9QNA

RAD51 filament in complex with magnesium and ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000150	molecular_function	DNA strand exchange activity
A	0000166	molecular_function	nucleotide binding
A	0000228	cellular_component	nuclear chromosome
A	0000722	biological_process	telomere maintenance via recombination
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000730	biological_process	DNA recombinase assembly
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000793	cellular_component	condensed chromosome
A	0000794	cellular_component	condensed nuclear chromosome
A	0000800	cellular_component	lateral element
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006312	biological_process	mitotic recombination
A	0006974	biological_process	DNA damage response
A	0007127	biological_process	meiosis I
A	0007131	biological_process	reciprocal meiotic recombination
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0010165	biological_process	response to X-ray
A	0010569	biological_process	regulation of double-strand break repair via homologous recombination
A	0010833	biological_process	telomere maintenance via telomere lengthening
A	0016605	cellular_component	PML body
A	0016787	molecular_function	hydrolase activity
A	0017116	molecular_function	single-stranded DNA helicase activity
A	0019899	molecular_function	enzyme binding
A	0031297	biological_process	replication fork processing
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0035861	cellular_component	site of double-strand break
A	0036297	biological_process	interstrand cross-link repair
A	0042148	biological_process	DNA strand invasion
A	0042802	molecular_function	identical protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051321	biological_process	meiotic cell cycle
A	0070182	molecular_function	DNA polymerase binding
A	0070192	biological_process	chromosome organization involved in meiotic cell cycle
A	0071479	biological_process	cellular response to ionizing radiation
A	0071480	biological_process	cellular response to gamma radiation
A	0072719	biological_process	cellular response to cisplatin
A	0072757	biological_process	cellular response to camptothecin
A	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
A	1904631	biological_process	response to glucoside
A	1990918	biological_process	double-strand break repair involved in meiotic recombination
A	2000001	biological_process	regulation of DNA damage checkpoint
C	0000150	molecular_function	DNA strand exchange activity
C	0000166	molecular_function	nucleotide binding
C	0000228	cellular_component	nuclear chromosome
C	0000722	biological_process	telomere maintenance via recombination
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000730	biological_process	DNA recombinase assembly
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000793	cellular_component	condensed chromosome
C	0000794	cellular_component	condensed nuclear chromosome
C	0000800	cellular_component	lateral element
C	0003677	molecular_function	DNA binding
C	0003682	molecular_function	chromatin binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0006312	biological_process	mitotic recombination
C	0006974	biological_process	DNA damage response
C	0007127	biological_process	meiosis I
C	0007131	biological_process	reciprocal meiotic recombination
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0009410	biological_process	response to xenobiotic stimulus
C	0009636	biological_process	response to toxic substance
C	0010165	biological_process	response to X-ray
C	0010569	biological_process	regulation of double-strand break repair via homologous recombination
C	0010833	biological_process	telomere maintenance via telomere lengthening
C	0016605	cellular_component	PML body
C	0016787	molecular_function	hydrolase activity
C	0017116	molecular_function	single-stranded DNA helicase activity
C	0019899	molecular_function	enzyme binding
C	0031297	biological_process	replication fork processing
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0035861	cellular_component	site of double-strand break
C	0036297	biological_process	interstrand cross-link repair
C	0042148	biological_process	DNA strand invasion
C	0042802	molecular_function	identical protein binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051321	biological_process	meiotic cell cycle
C	0070182	molecular_function	DNA polymerase binding
C	0070192	biological_process	chromosome organization involved in meiotic cell cycle
C	0071479	biological_process	cellular response to ionizing radiation
C	0071480	biological_process	cellular response to gamma radiation
C	0072719	biological_process	cellular response to cisplatin
C	0072757	biological_process	cellular response to camptothecin
C	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
C	1904631	biological_process	response to glucoside
C	1990918	biological_process	double-strand break repair involved in meiotic recombination
C	2000001	biological_process	regulation of DNA damage checkpoint
E	0000150	molecular_function	DNA strand exchange activity
E	0000166	molecular_function	nucleotide binding
E	0000228	cellular_component	nuclear chromosome
E	0000722	biological_process	telomere maintenance via recombination
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000730	biological_process	DNA recombinase assembly
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000793	cellular_component	condensed chromosome
E	0000794	cellular_component	condensed nuclear chromosome
E	0000800	cellular_component	lateral element
E	0003677	molecular_function	DNA binding
E	0003682	molecular_function	chromatin binding
E	0003690	molecular_function	double-stranded DNA binding
E	0003697	molecular_function	single-stranded DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0006312	biological_process	mitotic recombination
E	0006974	biological_process	DNA damage response
E	0007127	biological_process	meiosis I
E	0007131	biological_process	reciprocal meiotic recombination
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0009410	biological_process	response to xenobiotic stimulus
E	0009636	biological_process	response to toxic substance
E	0010165	biological_process	response to X-ray
E	0010569	biological_process	regulation of double-strand break repair via homologous recombination
E	0010833	biological_process	telomere maintenance via telomere lengthening
E	0016605	cellular_component	PML body
E	0016787	molecular_function	hydrolase activity
E	0017116	molecular_function	single-stranded DNA helicase activity
E	0019899	molecular_function	enzyme binding
E	0031297	biological_process	replication fork processing
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0035861	cellular_component	site of double-strand break
E	0036297	biological_process	interstrand cross-link repair
E	0042148	biological_process	DNA strand invasion
E	0042802	molecular_function	identical protein binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051321	biological_process	meiotic cell cycle
E	0070182	molecular_function	DNA polymerase binding
E	0070192	biological_process	chromosome organization involved in meiotic cell cycle
E	0071479	biological_process	cellular response to ionizing radiation
E	0071480	biological_process	cellular response to gamma radiation
E	0072719	biological_process	cellular response to cisplatin
E	0072757	biological_process	cellular response to camptothecin
E	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
E	1904631	biological_process	response to glucoside
E	1990918	biological_process	double-strand break repair involved in meiotic recombination
E	2000001	biological_process	regulation of DNA damage checkpoint
G	0000150	molecular_function	DNA strand exchange activity
G	0000166	molecular_function	nucleotide binding
G	0000228	cellular_component	nuclear chromosome
G	0000722	biological_process	telomere maintenance via recombination
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000730	biological_process	DNA recombinase assembly
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0000793	cellular_component	condensed chromosome
G	0000794	cellular_component	condensed nuclear chromosome
G	0000800	cellular_component	lateral element
G	0003677	molecular_function	DNA binding
G	0003682	molecular_function	chromatin binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0006312	biological_process	mitotic recombination
G	0006974	biological_process	DNA damage response
G	0007127	biological_process	meiosis I
G	0007131	biological_process	reciprocal meiotic recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0009410	biological_process	response to xenobiotic stimulus
G	0009636	biological_process	response to toxic substance
G	0010165	biological_process	response to X-ray
G	0010569	biological_process	regulation of double-strand break repair via homologous recombination
G	0010833	biological_process	telomere maintenance via telomere lengthening
G	0016605	cellular_component	PML body
G	0016787	molecular_function	hydrolase activity
G	0017116	molecular_function	single-stranded DNA helicase activity
G	0019899	molecular_function	enzyme binding
G	0031297	biological_process	replication fork processing
G	0032991	cellular_component	protein-containing complex
G	0032993	cellular_component	protein-DNA complex
G	0035861	cellular_component	site of double-strand break
G	0036297	biological_process	interstrand cross-link repair
G	0042148	biological_process	DNA strand invasion
G	0042802	molecular_function	identical protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0051321	biological_process	meiotic cell cycle
G	0070182	molecular_function	DNA polymerase binding
G	0070192	biological_process	chromosome organization involved in meiotic cell cycle
G	0071479	biological_process	cellular response to ionizing radiation
G	0071480	biological_process	cellular response to gamma radiation
G	0072719	biological_process	cellular response to cisplatin
G	0072757	biological_process	cellular response to camptothecin
G	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
G	1904631	biological_process	response to glucoside
G	1990918	biological_process	double-strand break repair involved in meiotic recombination
G	2000001	biological_process	regulation of DNA damage checkpoint
I	0000150	molecular_function	DNA strand exchange activity
I	0000166	molecular_function	nucleotide binding
I	0000228	cellular_component	nuclear chromosome
I	0000722	biological_process	telomere maintenance via recombination
I	0000724	biological_process	double-strand break repair via homologous recombination
I	0000730	biological_process	DNA recombinase assembly
I	0000781	cellular_component	chromosome, telomeric region
I	0000785	cellular_component	chromatin
I	0000793	cellular_component	condensed chromosome
I	0000794	cellular_component	condensed nuclear chromosome
I	0000800	cellular_component	lateral element
I	0003677	molecular_function	DNA binding
I	0003682	molecular_function	chromatin binding
I	0003690	molecular_function	double-stranded DNA binding
I	0003697	molecular_function	single-stranded DNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006310	biological_process	DNA recombination
I	0006312	biological_process	mitotic recombination
I	0006974	biological_process	DNA damage response
I	0007127	biological_process	meiosis I
I	0007131	biological_process	reciprocal meiotic recombination
I	0008094	molecular_function	ATP-dependent activity, acting on DNA
I	0009410	biological_process	response to xenobiotic stimulus
I	0009636	biological_process	response to toxic substance
I	0010165	biological_process	response to X-ray
I	0010569	biological_process	regulation of double-strand break repair via homologous recombination
I	0010833	biological_process	telomere maintenance via telomere lengthening
I	0016605	cellular_component	PML body
I	0016787	molecular_function	hydrolase activity
I	0017116	molecular_function	single-stranded DNA helicase activity
I	0019899	molecular_function	enzyme binding
I	0031297	biological_process	replication fork processing
I	0032991	cellular_component	protein-containing complex
I	0032993	cellular_component	protein-DNA complex
I	0035861	cellular_component	site of double-strand break
I	0036297	biological_process	interstrand cross-link repair
I	0042148	biological_process	DNA strand invasion
I	0042802	molecular_function	identical protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0051321	biological_process	meiotic cell cycle
I	0070182	molecular_function	DNA polymerase binding
I	0070192	biological_process	chromosome organization involved in meiotic cell cycle
I	0071479	biological_process	cellular response to ionizing radiation
I	0071480	biological_process	cellular response to gamma radiation
I	0072719	biological_process	cellular response to cisplatin
I	0072757	biological_process	cellular response to camptothecin
I	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
I	1904631	biological_process	response to glucoside
I	1990918	biological_process	double-strand break repair involved in meiotic recombination
I	2000001	biological_process	regulation of DNA damage checkpoint
K	0000150	molecular_function	DNA strand exchange activity
K	0000166	molecular_function	nucleotide binding
K	0000228	cellular_component	nuclear chromosome
K	0000722	biological_process	telomere maintenance via recombination
K	0000724	biological_process	double-strand break repair via homologous recombination
K	0000730	biological_process	DNA recombinase assembly
K	0000781	cellular_component	chromosome, telomeric region
K	0000785	cellular_component	chromatin
K	0000793	cellular_component	condensed chromosome
K	0000794	cellular_component	condensed nuclear chromosome
K	0000800	cellular_component	lateral element
K	0003677	molecular_function	DNA binding
K	0003682	molecular_function	chromatin binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003697	molecular_function	single-stranded DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006310	biological_process	DNA recombination
K	0006312	biological_process	mitotic recombination
K	0006974	biological_process	DNA damage response
K	0007127	biological_process	meiosis I
K	0007131	biological_process	reciprocal meiotic recombination
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0009410	biological_process	response to xenobiotic stimulus
K	0009636	biological_process	response to toxic substance
K	0010165	biological_process	response to X-ray
K	0010569	biological_process	regulation of double-strand break repair via homologous recombination
K	0010833	biological_process	telomere maintenance via telomere lengthening
K	0016605	cellular_component	PML body
K	0016787	molecular_function	hydrolase activity
K	0017116	molecular_function	single-stranded DNA helicase activity
K	0019899	molecular_function	enzyme binding
K	0031297	biological_process	replication fork processing
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0035861	cellular_component	site of double-strand break
K	0036297	biological_process	interstrand cross-link repair
K	0042148	biological_process	DNA strand invasion
K	0042802	molecular_function	identical protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051321	biological_process	meiotic cell cycle
K	0070182	molecular_function	DNA polymerase binding
K	0070192	biological_process	chromosome organization involved in meiotic cell cycle
K	0071479	biological_process	cellular response to ionizing radiation
K	0071480	biological_process	cellular response to gamma radiation
K	0072719	biological_process	cellular response to cisplatin
K	0072757	biological_process	cellular response to camptothecin
K	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
K	1904631	biological_process	response to glucoside
K	1990918	biological_process	double-strand break repair involved in meiotic recombination
K	2000001	biological_process	regulation of DNA damage checkpoint

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	174
Details	Domain: {"description":"HhH"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	438
Details	Region: {"description":"Interaction with PALB2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	90
Details	Motif: {"description":"Nuclear export signal; masked by the interaction with BRCA2","evidences":[{"source":"PubMed","id":"24013206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"9461559","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by CHEK1","evidences":[{"source":"PubMed","id":"15665856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	18
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23393192","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---