9QRU

Cryo-EM structure of the MMM ubiquitin ligase complex with nanobody 270 (Composite map)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0031647	biological_process	regulation of protein stability
A	0045664	biological_process	regulation of neuron differentiation
A	0045879	biological_process	negative regulation of smoothened signaling pathway
A	0060170	cellular_component	ciliary membrane
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005769	cellular_component	early endosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006513	biological_process	protein monoubiquitination
D	0007224	biological_process	smoothened signaling pathway
D	0008333	biological_process	endosome to lysosome transport
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0032100	biological_process	positive regulation of appetite
D	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
D	0045879	biological_process	negative regulation of smoothened signaling pathway
D	0048022	biological_process	negative regulation of melanin biosynthetic process
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0070062	cellular_component	extracellular exosome
D	0106072	biological_process	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
D	0140311	molecular_function	protein sequestering activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	102
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details