9QMS

DNA-PK bound to 153 bp H2AX nucleosome with ATPyS

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000785	cellular_component	chromatin
a	0000786	cellular_component	nucleosome
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0006325	biological_process	chromatin organization
a	0006334	biological_process	nucleosome assembly
a	0016020	cellular_component	membrane
a	0030527	molecular_function	structural constituent of chromatin
a	0031492	molecular_function	nucleosomal DNA binding
a	0031507	biological_process	heterochromatin formation
a	0032200	biological_process	telomere organization
a	0032991	cellular_component	protein-containing complex
a	0040029	biological_process	epigenetic regulation of gene expression
a	0045296	molecular_function	cadherin binding
a	0070062	cellular_component	extracellular exosome
A	0000785	cellular_component	chromatin
A	0000786	cellular_component	nucleosome
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0016020	cellular_component	membrane
A	0030527	molecular_function	structural constituent of chromatin
A	0031492	molecular_function	nucleosomal DNA binding
A	0031507	biological_process	heterochromatin formation
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0045296	molecular_function	cadherin binding
A	0070062	cellular_component	extracellular exosome
b	0000781	cellular_component	chromosome, telomeric region
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0006325	biological_process	chromatin organization
b	0006334	biological_process	nucleosome assembly
b	0016020	cellular_component	membrane
b	0030527	molecular_function	structural constituent of chromatin
b	0032200	biological_process	telomere organization
b	0032991	cellular_component	protein-containing complex
b	0043505	cellular_component	CENP-A containing nucleosome
b	0045653	biological_process	negative regulation of megakaryocyte differentiation
b	0061644	biological_process	protein localization to CENP-A containing chromatin
b	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
c	0000077	biological_process	DNA damage checkpoint signaling
c	0000781	cellular_component	chromosome, telomeric region
c	0000785	cellular_component	chromatin
c	0000786	cellular_component	nucleosome
c	0000794	cellular_component	condensed nuclear chromosome
c	0001673	cellular_component	male germ cell nucleus
c	0001741	cellular_component	XY body
c	0003677	molecular_function	DNA binding
c	0003684	molecular_function	damaged DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005657	cellular_component	replication fork
c	0005694	cellular_component	chromosome
c	0005813	cellular_component	centrosome
c	0006302	biological_process	double-strand break repair
c	0006334	biological_process	nucleosome assembly
c	0006974	biological_process	DNA damage response
c	0010212	biological_process	response to ionizing radiation
c	0016607	cellular_component	nuclear speck
c	0019899	molecular_function	enzyme binding
c	0030527	molecular_function	structural constituent of chromatin
c	0031507	biological_process	heterochromatin formation
c	0035861	cellular_component	site of double-strand break
c	0042393	molecular_function	histone binding
c	0045739	biological_process	positive regulation of DNA repair
c	0070062	cellular_component	extracellular exosome
c	0090734	cellular_component	site of DNA damage
c	0140463	molecular_function	chromatin-protein adaptor activity
c	1990166	biological_process	protein localization to site of double-strand break
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000786	cellular_component	nucleosome
C	0000794	cellular_component	condensed nuclear chromosome
C	0001673	cellular_component	male germ cell nucleus
C	0001741	cellular_component	XY body
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005694	cellular_component	chromosome
C	0005813	cellular_component	centrosome
C	0006302	biological_process	double-strand break repair
C	0006334	biological_process	nucleosome assembly
C	0006974	biological_process	DNA damage response
C	0010212	biological_process	response to ionizing radiation
C	0016607	cellular_component	nuclear speck
C	0019899	molecular_function	enzyme binding
C	0030527	molecular_function	structural constituent of chromatin
C	0031507	biological_process	heterochromatin formation
C	0035861	cellular_component	site of double-strand break
C	0042393	molecular_function	histone binding
C	0045739	biological_process	positive regulation of DNA repair
C	0070062	cellular_component	extracellular exosome
C	0090734	cellular_component	site of DNA damage
C	0140463	molecular_function	chromatin-protein adaptor activity
C	1990166	biological_process	protein localization to site of double-strand break
d	0000786	cellular_component	nucleosome
d	0001530	molecular_function	lipopolysaccharide binding
d	0002227	biological_process	innate immune response in mucosa
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005576	cellular_component	extracellular region
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005886	cellular_component	plasma membrane
d	0006325	biological_process	chromatin organization
d	0006334	biological_process	nucleosome assembly
d	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
d	0019731	biological_process	antibacterial humoral response
d	0030527	molecular_function	structural constituent of chromatin
d	0031640	biological_process	killing of cells of another organism
d	0043505	cellular_component	CENP-A containing nucleosome
d	0050829	biological_process	defense response to Gram-negative bacterium
d	0050830	biological_process	defense response to Gram-positive bacterium
d	0061644	biological_process	protein localization to CENP-A containing chromatin
d	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0000786	cellular_component	nucleosome
D	0001530	molecular_function	lipopolysaccharide binding
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005886	cellular_component	plasma membrane
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0043505	cellular_component	CENP-A containing nucleosome
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
e	0000785	cellular_component	chromatin
e	0000786	cellular_component	nucleosome
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0006325	biological_process	chromatin organization
e	0006334	biological_process	nucleosome assembly
e	0016020	cellular_component	membrane
e	0030527	molecular_function	structural constituent of chromatin
e	0031492	molecular_function	nucleosomal DNA binding
e	0031507	biological_process	heterochromatin formation
e	0032200	biological_process	telomere organization
e	0032991	cellular_component	protein-containing complex
e	0040029	biological_process	epigenetic regulation of gene expression
e	0045296	molecular_function	cadherin binding
e	0070062	cellular_component	extracellular exosome
E	0000785	cellular_component	chromatin
E	0000786	cellular_component	nucleosome
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0031492	molecular_function	nucleosomal DNA binding
E	0031507	biological_process	heterochromatin formation
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0045296	molecular_function	cadherin binding
E	0070062	cellular_component	extracellular exosome
f	0000781	cellular_component	chromosome, telomeric region
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0006325	biological_process	chromatin organization
f	0006334	biological_process	nucleosome assembly
f	0016020	cellular_component	membrane
f	0030527	molecular_function	structural constituent of chromatin
f	0032200	biological_process	telomere organization
f	0032991	cellular_component	protein-containing complex
f	0043505	cellular_component	CENP-A containing nucleosome
f	0045653	biological_process	negative regulation of megakaryocyte differentiation
f	0061644	biological_process	protein localization to CENP-A containing chromatin
f	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
g	0000077	biological_process	DNA damage checkpoint signaling
g	0000781	cellular_component	chromosome, telomeric region
g	0000785	cellular_component	chromatin
g	0000786	cellular_component	nucleosome
g	0000794	cellular_component	condensed nuclear chromosome
g	0001673	cellular_component	male germ cell nucleus
g	0001741	cellular_component	XY body
g	0003677	molecular_function	DNA binding
g	0003684	molecular_function	damaged DNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005657	cellular_component	replication fork
g	0005694	cellular_component	chromosome
g	0005813	cellular_component	centrosome
g	0006302	biological_process	double-strand break repair
g	0006334	biological_process	nucleosome assembly
g	0006974	biological_process	DNA damage response
g	0010212	biological_process	response to ionizing radiation
g	0016607	cellular_component	nuclear speck
g	0019899	molecular_function	enzyme binding
g	0030527	molecular_function	structural constituent of chromatin
g	0031507	biological_process	heterochromatin formation
g	0035861	cellular_component	site of double-strand break
g	0042393	molecular_function	histone binding
g	0045739	biological_process	positive regulation of DNA repair
g	0070062	cellular_component	extracellular exosome
g	0090734	cellular_component	site of DNA damage
g	0140463	molecular_function	chromatin-protein adaptor activity
g	1990166	biological_process	protein localization to site of double-strand break
G	0000077	biological_process	DNA damage checkpoint signaling
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0000786	cellular_component	nucleosome
G	0000794	cellular_component	condensed nuclear chromosome
G	0001673	cellular_component	male germ cell nucleus
G	0001741	cellular_component	XY body
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005657	cellular_component	replication fork
G	0005694	cellular_component	chromosome
G	0005813	cellular_component	centrosome
G	0006302	biological_process	double-strand break repair
G	0006334	biological_process	nucleosome assembly
G	0006974	biological_process	DNA damage response
G	0010212	biological_process	response to ionizing radiation
G	0016607	cellular_component	nuclear speck
G	0019899	molecular_function	enzyme binding
G	0030527	molecular_function	structural constituent of chromatin
G	0031507	biological_process	heterochromatin formation
G	0035861	cellular_component	site of double-strand break
G	0042393	molecular_function	histone binding
G	0045739	biological_process	positive regulation of DNA repair
G	0070062	cellular_component	extracellular exosome
G	0090734	cellular_component	site of DNA damage
G	0140463	molecular_function	chromatin-protein adaptor activity
G	1990166	biological_process	protein localization to site of double-strand break
h	0000786	cellular_component	nucleosome
h	0001530	molecular_function	lipopolysaccharide binding
h	0002227	biological_process	innate immune response in mucosa
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005576	cellular_component	extracellular region
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0005886	cellular_component	plasma membrane
h	0006325	biological_process	chromatin organization
h	0006334	biological_process	nucleosome assembly
h	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
h	0019731	biological_process	antibacterial humoral response
h	0030527	molecular_function	structural constituent of chromatin
h	0031640	biological_process	killing of cells of another organism
h	0043505	cellular_component	CENP-A containing nucleosome
h	0050829	biological_process	defense response to Gram-negative bacterium
h	0050830	biological_process	defense response to Gram-positive bacterium
h	0061644	biological_process	protein localization to CENP-A containing chromatin
h	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0000786	cellular_component	nucleosome
H	0001530	molecular_function	lipopolysaccharide binding
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005886	cellular_component	plasma membrane
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0043505	cellular_component	CENP-A containing nucleosome
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
k	0000723	biological_process	telomere maintenance
k	0000725	biological_process	recombinational repair
k	0000781	cellular_component	chromosome, telomeric region
k	0000783	cellular_component	nuclear telomere cap complex
k	0000976	molecular_function	transcription cis-regulatory region binding
k	0002218	biological_process	activation of innate immune response
k	0002376	biological_process	immune system process
k	0002684	biological_process	positive regulation of immune system process
k	0003677	molecular_function	DNA binding
k	0003678	molecular_function	DNA helicase activity
k	0003690	molecular_function	double-stranded DNA binding
k	0003691	molecular_function	double-stranded telomeric DNA binding
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005576	cellular_component	extracellular region
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005667	cellular_component	transcription regulator complex
k	0005694	cellular_component	chromosome
k	0005730	cellular_component	nucleolus
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
k	0006303	biological_process	double-strand break repair via nonhomologous end joining
k	0008094	molecular_function	ATP-dependent activity, acting on DNA
k	0010212	biological_process	response to ionizing radiation
k	0016020	cellular_component	membrane
k	0016887	molecular_function	ATP hydrolysis activity
k	0030332	molecular_function	cyclin binding
k	0032991	cellular_component	protein-containing complex
k	0032993	cellular_component	protein-DNA complex
k	0034774	cellular_component	secretory granule lumen
k	0042162	molecular_function	telomeric repeat DNA binding
k	0043138	molecular_function	3'-5' DNA helicase activity
k	0043564	cellular_component	Ku70:Ku80 complex
k	0044877	molecular_function	protein-containing complex binding
k	0045027	molecular_function	DNA end binding
k	0045621	biological_process	positive regulation of lymphocyte differentiation
k	0045892	biological_process	negative regulation of DNA-templated transcription
k	0045893	biological_process	positive regulation of DNA-templated transcription
k	0045944	biological_process	positive regulation of transcription by RNA polymerase II
k	0048660	biological_process	regulation of smooth muscle cell proliferation
k	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
k	0070418	cellular_component	DNA-dependent protein kinase complex
k	0070419	cellular_component	nonhomologous end joining complex
k	0071475	biological_process	cellular hyperosmotic salinity response
k	0071480	biological_process	cellular response to gamma radiation
k	0071481	biological_process	cellular response to X-ray
k	0097110	molecular_function	scaffold protein binding
k	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
k	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
k	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000723	biological_process	telomere maintenance
K	0000725	biological_process	recombinational repair
K	0000781	cellular_component	chromosome, telomeric region
K	0000783	cellular_component	nuclear telomere cap complex
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0002218	biological_process	activation of innate immune response
K	0002376	biological_process	immune system process
K	0002684	biological_process	positive regulation of immune system process
K	0003677	molecular_function	DNA binding
K	0003678	molecular_function	DNA helicase activity
K	0003690	molecular_function	double-stranded DNA binding
K	0003691	molecular_function	double-stranded telomeric DNA binding
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005667	cellular_component	transcription regulator complex
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
K	0006303	biological_process	double-strand break repair via nonhomologous end joining
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0010212	biological_process	response to ionizing radiation
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0030332	molecular_function	cyclin binding
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0034774	cellular_component	secretory granule lumen
K	0042162	molecular_function	telomeric repeat DNA binding
K	0043138	molecular_function	3'-5' DNA helicase activity
K	0043564	cellular_component	Ku70:Ku80 complex
K	0044877	molecular_function	protein-containing complex binding
K	0045027	molecular_function	DNA end binding
K	0045621	biological_process	positive regulation of lymphocyte differentiation
K	0045892	biological_process	negative regulation of DNA-templated transcription
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0045944	biological_process	positive regulation of transcription by RNA polymerase II
K	0048660	biological_process	regulation of smooth muscle cell proliferation
K	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
K	0070418	cellular_component	DNA-dependent protein kinase complex
K	0070419	cellular_component	nonhomologous end joining complex
K	0071475	biological_process	cellular hyperosmotic salinity response
K	0071480	biological_process	cellular response to gamma radiation
K	0071481	biological_process	cellular response to X-ray
K	0097110	molecular_function	scaffold protein binding
K	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
K	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K	1904813	cellular_component	ficolin-1-rich granule lumen
l	0000725	biological_process	recombinational repair
l	0000781	cellular_component	chromosome, telomeric region
l	0000783	cellular_component	nuclear telomere cap complex
l	0000976	molecular_function	transcription cis-regulatory region binding
l	0002218	biological_process	activation of innate immune response
l	0003677	molecular_function	DNA binding
l	0003678	molecular_function	DNA helicase activity
l	0003690	molecular_function	double-stranded DNA binding
l	0003691	molecular_function	double-stranded telomeric DNA binding
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005576	cellular_component	extracellular region
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005694	cellular_component	chromosome
l	0005730	cellular_component	nucleolus
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
l	0006302	biological_process	double-strand break repair
l	0006303	biological_process	double-strand break repair via nonhomologous end joining
l	0006310	biological_process	DNA recombination
l	0006974	biological_process	DNA damage response
l	0007004	biological_process	telomere maintenance via telomerase
l	0008047	molecular_function	enzyme activator activity
l	0008094	molecular_function	ATP-dependent activity, acting on DNA
l	0016020	cellular_component	membrane
l	0016887	molecular_function	ATP hydrolysis activity
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0032040	cellular_component	small-subunit processome
l	0032204	biological_process	regulation of telomere maintenance
l	0032991	cellular_component	protein-containing complex
l	0032993	cellular_component	protein-DNA complex
l	0034462	biological_process	small-subunit processome assembly
l	0034511	molecular_function	U3 snoRNA binding
l	0034774	cellular_component	secretory granule lumen
l	0042162	molecular_function	telomeric repeat DNA binding
l	0043138	molecular_function	3'-5' DNA helicase activity
l	0043564	cellular_component	Ku70:Ku80 complex
l	0044877	molecular_function	protein-containing complex binding
l	0045027	molecular_function	DNA end binding
l	0045892	biological_process	negative regulation of DNA-templated transcription
l	0048660	biological_process	regulation of smooth muscle cell proliferation
l	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
l	0070198	biological_process	protein localization to chromosome, telomeric region
l	0070418	cellular_component	DNA-dependent protein kinase complex
l	0070419	cellular_component	nonhomologous end joining complex
l	0071480	biological_process	cellular response to gamma radiation
l	0090734	cellular_component	site of DNA damage
l	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
l	1904430	biological_process	negative regulation of t-circle formation
l	1990904	cellular_component	ribonucleoprotein complex
L	0000725	biological_process	recombinational repair
L	0000781	cellular_component	chromosome, telomeric region
L	0000783	cellular_component	nuclear telomere cap complex
L	0000976	molecular_function	transcription cis-regulatory region binding
L	0002218	biological_process	activation of innate immune response
L	0003677	molecular_function	DNA binding
L	0003678	molecular_function	DNA helicase activity
L	0003690	molecular_function	double-stranded DNA binding
L	0003691	molecular_function	double-stranded telomeric DNA binding
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
L	0006302	biological_process	double-strand break repair
L	0006303	biological_process	double-strand break repair via nonhomologous end joining
L	0006310	biological_process	DNA recombination
L	0006974	biological_process	DNA damage response
L	0007004	biological_process	telomere maintenance via telomerase
L	0008047	molecular_function	enzyme activator activity
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032040	cellular_component	small-subunit processome
L	0032204	biological_process	regulation of telomere maintenance
L	0032991	cellular_component	protein-containing complex
L	0032993	cellular_component	protein-DNA complex
L	0034462	biological_process	small-subunit processome assembly
L	0034511	molecular_function	U3 snoRNA binding
L	0034774	cellular_component	secretory granule lumen
L	0042162	molecular_function	telomeric repeat DNA binding
L	0043138	molecular_function	3'-5' DNA helicase activity
L	0043564	cellular_component	Ku70:Ku80 complex
L	0044877	molecular_function	protein-containing complex binding
L	0045027	molecular_function	DNA end binding
L	0045892	biological_process	negative regulation of DNA-templated transcription
L	0048660	biological_process	regulation of smooth muscle cell proliferation
L	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
L	0070198	biological_process	protein localization to chromosome, telomeric region
L	0070418	cellular_component	DNA-dependent protein kinase complex
L	0070419	cellular_component	nonhomologous end joining complex
L	0071480	biological_process	cellular response to gamma radiation
L	0090734	cellular_component	site of DNA damage
L	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L	1904430	biological_process	negative regulation of t-circle formation
L	1990904	cellular_component	ribonucleoprotein complex
m	0000723	biological_process	telomere maintenance
m	0000725	biological_process	recombinational repair
m	0000781	cellular_component	chromosome, telomeric region
m	0000783	cellular_component	nuclear telomere cap complex
m	0000976	molecular_function	transcription cis-regulatory region binding
m	0002218	biological_process	activation of innate immune response
m	0002376	biological_process	immune system process
m	0002684	biological_process	positive regulation of immune system process
m	0003677	molecular_function	DNA binding
m	0003678	molecular_function	DNA helicase activity
m	0003690	molecular_function	double-stranded DNA binding
m	0003691	molecular_function	double-stranded telomeric DNA binding
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005576	cellular_component	extracellular region
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005667	cellular_component	transcription regulator complex
m	0005694	cellular_component	chromosome
m	0005730	cellular_component	nucleolus
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
m	0006303	biological_process	double-strand break repair via nonhomologous end joining
m	0008094	molecular_function	ATP-dependent activity, acting on DNA
m	0010212	biological_process	response to ionizing radiation
m	0016020	cellular_component	membrane
m	0016887	molecular_function	ATP hydrolysis activity
m	0030332	molecular_function	cyclin binding
m	0032991	cellular_component	protein-containing complex
m	0032993	cellular_component	protein-DNA complex
m	0034774	cellular_component	secretory granule lumen
m	0042162	molecular_function	telomeric repeat DNA binding
m	0043138	molecular_function	3'-5' DNA helicase activity
m	0043564	cellular_component	Ku70:Ku80 complex
m	0044877	molecular_function	protein-containing complex binding
m	0045027	molecular_function	DNA end binding
m	0045621	biological_process	positive regulation of lymphocyte differentiation
m	0045892	biological_process	negative regulation of DNA-templated transcription
m	0045893	biological_process	positive regulation of DNA-templated transcription
m	0045944	biological_process	positive regulation of transcription by RNA polymerase II
m	0048660	biological_process	regulation of smooth muscle cell proliferation
m	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
m	0070418	cellular_component	DNA-dependent protein kinase complex
m	0070419	cellular_component	nonhomologous end joining complex
m	0071475	biological_process	cellular hyperosmotic salinity response
m	0071480	biological_process	cellular response to gamma radiation
m	0071481	biological_process	cellular response to X-ray
m	0097110	molecular_function	scaffold protein binding
m	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
m	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
m	1904813	cellular_component	ficolin-1-rich granule lumen
M	0000723	biological_process	telomere maintenance
M	0000725	biological_process	recombinational repair
M	0000781	cellular_component	chromosome, telomeric region
M	0000783	cellular_component	nuclear telomere cap complex
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0002218	biological_process	activation of innate immune response
M	0002376	biological_process	immune system process
M	0002684	biological_process	positive regulation of immune system process
M	0003677	molecular_function	DNA binding
M	0003678	molecular_function	DNA helicase activity
M	0003690	molecular_function	double-stranded DNA binding
M	0003691	molecular_function	double-stranded telomeric DNA binding
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005667	cellular_component	transcription regulator complex
M	0005694	cellular_component	chromosome
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
M	0006303	biological_process	double-strand break repair via nonhomologous end joining
M	0008094	molecular_function	ATP-dependent activity, acting on DNA
M	0010212	biological_process	response to ionizing radiation
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0030332	molecular_function	cyclin binding
M	0032991	cellular_component	protein-containing complex
M	0032993	cellular_component	protein-DNA complex
M	0034774	cellular_component	secretory granule lumen
M	0042162	molecular_function	telomeric repeat DNA binding
M	0043138	molecular_function	3'-5' DNA helicase activity
M	0043564	cellular_component	Ku70:Ku80 complex
M	0044877	molecular_function	protein-containing complex binding
M	0045027	molecular_function	DNA end binding
M	0045621	biological_process	positive regulation of lymphocyte differentiation
M	0045892	biological_process	negative regulation of DNA-templated transcription
M	0045893	biological_process	positive regulation of DNA-templated transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0048660	biological_process	regulation of smooth muscle cell proliferation
M	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
M	0070418	cellular_component	DNA-dependent protein kinase complex
M	0070419	cellular_component	nonhomologous end joining complex
M	0071475	biological_process	cellular hyperosmotic salinity response
M	0071480	biological_process	cellular response to gamma radiation
M	0071481	biological_process	cellular response to X-ray
M	0097110	molecular_function	scaffold protein binding
M	0097680	biological_process	double-strand break repair via classical nonhomologous end joining
M	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M	1904813	cellular_component	ficolin-1-rich granule lumen
n	0000725	biological_process	recombinational repair
n	0000781	cellular_component	chromosome, telomeric region
n	0000783	cellular_component	nuclear telomere cap complex
n	0000976	molecular_function	transcription cis-regulatory region binding
n	0002218	biological_process	activation of innate immune response
n	0003677	molecular_function	DNA binding
n	0003678	molecular_function	DNA helicase activity
n	0003690	molecular_function	double-stranded DNA binding
n	0003691	molecular_function	double-stranded telomeric DNA binding
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005576	cellular_component	extracellular region
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005694	cellular_component	chromosome
n	0005730	cellular_component	nucleolus
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
n	0006302	biological_process	double-strand break repair
n	0006303	biological_process	double-strand break repair via nonhomologous end joining
n	0006310	biological_process	DNA recombination
n	0006974	biological_process	DNA damage response
n	0007004	biological_process	telomere maintenance via telomerase
n	0008047	molecular_function	enzyme activator activity
n	0008094	molecular_function	ATP-dependent activity, acting on DNA
n	0016020	cellular_component	membrane
n	0016887	molecular_function	ATP hydrolysis activity
n	0031625	molecular_function	ubiquitin protein ligase binding
n	0032040	cellular_component	small-subunit processome
n	0032204	biological_process	regulation of telomere maintenance
n	0032991	cellular_component	protein-containing complex
n	0032993	cellular_component	protein-DNA complex
n	0034462	biological_process	small-subunit processome assembly
n	0034511	molecular_function	U3 snoRNA binding
n	0034774	cellular_component	secretory granule lumen
n	0042162	molecular_function	telomeric repeat DNA binding
n	0043138	molecular_function	3'-5' DNA helicase activity
n	0043564	cellular_component	Ku70:Ku80 complex
n	0044877	molecular_function	protein-containing complex binding
n	0045027	molecular_function	DNA end binding
n	0045892	biological_process	negative regulation of DNA-templated transcription
n	0048660	biological_process	regulation of smooth muscle cell proliferation
n	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
n	0070198	biological_process	protein localization to chromosome, telomeric region
n	0070418	cellular_component	DNA-dependent protein kinase complex
n	0070419	cellular_component	nonhomologous end joining complex
n	0071480	biological_process	cellular response to gamma radiation
n	0090734	cellular_component	site of DNA damage
n	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
n	1904430	biological_process	negative regulation of t-circle formation
n	1990904	cellular_component	ribonucleoprotein complex
N	0000725	biological_process	recombinational repair
N	0000781	cellular_component	chromosome, telomeric region
N	0000783	cellular_component	nuclear telomere cap complex
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0002218	biological_process	activation of innate immune response
N	0003677	molecular_function	DNA binding
N	0003678	molecular_function	DNA helicase activity
N	0003690	molecular_function	double-stranded DNA binding
N	0003691	molecular_function	double-stranded telomeric DNA binding
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0005730	cellular_component	nucleolus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
N	0006302	biological_process	double-strand break repair
N	0006303	biological_process	double-strand break repair via nonhomologous end joining
N	0006310	biological_process	DNA recombination
N	0006974	biological_process	DNA damage response
N	0007004	biological_process	telomere maintenance via telomerase
N	0008047	molecular_function	enzyme activator activity
N	0008094	molecular_function	ATP-dependent activity, acting on DNA
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0032040	cellular_component	small-subunit processome
N	0032204	biological_process	regulation of telomere maintenance
N	0032991	cellular_component	protein-containing complex
N	0032993	cellular_component	protein-DNA complex
N	0034462	biological_process	small-subunit processome assembly
N	0034511	molecular_function	U3 snoRNA binding
N	0034774	cellular_component	secretory granule lumen
N	0042162	molecular_function	telomeric repeat DNA binding
N	0043138	molecular_function	3'-5' DNA helicase activity
N	0043564	cellular_component	Ku70:Ku80 complex
N	0044877	molecular_function	protein-containing complex binding
N	0045027	molecular_function	DNA end binding
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0048660	biological_process	regulation of smooth muscle cell proliferation
N	0051575	molecular_function	5'-deoxyribose-5-phosphate lyase activity
N	0070198	biological_process	protein localization to chromosome, telomeric region
N	0070418	cellular_component	DNA-dependent protein kinase complex
N	0070419	cellular_component	nonhomologous end joining complex
N	0071480	biological_process	cellular response to gamma radiation
N	0090734	cellular_component	site of DNA damage
N	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N	1904430	biological_process	negative regulation of t-circle formation
N	1990904	cellular_component	ribonucleoprotein complex
o	0000460	biological_process	maturation of 5.8S rRNA
o	0000723	biological_process	telomere maintenance
o	0000781	cellular_component	chromosome, telomeric region
o	0000785	cellular_component	chromatin
o	0001933	biological_process	negative regulation of protein phosphorylation
o	0002218	biological_process	activation of innate immune response
o	0003690	molecular_function	double-stranded DNA binding
o	0003723	molecular_function	RNA binding
o	0004672	molecular_function	protein kinase activity
o	0004674	molecular_function	protein serine/threonine kinase activity
o	0004677	molecular_function	DNA-dependent protein kinase activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005667	cellular_component	transcription regulator complex
o	0005730	cellular_component	nucleolus
o	0005829	cellular_component	cytosol
o	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
o	0006302	biological_process	double-strand break repair
o	0006303	biological_process	double-strand break repair via nonhomologous end joining
o	0006338	biological_process	chromatin remodeling
o	0006468	biological_process	protein phosphorylation
o	0006974	biological_process	DNA damage response
o	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
o	0016020	cellular_component	membrane
o	0016233	biological_process	telomere capping
o	0018105	biological_process	peptidyl-serine phosphorylation
o	0018107	biological_process	peptidyl-threonine phosphorylation
o	0019899	molecular_function	enzyme binding
o	0019904	molecular_function	protein domain specific binding
o	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
o	0032040	cellular_component	small-subunit processome
o	0032869	biological_process	cellular response to insulin stimulus
o	0032991	cellular_component	protein-containing complex
o	0032993	cellular_component	protein-DNA complex
o	0033152	biological_process	immunoglobulin V(D)J recombination
o	0034462	biological_process	small-subunit processome assembly
o	0034511	molecular_function	U3 snoRNA binding
o	0035979	molecular_function	histone H2AXS139 kinase activity
o	0036211	biological_process	protein modification process
o	0042752	biological_process	regulation of circadian rhythm
o	0043066	biological_process	negative regulation of apoptotic process
o	0045621	biological_process	positive regulation of lymphocyte differentiation
o	0045648	biological_process	positive regulation of erythrocyte differentiation
o	0045727	biological_process	positive regulation of translation
o	0045944	biological_process	positive regulation of transcription by RNA polymerase II
o	0048660	biological_process	regulation of smooth muscle cell proliferation
o	0050678	biological_process	regulation of epithelial cell proliferation
o	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
o	0070418	cellular_component	DNA-dependent protein kinase complex
o	0070419	cellular_component	nonhomologous end joining complex
o	0080135	biological_process	regulation of cellular response to stress
o	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
o	0106310	molecular_function	protein serine kinase activity
o	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
o	1902036	biological_process	regulation of hematopoietic stem cell differentiation
o	1905221	biological_process	positive regulation of platelet formation
o	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining
O	0000460	biological_process	maturation of 5.8S rRNA
O	0000723	biological_process	telomere maintenance
O	0000781	cellular_component	chromosome, telomeric region
O	0000785	cellular_component	chromatin
O	0001933	biological_process	negative regulation of protein phosphorylation
O	0002218	biological_process	activation of innate immune response
O	0003690	molecular_function	double-stranded DNA binding
O	0003723	molecular_function	RNA binding
O	0004672	molecular_function	protein kinase activity
O	0004674	molecular_function	protein serine/threonine kinase activity
O	0004677	molecular_function	DNA-dependent protein kinase activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005667	cellular_component	transcription regulator complex
O	0005730	cellular_component	nucleolus
O	0005829	cellular_component	cytosol
O	0005958	cellular_component	DNA-dependent protein kinase-DNA ligase 4 complex
O	0006302	biological_process	double-strand break repair
O	0006303	biological_process	double-strand break repair via nonhomologous end joining
O	0006338	biological_process	chromatin remodeling
O	0006468	biological_process	protein phosphorylation
O	0006974	biological_process	DNA damage response
O	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
O	0016020	cellular_component	membrane
O	0016233	biological_process	telomere capping
O	0018105	biological_process	peptidyl-serine phosphorylation
O	0018107	biological_process	peptidyl-threonine phosphorylation
O	0019899	molecular_function	enzyme binding
O	0019904	molecular_function	protein domain specific binding
O	0031571	biological_process	mitotic G1 DNA damage checkpoint signaling
O	0032040	cellular_component	small-subunit processome
O	0032869	biological_process	cellular response to insulin stimulus
O	0032991	cellular_component	protein-containing complex
O	0032993	cellular_component	protein-DNA complex
O	0033152	biological_process	immunoglobulin V(D)J recombination
O	0034462	biological_process	small-subunit processome assembly
O	0034511	molecular_function	U3 snoRNA binding
O	0035979	molecular_function	histone H2AXS139 kinase activity
O	0036211	biological_process	protein modification process
O	0042752	biological_process	regulation of circadian rhythm
O	0043066	biological_process	negative regulation of apoptotic process
O	0045621	biological_process	positive regulation of lymphocyte differentiation
O	0045648	biological_process	positive regulation of erythrocyte differentiation
O	0045727	biological_process	positive regulation of translation
O	0045944	biological_process	positive regulation of transcription by RNA polymerase II
O	0048660	biological_process	regulation of smooth muscle cell proliferation
O	0050678	biological_process	regulation of epithelial cell proliferation
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
O	0070418	cellular_component	DNA-dependent protein kinase complex
O	0070419	cellular_component	nonhomologous end joining complex
O	0080135	biological_process	regulation of cellular response to stress
O	0097681	biological_process	double-strand break repair via alternative nonhomologous end joining
O	0106310	molecular_function	protein serine kinase activity
O	0160049	biological_process	negative regulation of cGAS/STING signaling pathway
O	1902036	biological_process	regulation of hematopoietic stem cell differentiation
O	1905221	biological_process	positive regulation of platelet formation
O	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG89-GLY111

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	70
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	66
Details	Repeat: {"description":"TPR 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Repeat: {"description":"TPR 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	66
Details	Repeat: {"description":"TPR 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	64
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	143
Details	Region: {"description":"Leucine-zipper"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	50
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	38
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	796
Details	Domain: {"description":"Ku","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	32
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	8
Details	Motif: {"description":"EEXXXDL motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PRKDC","evidences":[{"source":"PubMed","id":"10026262","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P27661","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22980979","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	27
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	8
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"N6-isonicotinyllysine; alternate","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	4
Details	Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	8
Details	Modified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"PubMed","id":"34961760","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	8
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"UniProtKB","id":"P62807","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"21726816","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19783980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16267050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20850016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P84243","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q71DI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	4
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"31542297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27436229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	4
Details	Modified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"PubMed","id":"17267393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"PubMed","id":"21724829","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"PubMed","id":"30886146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"19818714","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	828
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	256
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	436
Details	Region: {"description":"Interaction with XRCC5","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PRKDC","evidences":[{"source":"PubMed","id":"9362500","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"15023334","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---