9RGS

Crystal Structure of Rattus norvegicus Enoyl-CoA Hydratase in complex with 3S-hydroxyhexanoyl-CoA

Functional Information from PROSITE/UniProt

site_id	PS00166
Number of Residues	21
Details	ENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. IAaVNGyalGGGcelaMmCDI

Chain	Residue	Details
A	ILE131-ILE151
B	ILE131-ILE151

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Important for catalytic activity"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q8BH95","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BH95","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8BH95","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 315

Chain	Residue	Details
B	ALA98	activator, electrostatic stabiliser
B	GLY141	activator, electrostatic stabiliser
B	GLU144	hydrogen bond acceptor, increase basicity
B	GLU164	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 315

Chain	Residue	Details
C	ALA98	activator, electrostatic stabiliser
C	GLY141	activator, electrostatic stabiliser
C	GLU144	hydrogen bond acceptor, increase basicity
C	GLU164	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA3
Number of Residues	4
Details	M-CSA 315

Chain	Residue	Details
E	GLU102	activator, electrostatic stabiliser
E	LEU145	activator, electrostatic stabiliser
E	MET148	hydrogen bond acceptor, increase basicity
E	GLY168	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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site_id	MCSA4
Number of Residues	4
Details	M-CSA 315

Chain	Residue	Details
F	GLU102	activator, electrostatic stabiliser
F	LEU145	activator, electrostatic stabiliser
F	MET148	hydrogen bond acceptor, increase basicity
F	GLY168	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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