9RVA
Crystal structure of the extracellular part of human ACE2 in complex with the macrocyclic peptide WJL-63
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0001817 | biological_process | regulation of cytokine production |
| A | 0002003 | biological_process | angiotensin maturation |
| A | 0003051 | biological_process | angiotensin-mediated drinking behavior |
| A | 0003081 | biological_process | regulation of systemic arterial blood pressure by renin-angiotensin |
| A | 0004175 | molecular_function | endopeptidase activity |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0004181 | molecular_function | metallocarboxypeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005929 | cellular_component | cilium |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008241 | molecular_function | peptidyl-dipeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009986 | cellular_component | cell surface |
| A | 0015827 | biological_process | tryptophan transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0019058 | biological_process | viral life cycle |
| A | 0019065 | biological_process | receptor-mediated endocytosis of virus by host cell |
| A | 0019229 | biological_process | regulation of vasoconstriction |
| A | 0030666 | cellular_component | endocytic vesicle membrane |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045121 | cellular_component | membrane raft |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0048662 | biological_process | negative regulation of smooth muscle cell proliferation |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051957 | biological_process | positive regulation of amino acid transport |
| A | 0060135 | biological_process | maternal process involved in female pregnancy |
| A | 0060452 | biological_process | positive regulation of cardiac muscle contraction |
| A | 0061025 | biological_process | membrane fusion |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
| A | 0089718 | biological_process | amino acid import across plasma membrane |
| A | 0097746 | biological_process | blood vessel diameter maintenance |
| A | 0098670 | biological_process | entry receptor-mediated virion attachment to host cell |
| A | 0141109 | molecular_function | transporter activator activity |
| A | 1902495 | cellular_component | transmembrane transporter complex |
| A | 1903598 | biological_process | positive regulation of gap junction assembly |
| A | 1903779 | biological_process | regulation of cardiac conduction |
| A | 1905737 | biological_process | positive regulation of L-proline import across plasma membrane |
| A | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TAHHEMGHIQ |
| Chain | Residue | Details |
| A | THR371-GLN380 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 588 |
| Details | Domain: {"description":"Peptidase M2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | Region: {"description":"Interaction with SARS-CoV spike glycoprotein","evidences":[{"source":"PubMed","id":"15791205","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Region: {"description":"Essential for cleavage by ADAM17","evidences":[{"source":"PubMed","id":"24227843","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27217402","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19021774","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01355","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14754895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19901337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
