Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9S7G

SPACA9 and MNMIP1 bound to the seam of manchette microtubules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006457	biological_process	protein folding
A	0006458	biological_process	'de novo' protein folding
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008017	molecular_function	microtubule binding
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0019904	molecular_function	protein domain specific binding
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030317	biological_process	flagellated sperm motility
A	0030534	biological_process	adult behavior
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035371	cellular_component	microtubule plus-end
A	0035641	biological_process	locomotory exploration behavior
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0043209	cellular_component	myelin sheath
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0050821	biological_process	protein stabilization
A	0051087	molecular_function	protein-folding chaperone binding
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003725	molecular_function	double-stranded RNA binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005641	cellular_component	nuclear envelope lumen
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005879	cellular_component	axonemal microtubule
B	0005929	cellular_component	cilium
B	0005930	cellular_component	axoneme
B	0007017	biological_process	microtubule-based process
B	0007411	biological_process	axon guidance
B	0008150	biological_process	biological_process
B	0015630	cellular_component	microtubule cytoskeleton
B	0019904	molecular_function	protein domain specific binding
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030182	biological_process	neuron differentiation
B	0030317	biological_process	flagellated sperm motility
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0031115	biological_process	negative regulation of microtubule polymerization
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0032794	molecular_function	GTPase activating protein binding
B	0032991	cellular_component	protein-containing complex
B	0033269	cellular_component	internode region of axon
B	0036126	cellular_component	sperm flagellum
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0038007	biological_process	netrin-activated signaling pathway
B	0042277	molecular_function	peptide binding
B	0042288	molecular_function	MHC class I protein binding
B	0043025	cellular_component	neuronal cell body
B	0043209	cellular_component	myelin sheath
B	0044297	cellular_component	cell body
B	0044877	molecular_function	protein-containing complex binding
B	0045171	cellular_component	intercellular bridge
B	0050807	biological_process	regulation of synapse organization
B	0051225	biological_process	spindle assembly
B	0071895	biological_process	odontoblast differentiation
B	0071944	cellular_component	cell periphery
B	0072686	cellular_component	mitotic spindle
B	0097228	cellular_component	sperm principal piece
B	0097229	cellular_component	sperm end piece
B	0097542	cellular_component	ciliary tip
B	1990791	biological_process	dorsal root ganglion development
B	1990890	molecular_function	netrin receptor binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0000793	cellular_component	condensed chromosome
C	0001764	biological_process	neuron migration
C	0001964	biological_process	startle response
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005879	cellular_component	axonemal microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006457	biological_process	protein folding
C	0006458	biological_process	'de novo' protein folding
C	0006886	biological_process	intracellular protein transport
C	0007017	biological_process	microtubule-based process
C	0007098	biological_process	centrosome cycle
C	0007224	biological_process	smoothened signaling pathway
C	0007613	biological_process	memory
C	0007626	biological_process	locomotory behavior
C	0008017	molecular_function	microtubule binding
C	0008344	biological_process	adult locomotory behavior
C	0008542	biological_process	visual learning
C	0009612	biological_process	response to mechanical stimulus
C	0010001	biological_process	glial cell differentiation
C	0010467	biological_process	gene expression
C	0015630	cellular_component	microtubule cytoskeleton
C	0019904	molecular_function	protein domain specific binding
C	0021542	biological_process	dentate gyrus development
C	0021696	biological_process	cerebellar cortex morphogenesis
C	0021766	biological_process	hippocampus development
C	0021859	biological_process	pyramidal neuron differentiation
C	0021987	biological_process	cerebral cortex development
C	0022008	biological_process	neurogenesis
C	0030182	biological_process	neuron differentiation
C	0030317	biological_process	flagellated sperm motility
C	0030534	biological_process	adult behavior
C	0031594	cellular_component	neuromuscular junction
C	0034612	biological_process	response to tumor necrosis factor
C	0035371	cellular_component	microtubule plus-end
C	0035641	biological_process	locomotory exploration behavior
C	0036126	cellular_component	sperm flagellum
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042802	molecular_function	identical protein binding
C	0043209	cellular_component	myelin sheath
C	0044877	molecular_function	protein-containing complex binding
C	0045121	cellular_component	membrane raft
C	0045202	cellular_component	synapse
C	0046785	biological_process	microtubule polymerization
C	0046982	molecular_function	protein heterodimerization activity
C	0048853	biological_process	forebrain morphogenesis
C	0048873	biological_process	homeostasis of number of cells within a tissue
C	0050807	biological_process	regulation of synapse organization
C	0050808	biological_process	synapse organization
C	0050821	biological_process	protein stabilization
C	0051087	molecular_function	protein-folding chaperone binding
C	0051402	biological_process	neuron apoptotic process
C	0055037	cellular_component	recycling endosome
C	0061744	biological_process	motor behavior
C	0071277	biological_process	cellular response to calcium ion
C	0072384	biological_process	organelle transport along microtubule
C	0140058	biological_process	neuron projection arborization
C	1902065	biological_process	response to L-glutamate
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003725	molecular_function	double-stranded RNA binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005641	cellular_component	nuclear envelope lumen
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005879	cellular_component	axonemal microtubule
D	0005929	cellular_component	cilium
D	0005930	cellular_component	axoneme
D	0007017	biological_process	microtubule-based process
D	0007411	biological_process	axon guidance
D	0008150	biological_process	biological_process
D	0015630	cellular_component	microtubule cytoskeleton
D	0019904	molecular_function	protein domain specific binding
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030182	biological_process	neuron differentiation
D	0030317	biological_process	flagellated sperm motility
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0030426	cellular_component	growth cone
D	0031115	biological_process	negative regulation of microtubule polymerization
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032794	molecular_function	GTPase activating protein binding
D	0032991	cellular_component	protein-containing complex
D	0033269	cellular_component	internode region of axon
D	0036126	cellular_component	sperm flagellum
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0038007	biological_process	netrin-activated signaling pathway
D	0042277	molecular_function	peptide binding
D	0042288	molecular_function	MHC class I protein binding
D	0043025	cellular_component	neuronal cell body
D	0043209	cellular_component	myelin sheath
D	0044297	cellular_component	cell body
D	0044877	molecular_function	protein-containing complex binding
D	0045171	cellular_component	intercellular bridge
D	0050807	biological_process	regulation of synapse organization
D	0051225	biological_process	spindle assembly
D	0071895	biological_process	odontoblast differentiation
D	0071944	cellular_component	cell periphery
D	0072686	cellular_component	mitotic spindle
D	0097228	cellular_component	sperm principal piece
D	0097229	cellular_component	sperm end piece
D	0097542	cellular_component	ciliary tip
D	1990791	biological_process	dorsal root ganglion development
D	1990890	molecular_function	netrin receptor binding
E	0001669	cellular_component	acrosomal vesicle
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005879	cellular_component	axonemal microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005930	cellular_component	axoneme
E	0008017	molecular_function	microtubule binding
E	0030317	biological_process	flagellated sperm motility
E	0035082	biological_process	axoneme assembly
E	0036064	cellular_component	ciliary basal body
E	0036126	cellular_component	sperm flagellum
E	0048306	molecular_function	calcium-dependent protein binding
E	0097229	cellular_component	sperm end piece
E	0097546	cellular_component	ciliary base
E	0160110	cellular_component	axonemal microtubule doublet inner sheath

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Motif: {"description":"MREI motif","evidences":[{"source":"UniProtKB","id":"P07437","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"UniProtKB","id":"P68371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P68373","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Site: {"description":"Essential for interaction with INCA1","evidences":[{"source":"PubMed","id":"18756329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)