9RUP

Cryo-EM structure of TCRpub/pMHC dimer

Functional Information from GO Data

Chain	GOid	namespace	contents
e	0000139	cellular_component	Golgi membrane
e	0002376	biological_process	immune system process
e	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
e	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
e	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
e	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
e	0002715	biological_process	regulation of natural killer cell mediated immunity
e	0002726	biological_process	positive regulation of T cell cytokine production
e	0005198	molecular_function	structural molecule activity
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005615	cellular_component	extracellular space
e	0005765	cellular_component	lysosomal membrane
e	0005783	cellular_component	endoplasmic reticulum
e	0005788	cellular_component	endoplasmic reticulum lumen
e	0005794	cellular_component	Golgi apparatus
e	0005886	cellular_component	plasma membrane
e	0005925	cellular_component	focal adhesion
e	0006879	biological_process	intracellular iron ion homeostasis
e	0007608	biological_process	sensory perception of smell
e	0007611	biological_process	learning or memory
e	0009897	cellular_component	external side of plasma membrane
e	0009986	cellular_component	cell surface
e	0010038	biological_process	response to metal ion
e	0012507	cellular_component	ER to Golgi transport vesicle membrane
e	0016020	cellular_component	membrane
e	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
e	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
e	0023026	molecular_function	MHC class II protein complex binding
e	0030670	cellular_component	phagocytic vesicle membrane
e	0031901	cellular_component	early endosome membrane
e	0031902	cellular_component	late endosome membrane
e	0031905	cellular_component	early endosome lumen
e	0033572	biological_process	transferrin transport
e	0034756	biological_process	regulation of iron ion transport
e	0034757	biological_process	negative regulation of iron ion transport
e	0035580	cellular_component	specific granule lumen
e	0042605	molecular_function	peptide antigen binding
e	0042612	cellular_component	MHC class I protein complex
e	0042613	cellular_component	MHC class II protein complex
e	0042802	molecular_function	identical protein binding
e	0042803	molecular_function	protein homodimerization activity
e	0042824	cellular_component	MHC class I peptide loading complex
e	0048260	biological_process	positive regulation of receptor-mediated endocytosis
e	0048261	biological_process	negative regulation of receptor-mediated endocytosis
e	0050680	biological_process	negative regulation of epithelial cell proliferation
e	0050768	biological_process	negative regulation of neurogenesis
e	0050778	biological_process	positive regulation of immune response
e	0050870	biological_process	positive regulation of T cell activation
e	0051289	biological_process	protein homotetramerization
e	0055038	cellular_component	recycling endosome membrane
e	0070062	cellular_component	extracellular exosome
e	0071281	biological_process	cellular response to iron ion
e	0071316	biological_process	cellular response to nicotine
e	1904724	cellular_component	tertiary granule lumen
e	1990000	biological_process	amyloid fibril formation
e	1990712	cellular_component	HFE-transferrin receptor complex
e	2000774	biological_process	positive regulation of cellular senescence
e	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0000139	cellular_component	Golgi membrane
E	0002376	biological_process	immune system process
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002477	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class Ib
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002715	biological_process	regulation of natural killer cell mediated immunity
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006879	biological_process	intracellular iron ion homeostasis
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010038	biological_process	response to metal ion
E	0012507	cellular_component	ER to Golgi transport vesicle membrane
E	0016020	cellular_component	membrane
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031901	cellular_component	early endosome membrane
E	0031902	cellular_component	late endosome membrane
E	0031905	cellular_component	early endosome lumen
E	0033572	biological_process	transferrin transport
E	0034756	biological_process	regulation of iron ion transport
E	0034757	biological_process	negative regulation of iron ion transport
E	0035580	cellular_component	specific granule lumen
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0048261	biological_process	negative regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0055038	cellular_component	recycling endosome membrane
E	0070062	cellular_component	extracellular exosome
E	0071281	biological_process	cellular response to iron ion
E	0071316	biological_process	cellular response to nicotine
E	1904724	cellular_component	tertiary granule lumen
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
C	TYR255-HIS261
E	TYR78-HIS84

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Domain: {"description":"Ig-like C1-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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