	signal transduction
A	0008083	molecular_function	growth factor activity
A	0008191	molecular_function	metalloendopeptidase inhibitor activity
A	0008270	molecular_function	zinc ion binding
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009725	biological_process	response to hormone
A	0010951	biological_process	negative regulation of endopeptidase activity
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0031093	cellular_component	platelet alpha granule lumen
A	0034097	biological_process	response to cytokine
A	0034774	cellular_component	secretory granule lumen
A	0043066	biological_process	negative regulation of apoptotic process
A	0043086	biological_process	negative regulation of catalytic activity
A	0043434	biological_process	response to peptide hormone
A	0045861	biological_process	negative regulation of proteolysis
A	0046872	molecular_function	metal ion binding
A	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
A	0051216	biological_process	cartilage development
A	0070062	cellular_component	extracellular exosome
A	0071492	biological_process	cellular response to UV-A
A	1901164	biological_process	negative regulation of trophoblast cell migration
A	1901653	biological_process	cellular response to peptide
A	1905049	biological_process	negative regulation of metallopeptidase activity
A	1905641	biological_process	cellular response to acetaldehyde
A	2001044	biological_process	regulation of integrin-mediated signaling pathway
B	0002020	molecular_function	protease binding
B	0004857	molecular_function	enzyme inhibitor activity
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005604	cellular_component	basement membrane
B	0005615	cellular_component	extracellular space
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0007165	biological_process	signal transduction
B	0008083	molecular_function	growth factor activity
B	0008191	molecular_function	metalloendopeptidase inhibitor activity
B	0008270	molecular_function	zinc ion binding
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009725	biological_process	response to hormone
B	0010951	biological_process	negative regulation of endopeptidase activity
B	0030414	molecular_function	peptidase inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0031093	cellular_component	platelet alpha granule lumen
B	0034097	biological_process	response to cytokine
B	0034774	cellular_component	secretory granule lumen
B	0043066	biological_process	negative regulation of apoptotic process
B	0043086	biological_process	negative regulation of catalytic activity
B	0043434	biological_process	response to peptide hormone
B	0045861	biological_process	negative regulation of proteolysis
B	0046872	molecular_function	metal ion binding
B	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
B	0051216	biological_process	cartilage development
B	0070062	cellular_component	extracellular exosome
B	0071492	biological_process	cellular response to UV-A
B	1901164	biological_process	negative regulation of trophoblast cell migration
B	1901653	biological_process	cellular response to peptide
B	1905049	biological_process	negative regulation of metallopeptidase activity
B	1905641	biological_process	cellular response to acetaldehyde
B	2001044	biological_process	regulation of integrin-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00288
Number of Residues	13
Details	TIMP Tissue inhibitors of metalloproteinases signature. CtCvPpHPQtaFC

Chain	Residue	Details
A	CYS1-CYS13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Region: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"22427646","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3V96","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","featureId":"CAR_000002","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	123
Details	Domain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000003","evidences":[{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---