9R6Z

Cubic state of the F420-reducing hydrogenase from Methanothermococcus thermolithotrophicus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008901	molecular_function	ferredoxin hydrogenase activity
A	0016151	molecular_function	nickel cation binding
A	0050454	molecular_function	coenzyme F420 hydrogenase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0051536	molecular_function	iron-sulfur cluster binding
B	0016151	molecular_function	nickel cation binding
B	0016491	molecular_function	oxidoreductase activity
B	0050454	molecular_function	coenzyme F420 hydrogenase activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
C	0016151	molecular_function	nickel cation binding
C	0050454	molecular_function	coenzyme F420 hydrogenase activity
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0051536	molecular_function	iron-sulfur cluster binding
D	0008901	molecular_function	ferredoxin hydrogenase activity
D	0016151	molecular_function	nickel cation binding
D	0050454	molecular_function	coenzyme F420 hydrogenase activity
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0051536	molecular_function	iron-sulfur cluster binding
E	0016151	molecular_function	nickel cation binding
E	0016491	molecular_function	oxidoreductase activity
E	0050454	molecular_function	coenzyme F420 hydrogenase activity
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0051536	molecular_function	iron-sulfur cluster binding
E	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
F	0016151	molecular_function	nickel cation binding
F	0050454	molecular_function	coenzyme F420 hydrogenase activity
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0051536	molecular_function	iron-sulfur cluster binding
G	0008901	molecular_function	ferredoxin hydrogenase activity
G	0016151	molecular_function	nickel cation binding
G	0050454	molecular_function	coenzyme F420 hydrogenase activity
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0051536	molecular_function	iron-sulfur cluster binding
H	0016151	molecular_function	nickel cation binding
H	0016491	molecular_function	oxidoreductase activity
H	0050454	molecular_function	coenzyme F420 hydrogenase activity
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0051536	molecular_function	iron-sulfur cluster binding
H	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
I	0016151	molecular_function	nickel cation binding
I	0050454	molecular_function	coenzyme F420 hydrogenase activity
I	0050660	molecular_function	flavin adenine dinucleotide binding
I	0051536	molecular_function	iron-sulfur cluster binding
J	0008901	molecular_function	ferredoxin hydrogenase activity
J	0016151	molecular_function	nickel cation binding
J	0050454	molecular_function	coenzyme F420 hydrogenase activity
J	0050660	molecular_function	flavin adenine dinucleotide binding
J	0051536	molecular_function	iron-sulfur cluster binding
K	0016151	molecular_function	nickel cation binding
K	0016491	molecular_function	oxidoreductase activity
K	0050454	molecular_function	coenzyme F420 hydrogenase activity
K	0050660	molecular_function	flavin adenine dinucleotide binding
K	0051536	molecular_function	iron-sulfur cluster binding
K	0052592	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor
L	0016151	molecular_function	nickel cation binding
L	0050454	molecular_function	coenzyme F420 hydrogenase activity
L	0050660	molecular_function	flavin adenine dinucleotide binding
L	0051536	molecular_function	iron-sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CmGCGsCAaSCP

Chain	Residue	Details
C	CYS189-PRO200
C	CYS218-PRO229

---

site_id	PS00507
Number of Residues	26
Details	NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGFEkflvgkpaefapiavSRfCGIC

Chain	Residue	Details
A	ARG41-CYS66

---

site_id	PS00508
Number of Residues	10
Details	NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. YDPCISCat.H

Chain	Residue	Details
A	TYR384-HIS393

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---