9QWN
Human UPF1 in complex with the histone stem loop RNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 228 |
| Details | Domain: {"description":"UPF1-type SF1B helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 212 |
| Details | Domain: {"description":"UPF1-type SF1B helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01433","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Region: {"description":"C3H","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Region: {"description":"CC/SHH/C","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Region: {"description":"C4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01341","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19556969","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WJV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WJY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GK6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17159905","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21419344","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2GJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XZO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
