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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9RHA

Cryo-EM structure of the inward-facing apo NhaA with flexible N-terminus at pH 5.5

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues54
DetailsTopological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues85
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues7
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues21
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues19
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues17
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues18
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues23
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues10
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues7
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ATV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4AU5","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues13
DetailsRegion: {"description":"Important for dimerization","evidences":[{"source":"PubMed","id":"17635927","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23836890","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"Important for stability, cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29410365","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsSite: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsSite: {"description":"Essential for cation binding and translocation","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19274728","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27021484","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"7737413","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsSite: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"10455127","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsSite: {"description":"Important for pH response","evidences":[{"source":"PubMed","id":"14604993","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsSite: {"description":"Important for stability and activity","evidences":[{"source":"PubMed","id":"15988517","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22915592","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25422503","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27708266","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28330875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30409911","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

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PDB entries from 2026-06-17

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