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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9RX5

VPS34-CII (VPS34 199-REIE-202 to 199-AAAA-202 mutant) bound to RAB5A (Q79L)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000407cellular_componentphagophore assembly site
A0000425biological_processpexophagy
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005770cellular_componentlate endosome
A0005776cellular_componentautophagosome
A0005777cellular_componentperoxisome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0006622biological_processprotein targeting to lysosome
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0007032biological_processendosome organization
A0010506biological_processregulation of autophagy
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016241biological_processregulation of macroautophagy
A0016301molecular_functionkinase activity
A0016303molecular_function1-phosphatidylinositol-3-kinase activity
A0016485biological_processprotein processing
A0016773molecular_functionphosphotransferase activity, alcohol group as acceptor
A0030496cellular_componentmidbody
A0030670cellular_componentphagocytic vesicle membrane
A0032465biological_processregulation of cytokinesis
A0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
A0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
A0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
A0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
A0042149biological_processcellular response to glucose starvation
A0043201biological_processresponse to L-leucine
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0044754cellular_componentautolysosome
A0044829biological_processhost-mediated activation of viral genome replication
A0045022biological_processearly endosome to late endosome transport
A0045954biological_processpositive regulation of natural killer cell mediated cytotoxicity
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
A0048015biological_processphosphatidylinositol-mediated signaling
A0052742molecular_functionphosphatidylinositol kinase activity
A0097352biological_processautophagosome maturation
A1903061biological_processpositive regulation of protein lipidation
B0000425biological_processpexophagy
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005770cellular_componentlate endosome
B0005776cellular_componentautophagosome
B0005829cellular_componentcytosol
B0005930cellular_componentaxoneme
B0006468biological_processprotein phosphorylation
B0006622biological_processprotein targeting to lysosome
B0006623biological_processprotein targeting to vacuole
B0010506biological_processregulation of autophagy
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016241biological_processregulation of macroautophagy
B0030670cellular_componentphagocytic vesicle membrane
B0032465biological_processregulation of cytokinesis
B0032801biological_processreceptor catabolic process
B0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
B0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
B0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
B0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
B0042149biological_processcellular response to glucose starvation
B0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
B0045022biological_processearly endosome to late endosome transport
B0045324biological_processlate endosome to vacuole transport
B0071561cellular_componentnucleus-vacuole junction
B0097352biological_processautophagosome maturation
B0106310molecular_functionprotein serine kinase activity
C0000045biological_processautophagosome assembly
C0000407cellular_componentphagophore assembly site
C0000423biological_processmitophagy
C0001666biological_processresponse to hypoxia
C0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005768cellular_componentendosome
C0005776cellular_componentautophagosome
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005802cellular_componenttrans-Golgi network
C0005829cellular_componentcytosol
C0006622biological_processprotein targeting to lysosome
C0006914biological_processautophagy
C0006968biological_processcellular defense response
C0006995biological_processcellular response to nitrogen starvation
C0007080biological_processmitotic metaphase chromosome alignment
C0007254biological_processJNK cascade
C0007623biological_processcircadian rhythm
C0009410biological_processresponse to xenobiotic stimulus
C0010008cellular_componentendosome membrane
C0010040biological_processresponse to iron(II) ion
C0010288biological_processresponse to lead ion
C0010506biological_processregulation of autophagy
C0010508biological_processpositive regulation of autophagy
C0016236biological_processmacroautophagy
C0016241biological_processregulation of macroautophagy
C0016604cellular_componentnuclear body
C0019901molecular_functionprotein kinase binding
C0030425cellular_componentdendrite
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031625molecular_functionubiquitin protein ligase binding
C0031667biological_processresponse to nutrient levels
C0031966cellular_componentmitochondrial membrane
C0032465biological_processregulation of cytokinesis
C0032473cellular_componentcytoplasmic side of mitochondrial outer membrane
C0032801biological_processreceptor catabolic process
C0033197biological_processresponse to vitamin E
C0034198biological_processcellular response to amino acid starvation
C0034271cellular_componentphosphatidylinositol 3-kinase complex, class III, type I
C0034272cellular_componentphosphatidylinositol 3-kinase complex, class III, type II
C0035032cellular_componentphosphatidylinositol 3-kinase complex, class III
C0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
C0038066biological_processp38MAPK cascade
C0042149biological_processcellular response to glucose starvation
C0043066biological_processnegative regulation of apoptotic process
C0043069biological_processnegative regulation of programmed cell death
C0043548molecular_functionphosphatidylinositol 3-kinase binding
C0043652biological_processengulfment of apoptotic cell
C0045022biological_processearly endosome to late endosome transport
C0045324biological_processlate endosome to vacuole transport
C0051020molecular_functionGTPase binding
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0060090molecular_functionmolecular adaptor activity
C0060395biological_processSMAD protein signal transduction
C0062029biological_processpositive regulation of stress granule assembly
C0065003biological_processprotein-containing complex assembly
C0070301biological_processcellular response to hydrogen peroxide
C0071275biological_processcellular response to aluminum ion
C0071280biological_processcellular response to copper ion
C0071364biological_processcellular response to epidermal growth factor stimulus
C0090650biological_processcellular response to oxygen-glucose deprivation
C0097352biological_processautophagosome maturation
C0098780biological_processresponse to mitochondrial depolarisation
C1902425biological_processpositive regulation of attachment of mitotic spindle microtubules to kinetochore
C1905672biological_processnegative regulation of lysosome organization
C2000786biological_processpositive regulation of autophagosome assembly
C2001244biological_processpositive regulation of intrinsic apoptotic signaling pathway
D0000775cellular_componentchromosome, centromeric region
D0005764cellular_componentlysosome
D0005769cellular_componentearly endosome
D0005770cellular_componentlate endosome
D0005776cellular_componentautophagosome
D0005783cellular_componentendoplasmic reticulum
D0006281biological_processDNA repair
D0006914biological_processautophagy
D0007098biological_processcentrosome cycle
D0016192biological_processvesicle-mediated transport
D0030496cellular_componentmidbody
D0031410cellular_componentcytoplasmic vesicle
D0036092biological_processphosphatidylinositol-3-phosphate biosynthetic process
D0043933biological_processprotein-containing complex organization
E0001726cellular_componentruffle
E0003924molecular_functionGTPase activity
E0003925molecular_functionG protein activity
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005737cellular_componentcytoplasm
E0005768cellular_componentendosome
E0005769cellular_componentearly endosome
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006886biological_processintracellular protein transport
E0006897biological_processendocytosis
E0008021cellular_componentsynaptic vesicle
E0010008cellular_componentendosome membrane
E0012505cellular_componentendomembrane system
E0016020cellular_componentmembrane
E0016197biological_processendosomal transport
E0019003molecular_functionGDP binding
E0030139cellular_componentendocytic vesicle
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0030669cellular_componentclathrin-coated endocytic vesicle membrane
E0030670cellular_componentphagocytic vesicle membrane
E0030672cellular_componentsynaptic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0031623biological_processreceptor internalization
E0031901cellular_componentearly endosome membrane
E0032009cellular_componentearly phagosome
E0036465biological_processsynaptic vesicle recycling
E0036477cellular_componentsomatodendritic compartment
E0042470cellular_componentmelanosome
E0043025cellular_componentneuronal cell body
E0043195cellular_componentterminal bouton
E0043679cellular_componentaxon terminus
E0044788biological_processhost-mediated perturbation of viral process
E0045022biological_processearly endosome to late endosome transport
E0045335cellular_componentphagocytic vesicle
E0045921biological_processpositive regulation of exocytosis
E0048169biological_processregulation of long-term neuronal synaptic plasticity
E0048227biological_processplasma membrane to endosome transport
E0051036biological_processregulation of endosome size
E0051489biological_processregulation of filopodium assembly
E0060070biological_processcanonical Wnt signaling pathway
E0061025biological_processmembrane fusion
E0070062cellular_componentextracellular exosome
E0098559cellular_componentcytoplasmic side of early endosome membrane
E0150093biological_processamyloid-beta clearance by transcytosis
E1902946biological_processprotein localization to early endosome
E2000300biological_processregulation of synaptic vesicle exocytosis
E2000785biological_processregulation of autophagosome assembly
F0001726cellular_componentruffle
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005768cellular_componentendosome
F0005769cellular_componentearly endosome
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006886biological_processintracellular protein transport
F0006897biological_processendocytosis
F0008021cellular_componentsynaptic vesicle
F0010008cellular_componentendosome membrane
F0012505cellular_componentendomembrane system
F0016020cellular_componentmembrane
F0016197biological_processendosomal transport
F0019003molecular_functionGDP binding
F0030139cellular_componentendocytic vesicle
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0030669cellular_componentclathrin-coated endocytic vesicle membrane
F0030670cellular_componentphagocytic vesicle membrane
F0030672cellular_componentsynaptic vesicle membrane
F0031410cellular_componentcytoplasmic vesicle
F0031623biological_processreceptor internalization
F0031901cellular_componentearly endosome membrane
F0032009cellular_componentearly phagosome
F0036465biological_processsynaptic vesicle recycling
F0036477cellular_componentsomatodendritic compartment
F0042470cellular_componentmelanosome
F0043025cellular_componentneuronal cell body
F0043195cellular_componentterminal bouton
F0043679cellular_componentaxon terminus
F0044788biological_processhost-mediated perturbation of viral process
F0045022biological_processearly endosome to late endosome transport
F0045335cellular_componentphagocytic vesicle
F0045921biological_processpositive regulation of exocytosis
F0048169biological_processregulation of long-term neuronal synaptic plasticity
F0048227biological_processplasma membrane to endosome transport
F0051036biological_processregulation of endosome size
F0051489biological_processregulation of filopodium assembly
F0060070biological_processcanonical Wnt signaling pathway
F0061025biological_processmembrane fusion
F0070062cellular_componentextracellular exosome
F0098559cellular_componentcytoplasmic side of early endosome membrane
F0150093biological_processamyloid-beta clearance by transcytosis
F1902946biological_processprotein localization to early endosome
F2000300biological_processregulation of synaptic vesicle exocytosis
F2000785biological_processregulation of autophagosome assembly
Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ
ChainResidueDetails
APHE635-GLN649
site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN
ChainResidueDetails
ASER728-ASN748
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues266
DetailsDomain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues21
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q6PF93","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O88763","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues37
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues37
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues38
DetailsRepeat: {"description":"HEAT 3"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues39
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues39
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues41
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues39
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues41
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues41
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues31
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsLipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999962","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues47
DetailsRegion: {"description":"Interaction with BCL2 and BCL2L1 isoform Bcl-X(L)","evidences":[{"source":"PubMed","id":"17446862","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues205
DetailsRegion: {"description":"Evolutionary conserved domain (ECD)","evidences":[{"source":"PubMed","id":"28445460","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues25
DetailsRegion: {"description":"Required for membrane-association","evidences":[{"source":"PubMed","id":"23878393","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues128
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"31123703","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by DAPK1","evidences":[{"source":"PubMed","id":"19180116","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28445460","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23974797","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues16
DetailsRegion: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues32
DetailsRegion: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00753","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"12433916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14684892","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15378032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1N6H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N6R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MJH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P62820","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by LRRK2","evidences":[{"source":"PubMed","id":"29125462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues2
DetailsGlycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"32974215","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2026-07-22

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