Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9S3T

Gephyrin dimer of dimers - combined CryoEM map

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0006605	biological_process	protein targeting
A	0006777	biological_process	Mo-molybdopterin cofactor biosynthetic process
A	0007416	biological_process	synapse assembly
A	0007529	biological_process	establishment of synaptic specificity at neuromuscular junction
A	0008940	molecular_function	nitrate reductase activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0010038	biological_process	response to metal ion
A	0014069	cellular_component	postsynaptic density
A	0015631	molecular_function	tubulin binding
A	0030425	cellular_component	dendrite
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0032324	biological_process	molybdopterin cofactor biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043197	cellular_component	dendritic spine
A	0043546	molecular_function	molybdopterin cofactor binding
A	0045184	biological_process	establishment of protein localization
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0050808	biological_process	synapse organization
A	0060077	cellular_component	inhibitory synapse
A	0060090	molecular_function	molecular adaptor activity
A	0061598	molecular_function	molybdopterin adenylyltransferase activity
A	0061599	molecular_function	molybdopterin molybdotransferase activity
A	0072579	biological_process	glycine receptor clustering
A	0097060	cellular_component	synaptic membrane
A	0097112	biological_process	gamma-aminobutyric acid receptor clustering
A	0098690	cellular_component	glycinergic synapse
A	0098794	cellular_component	postsynapse
A	0098982	cellular_component	GABA-ergic synapse
A	0099091	cellular_component	postsynaptic specialization, intracellular component
A	0099572	cellular_component	postsynaptic specialization
A	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0006605	biological_process	protein targeting
B	0006777	biological_process	Mo-molybdopterin cofactor biosynthetic process
B	0007416	biological_process	synapse assembly
B	0007529	biological_process	establishment of synaptic specificity at neuromuscular junction
B	0008940	molecular_function	nitrate reductase activity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010038	biological_process	response to metal ion
B	0014069	cellular_component	postsynaptic density
B	0015631	molecular_function	tubulin binding
B	0030425	cellular_component	dendrite
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0032324	biological_process	molybdopterin cofactor biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043197	cellular_component	dendritic spine
B	0043546	molecular_function	molybdopterin cofactor binding
B	0045184	biological_process	establishment of protein localization
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0050808	biological_process	synapse organization
B	0060077	cellular_component	inhibitory synapse
B	0060090	molecular_function	molecular adaptor activity
B	0061598	molecular_function	molybdopterin adenylyltransferase activity
B	0061599	molecular_function	molybdopterin molybdotransferase activity
B	0072579	biological_process	glycine receptor clustering
B	0097060	cellular_component	synaptic membrane
B	0097112	biological_process	gamma-aminobutyric acid receptor clustering
B	0098690	cellular_component	glycinergic synapse
B	0098794	cellular_component	postsynapse
B	0098982	cellular_component	GABA-ergic synapse
B	0099091	cellular_component	postsynaptic specialization, intracellular component
B	0099572	cellular_component	postsynaptic specialization
B	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0006605	biological_process	protein targeting
C	0006777	biological_process	Mo-molybdopterin cofactor biosynthetic process
C	0007416	biological_process	synapse assembly
C	0007529	biological_process	establishment of synaptic specificity at neuromuscular junction
C	0008940	molecular_function	nitrate reductase activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0010038	biological_process	response to metal ion
C	0014069	cellular_component	postsynaptic density
C	0015631	molecular_function	tubulin binding
C	0030425	cellular_component	dendrite
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0032324	biological_process	molybdopterin cofactor biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043197	cellular_component	dendritic spine
C	0043546	molecular_function	molybdopterin cofactor binding
C	0045184	biological_process	establishment of protein localization
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0050808	biological_process	synapse organization
C	0060077	cellular_component	inhibitory synapse
C	0060090	molecular_function	molecular adaptor activity
C	0061598	molecular_function	molybdopterin adenylyltransferase activity
C	0061599	molecular_function	molybdopterin molybdotransferase activity
C	0072579	biological_process	glycine receptor clustering
C	0097060	cellular_component	synaptic membrane
C	0097112	biological_process	gamma-aminobutyric acid receptor clustering
C	0098690	cellular_component	glycinergic synapse
C	0098794	cellular_component	postsynapse
C	0098982	cellular_component	GABA-ergic synapse
C	0099091	cellular_component	postsynaptic specialization, intracellular component
C	0099572	cellular_component	postsynaptic specialization
C	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
D	0005102	molecular_function	signaling receptor binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006605	biological_process	protein targeting
D	0006777	biological_process	Mo-molybdopterin cofactor biosynthetic process
D	0007416	biological_process	synapse assembly
D	0007529	biological_process	establishment of synaptic specificity at neuromuscular junction
D	0008940	molecular_function	nitrate reductase activity
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0010038	biological_process	response to metal ion
D	0014069	cellular_component	postsynaptic density
D	0015631	molecular_function	tubulin binding
D	0030425	cellular_component	dendrite
D	0030674	molecular_function	protein-macromolecule adaptor activity
D	0032324	biological_process	molybdopterin cofactor biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0043025	cellular_component	neuronal cell body
D	0043197	cellular_component	dendritic spine
D	0043546	molecular_function	molybdopterin cofactor binding
D	0045184	biological_process	establishment of protein localization
D	0045202	cellular_component	synapse
D	0045211	cellular_component	postsynaptic membrane
D	0050808	biological_process	synapse organization
D	0060077	cellular_component	inhibitory synapse
D	0060090	molecular_function	molecular adaptor activity
D	0061598	molecular_function	molybdopterin adenylyltransferase activity
D	0061599	molecular_function	molybdopterin molybdotransferase activity
D	0072579	biological_process	glycine receptor clustering
D	0097060	cellular_component	synaptic membrane
D	0097112	biological_process	gamma-aminobutyric acid receptor clustering
D	0098690	cellular_component	glycinergic synapse
D	0098794	cellular_component	postsynapse
D	0098982	cellular_component	GABA-ergic synapse
D	0099091	cellular_component	postsynaptic specialization, intracellular component
D	0099572	cellular_component	postsynaptic specialization
D	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane

Functional Information from PROSITE/UniProt

site_id	PS01078
Number of Residues	14
Details	MOCF_BIOSYNTHESIS_1 Molybdenum cofactor biosynthesis proteins signature 1. LILTTGGTGfaprD

Chain	Residue	Details
A	LEU81-ASP94

site_id	PS01079
Number of Residues	36
Details	MOCF_BIOSYNTHESIS_2 Molybdenum cofactor biosynthesis proteins signature 2. SmGekDylkqvLdidlhaqihfgrVfmKPGLPttFA

Chain	Residue	Details
A	SER575-ALA610

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27112598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ERR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ERT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ERU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ERV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27112598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ERS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27112598","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ERR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ERT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ERV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)