9RUF

Cryo-EM structure of the LB_DQB0301_A Fab - HLA-DQB1*03:01/DQA1*05:02 human alloantibody-HLA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
A	0005515	molecular_function	protein binding
A	0005765	cellular_component	lysosomal membrane
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0010008	cellular_component	endosome membrane
A	0012507	cellular_component	ER to Golgi transport vesicle membrane
A	0016020	cellular_component	membrane
A	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
A	0023026	molecular_function	MHC class II protein complex binding
A	0030658	cellular_component	transport vesicle membrane
A	0030666	cellular_component	endocytic vesicle membrane
A	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
A	0031902	cellular_component	late endosome membrane
A	0032395	molecular_function	MHC class II receptor activity
A	0032588	cellular_component	trans-Golgi network membrane
A	0042605	molecular_function	peptide antigen binding
A	0042613	cellular_component	MHC class II protein complex
A	0050778	biological_process	positive regulation of immune response
A	0050870	biological_process	positive regulation of T cell activation
A	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
B	0000139	cellular_component	Golgi membrane
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0005515	molecular_function	protein binding
B	0005765	cellular_component	lysosomal membrane
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006955	biological_process	immune response
B	0006959	biological_process	humoral immune response
B	0010008	cellular_component	endosome membrane
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030658	cellular_component	transport vesicle membrane
B	0030666	cellular_component	endocytic vesicle membrane
B	0030669	cellular_component	clathrin-coated endocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0032395	molecular_function	MHC class II receptor activity
B	0032588	cellular_component	trans-Golgi network membrane
B	0042605	molecular_function	peptide antigen binding
B	0042613	cellular_component	MHC class II protein complex
B	0050778	biological_process	positive regulation of immune response
B	0050852	biological_process	T cell receptor signaling pathway
B	0050870	biological_process	positive regulation of T cell activation
B	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCKVEH

Chain	Residue	Details
A	TYR163-HIS169
B	TYR171-HIS177
H	TYR200-HIS206
L	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	92
Details	Domain: {"description":"Ig-like C1-type"}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	83
Details	Region: {"description":"Alpha-2"}

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Residue

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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