9SHP

Cryo-EM structure of the endogeneous MIWI in complex with pachytene piRNA at 3.3A

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003727	molecular_function	single-stranded RNA binding
B	0003729	molecular_function	mRNA binding
B	0004521	molecular_function	RNA endonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007283	biological_process	spermatogenesis
B	0007286	biological_process	spermatid development
B	0019901	molecular_function	protein kinase binding
B	0031047	biological_process	regulatory ncRNA-mediated gene silencing
B	0033391	cellular_component	chromatoid body
B	0034584	molecular_function	piRNA binding
B	0034587	biological_process	piRNA processing
B	0035092	biological_process	sperm DNA condensation
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0043186	cellular_component	P granule
B	0097433	cellular_component	dense body
B	0140262	molecular_function	mRNA cap binding complex binding
B	0140966	biological_process	piRNA-mediated heterochromatin formation
B	0140990	biological_process	primary piRNA processing
B	0140991	biological_process	piRNA-mediated gene silencing by mRNA destabilization
B	0141005	biological_process	transposable element silencing by heterochromatin formation
B	0141006	biological_process	transposable element silencing by piRNA-mediated heterochromatin formation
B	2000765	biological_process	regulation of cytoplasmic translation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Region: {"description":"Required for binding 2'-O-methylated 3'-end of piRNAs","evidences":[{"source":"PubMed","id":"21237665","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	136
Details	Region: {"description":"MID region","evidences":[{"source":"PubMed","id":"24757166","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	7
Details	Motif: {"description":"D-box","evidences":[{"source":"PubMed","id":"23328397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details