9RBW

Cryo-EM structure of ANP amyloids from left atrial appendage of atrial fibrillation patient - polymorph B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
M	0005179	molecular_function	hormone activity
M	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region
P	0005179	molecular_function	hormone activity
P	0005576	cellular_component	extracellular region
Q	0005179	molecular_function	hormone activity
Q	0005576	cellular_component	extracellular region
R	0005179	molecular_function	hormone activity
R	0005576	cellular_component	extracellular region
S	0005179	molecular_function	hormone activity
S	0005576	cellular_component	extracellular region
T	0005179	molecular_function	hormone activity
T	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00263
Number of Residues	17
Details	NATRIURETIC_PEPTIDE Natriuretic peptides signature. CFGgrmDRIgaqSglGC

Chain	Residue	Details
C	CYS7-CYS23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Peptide: {"description":"Auriculin-B","featureId":"PRO_0000449730","evidences":[{"source":"UniProtKB","id":"P01161","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	460
Details	Peptide: {"description":"Auriculin-A","featureId":"PRO_0000449731","evidences":[{"source":"UniProtKB","id":"P01161","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	460
Details	Peptide: {"description":"Atriopeptin-3","featureId":"PRO_0000449732","evidences":[{"source":"UniProtKB","id":"P01161","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	440
Details	Peptide: {"description":"Atriopeptin-2","featureId":"PRO_0000449733","evidences":[{"source":"UniProtKB","id":"P01161","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	400
Details	Peptide: {"description":"Atriopeptin-1","featureId":"PRO_0000449734","evidences":[{"source":"UniProtKB","id":"P01161","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	Region: {"description":"Important for degradation of atrial natriuretic peptide by IDE","evidences":[{"source":"PubMed","id":"21098034","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Site: {"description":"Cleavage; by MME","evidences":[{"source":"PubMed","id":"2972276","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"2528951","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---