9RMS

GluA4 in complex with TARP-2, Resting II state, structure of TMD/LBD domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004970	molecular_function	glutamate-gated receptor activity
A	0004971	molecular_function	AMPA glutamate receptor activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0007268	biological_process	chemical synaptic transmission
A	0008328	cellular_component	ionotropic glutamate receptor complex
A	0014069	cellular_component	postsynaptic density
A	0023051	biological_process	regulation of signaling
A	0030425	cellular_component	dendrite
A	0032281	cellular_component	AMPA glutamate receptor complex
A	0032983	cellular_component	kainate selective glutamate receptor complex
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034392	biological_process	negative regulation of smooth muscle cell apoptotic process
A	0035235	biological_process	ionotropic glutamate receptor signaling pathway
A	0035249	biological_process	synaptic transmission, glutamatergic
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043195	cellular_component	terminal bouton
A	0043197	cellular_component	dendritic spine
A	0045202	cellular_component	synapse
A	0045211	cellular_component	postsynaptic membrane
A	0048787	cellular_component	presynaptic active zone membrane
A	0050803	biological_process	regulation of synapse structure or activity
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
A	0060078	biological_process	regulation of postsynaptic membrane potential
A	0060992	biological_process	response to fungicide
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B	0004970	molecular_function	glutamate-gated receptor activity
B	0004971	molecular_function	AMPA glutamate receptor activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0007268	biological_process	chemical synaptic transmission
B	0008328	cellular_component	ionotropic glutamate receptor complex
B	0014069	cellular_component	postsynaptic density
B	0023051	biological_process	regulation of signaling
B	0030425	cellular_component	dendrite
B	0032281	cellular_component	AMPA glutamate receptor complex
B	0032983	cellular_component	kainate selective glutamate receptor complex
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034392	biological_process	negative regulation of smooth muscle cell apoptotic process
B	0035235	biological_process	ionotropic glutamate receptor signaling pathway
B	0035249	biological_process	synaptic transmission, glutamatergic
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043195	cellular_component	terminal bouton
B	0043197	cellular_component	dendritic spine
B	0045202	cellular_component	synapse
B	0045211	cellular_component	postsynaptic membrane
B	0048787	cellular_component	presynaptic active zone membrane
B	0050803	biological_process	regulation of synapse structure or activity
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060992	biological_process	response to fungicide
B	0098839	cellular_component	postsynaptic density membrane
B	0098978	cellular_component	glutamatergic synapse
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	0004970	molecular_function	glutamate-gated receptor activity
C	0004971	molecular_function	AMPA glutamate receptor activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0007268	biological_process	chemical synaptic transmission
C	0008328	cellular_component	ionotropic glutamate receptor complex
C	0014069	cellular_component	postsynaptic density
C	0023051	biological_process	regulation of signaling
C	0030425	cellular_component	dendrite
C	0032281	cellular_component	AMPA glutamate receptor complex
C	0032983	cellular_component	kainate selective glutamate receptor complex
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034392	biological_process	negative regulation of smooth muscle cell apoptotic process
C	0035235	biological_process	ionotropic glutamate receptor signaling pathway
C	0035249	biological_process	synaptic transmission, glutamatergic
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043195	cellular_component	terminal bouton
C	0043197	cellular_component	dendritic spine
C	0045202	cellular_component	synapse
C	0045211	cellular_component	postsynaptic membrane
C	0048787	cellular_component	presynaptic active zone membrane
C	0050803	biological_process	regulation of synapse structure or activity
C	0050804	biological_process	modulation of chemical synaptic transmission
C	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060992	biological_process	response to fungicide
C	0098839	cellular_component	postsynaptic density membrane
C	0098978	cellular_component	glutamatergic synapse
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D	0004970	molecular_function	glutamate-gated receptor activity
D	0004971	molecular_function	AMPA glutamate receptor activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0007268	biological_process	chemical synaptic transmission
D	0008328	cellular_component	ionotropic glutamate receptor complex
D	0014069	cellular_component	postsynaptic density
D	0023051	biological_process	regulation of signaling
D	0030425	cellular_component	dendrite
D	0032281	cellular_component	AMPA glutamate receptor complex
D	0032983	cellular_component	kainate selective glutamate receptor complex
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034392	biological_process	negative regulation of smooth muscle cell apoptotic process
D	0035235	biological_process	ionotropic glutamate receptor signaling pathway
D	0035249	biological_process	synaptic transmission, glutamatergic
D	0042802	molecular_function	identical protein binding
D	0043025	cellular_component	neuronal cell body
D	0043195	cellular_component	terminal bouton
D	0043197	cellular_component	dendritic spine
D	0045202	cellular_component	synapse
D	0045211	cellular_component	postsynaptic membrane
D	0048787	cellular_component	presynaptic active zone membrane
D	0050803	biological_process	regulation of synapse structure or activity
D	0050804	biological_process	modulation of chemical synaptic transmission
D	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
D	0060078	biological_process	regulation of postsynaptic membrane potential
D	0060992	biological_process	response to fungicide
D	0098839	cellular_component	postsynaptic density membrane
D	0098978	cellular_component	glutamatergic synapse
D	0099505	biological_process	regulation of presynaptic membrane potential
D	0099507	molecular_function	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E	0005245	molecular_function	voltage-gated calcium channel activity
E	0005246	molecular_function	calcium channel regulator activity
E	0005262	molecular_function	calcium channel activity
E	0005515	molecular_function	protein binding
E	0006612	biological_process	protein targeting to membrane
E	0006811	biological_process	monoatomic ion transport
E	0006816	biological_process	calcium ion transport
E	0007528	biological_process	neuromuscular junction development
E	0009986	cellular_component	cell surface
E	0016020	cellular_component	membrane
E	0016247	molecular_function	channel regulator activity
E	0019226	biological_process	transmission of nerve impulse
E	0032281	cellular_component	AMPA glutamate receptor complex
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0035255	molecular_function	ionotropic glutamate receptor binding
E	0036477	cellular_component	somatodendritic compartment
E	0042391	biological_process	regulation of membrane potential
E	0043005	cellular_component	neuron projection
E	0044300	cellular_component	cerebellar mossy fiber
E	0045202	cellular_component	synapse
E	0050877	biological_process	nervous system process
E	0051592	biological_process	response to calcium ion
E	0051899	biological_process	membrane depolarization
E	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
E	0060081	biological_process	membrane hyperpolarization
E	0060082	biological_process	eye blink reflex
E	0070588	biological_process	calcium ion transmembrane transport
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
E	0098839	cellular_component	postsynaptic density membrane
E	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
E	0098978	cellular_component	glutamatergic synapse
E	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
E	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
E	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
E	2000311	biological_process	regulation of AMPA receptor activity
E	2000969	biological_process	positive regulation of AMPA receptor activity
F	0005245	molecular_function	voltage-gated calcium channel activity
F	0005246	molecular_function	calcium channel regulator activity
F	0005262	molecular_function	calcium channel activity
F	0005515	molecular_function	protein binding
F	0006612	biological_process	protein targeting to membrane
F	0006811	biological_process	monoatomic ion transport
F	0006816	biological_process	calcium ion transport
F	0007528	biological_process	neuromuscular junction development
F	0009986	cellular_component	cell surface
F	0016020	cellular_component	membrane
F	0016247	molecular_function	channel regulator activity
F	0019226	biological_process	transmission of nerve impulse
F	0032281	cellular_component	AMPA glutamate receptor complex
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0035255	molecular_function	ionotropic glutamate receptor binding
F	0036477	cellular_component	somatodendritic compartment
F	0042391	biological_process	regulation of membrane potential
F	0043005	cellular_component	neuron projection
F	0044300	cellular_component	cerebellar mossy fiber
F	0045202	cellular_component	synapse
F	0050877	biological_process	nervous system process
F	0051592	biological_process	response to calcium ion
F	0051899	biological_process	membrane depolarization
F	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
F	0060081	biological_process	membrane hyperpolarization
F	0060082	biological_process	eye blink reflex
F	0070588	biological_process	calcium ion transmembrane transport
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
F	0098839	cellular_component	postsynaptic density membrane
F	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
F	0098978	cellular_component	glutamatergic synapse
F	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
F	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
F	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
F	2000311	biological_process	regulation of AMPA receptor activity
F	2000969	biological_process	positive regulation of AMPA receptor activity
G	0005245	molecular_function	voltage-gated calcium channel activity
G	0005246	molecular_function	calcium channel regulator activity
G	0005262	molecular_function	calcium channel activity
G	0005515	molecular_function	protein binding
G	0006612	biological_process	protein targeting to membrane
G	0006811	biological_process	monoatomic ion transport
G	0006816	biological_process	calcium ion transport
G	0007528	biological_process	neuromuscular junction development
G	0009986	cellular_component	cell surface
G	0016020	cellular_component	membrane
G	0016247	molecular_function	channel regulator activity
G	0019226	biological_process	transmission of nerve impulse
G	0032281	cellular_component	AMPA glutamate receptor complex
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0035255	molecular_function	ionotropic glutamate receptor binding
G	0036477	cellular_component	somatodendritic compartment
G	0042391	biological_process	regulation of membrane potential
G	0043005	cellular_component	neuron projection
G	0044300	cellular_component	cerebellar mossy fiber
G	0045202	cellular_component	synapse
G	0050877	biological_process	nervous system process
G	0051592	biological_process	response to calcium ion
G	0051899	biological_process	membrane depolarization
G	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
G	0060081	biological_process	membrane hyperpolarization
G	0060082	biological_process	eye blink reflex
G	0070588	biological_process	calcium ion transmembrane transport
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
G	0098839	cellular_component	postsynaptic density membrane
G	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
G	0098978	cellular_component	glutamatergic synapse
G	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
G	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
G	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
G	2000311	biological_process	regulation of AMPA receptor activity
G	2000969	biological_process	positive regulation of AMPA receptor activity
H	0005245	molecular_function	voltage-gated calcium channel activity
H	0005246	molecular_function	calcium channel regulator activity
H	0005262	molecular_function	calcium channel activity
H	0005515	molecular_function	protein binding
H	0006612	biological_process	protein targeting to membrane
H	0006811	biological_process	monoatomic ion transport
H	0006816	biological_process	calcium ion transport
H	0007528	biological_process	neuromuscular junction development
H	0009986	cellular_component	cell surface
H	0016020	cellular_component	membrane
H	0016247	molecular_function	channel regulator activity
H	0019226	biological_process	transmission of nerve impulse
H	0032281	cellular_component	AMPA glutamate receptor complex
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0034702	cellular_component	monoatomic ion channel complex
H	0035255	molecular_function	ionotropic glutamate receptor binding
H	0036477	cellular_component	somatodendritic compartment
H	0042391	biological_process	regulation of membrane potential
H	0043005	cellular_component	neuron projection
H	0044300	cellular_component	cerebellar mossy fiber
H	0045202	cellular_component	synapse
H	0050877	biological_process	nervous system process
H	0051592	biological_process	response to calcium ion
H	0051899	biological_process	membrane depolarization
H	0051968	biological_process	positive regulation of synaptic transmission, glutamatergic
H	0060081	biological_process	membrane hyperpolarization
H	0060082	biological_process	eye blink reflex
H	0070588	biological_process	calcium ion transmembrane transport
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
H	0098839	cellular_component	postsynaptic density membrane
H	0098970	biological_process	postsynaptic neurotransmitter receptor diffusion trapping
H	0098978	cellular_component	glutamatergic synapse
H	0099072	biological_process	regulation of postsynaptic membrane neurotransmitter receptor levels
H	0099645	biological_process	neurotransmitter receptor localization to postsynaptic specialization membrane
H	1904510	biological_process	positive regulation of protein localization to basolateral plasma membrane
H	2000311	biological_process	regulation of AMPA receptor activity
H	2000969	biological_process	positive regulation of AMPA receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	160
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	Intramembrane: {"description":"Helical; Pore-forming","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Intramembrane: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=M4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19022251","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19102704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20107073","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EPE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KEI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P42262","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	320
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---