9S2M

Ternary structure of 14-3-3s, CRAF S257L NS mutant phosphopeptide (pS259), and compound 23 (1083848)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001836	biological_process	release of cytochrome c from mitochondria
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006469	biological_process	negative regulation of protein kinase activity
B	0007165	biological_process	signal transduction
B	0008104	biological_process	intracellular protein localization
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0010482	biological_process	regulation of epidermal cell division
B	0019901	molecular_function	protein kinase binding
B	0022407	biological_process	regulation of cell-cell adhesion
B	0030216	biological_process	keratinocyte differentiation
B	0030307	biological_process	positive regulation of cell growth
B	0032880	biological_process	regulation of protein localization
B	0035332	biological_process	positive regulation of hippo signaling
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045606	biological_process	positive regulation of epidermal cell differentiation
B	0045618	biological_process	positive regulation of keratinocyte differentiation
B	0045785	biological_process	positive regulation of cell adhesion
B	0045824	biological_process	negative regulation of innate immune response
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0050815	molecular_function	phosphoserine residue binding
B	0051219	molecular_function	phosphoprotein binding
B	0061436	biological_process	establishment of skin barrier
B	0070062	cellular_component	extracellular exosome
B	0140311	molecular_function	protein sequestering activity
B	1903077	biological_process	negative regulation of protein localization to plasma membrane
B	1903829	biological_process	positive regulation of protein localization
K	0001836	biological_process	release of cytochrome c from mitochondria
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006469	biological_process	negative regulation of protein kinase activity
K	0007165	biological_process	signal transduction
K	0008104	biological_process	intracellular protein localization
K	0008426	molecular_function	protein kinase C inhibitor activity
K	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
K	0010482	biological_process	regulation of epidermal cell division
K	0019901	molecular_function	protein kinase binding
K	0022407	biological_process	regulation of cell-cell adhesion
K	0030216	biological_process	keratinocyte differentiation
K	0030307	biological_process	positive regulation of cell growth
K	0032880	biological_process	regulation of protein localization
K	0035332	biological_process	positive regulation of hippo signaling
K	0042802	molecular_function	identical protein binding
K	0045296	molecular_function	cadherin binding
K	0045606	biological_process	positive regulation of epidermal cell differentiation
K	0045618	biological_process	positive regulation of keratinocyte differentiation
K	0045785	biological_process	positive regulation of cell adhesion
K	0045824	biological_process	negative regulation of innate immune response
K	0046827	biological_process	positive regulation of protein export from nucleus
K	0050815	molecular_function	phosphoserine residue binding
K	0051219	molecular_function	phosphoprotein binding
K	0061436	biological_process	establishment of skin barrier
K	0070062	cellular_component	extracellular exosome
K	0140311	molecular_function	protein sequestering activity
K	1903077	biological_process	negative regulation of protein localization to plasma membrane
K	1903829	biological_process	positive regulation of protein localization

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
B	ARG41-VAL51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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