9QFE

Cryo-EM structure of the actin filament hetero-decorated by Coronin-1 and Cofilin-1 on separate actin strands

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000776	cellular_component	kinetochore
A	0000785	cellular_component	chromatin
A	0001738	biological_process	morphogenesis of a polarized epithelium
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0005911	cellular_component	cell-cell junction
A	0005912	cellular_component	adherens junction
A	0005925	cellular_component	focal adhesion
A	0006338	biological_process	chromatin remodeling
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0007010	biological_process	cytoskeleton organization
A	0007020	biological_process	microtubule nucleation
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007409	biological_process	axonogenesis
A	0008284	biological_process	positive regulation of cell population proliferation
A	0015629	cellular_component	actin cytoskeleton
A	0016020	cellular_component	membrane
A	0016363	cellular_component	nuclear matrix
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0019894	molecular_function	kinesin binding
A	0019901	molecular_function	protein kinase binding
A	0021762	biological_process	substantia nigra development
A	0030027	cellular_component	lamellipodium
A	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
A	0030235	molecular_function	nitric-oxide synthase regulator activity
A	0030424	cellular_component	axon
A	0030863	cellular_component	cortical cytoskeleton
A	0030957	molecular_function	Tat protein binding
A	0031492	molecular_function	nucleosomal DNA binding
A	0031982	cellular_component	vesicle
A	0032991	cellular_component	protein-containing complex
A	0034333	biological_process	adherens junction assembly
A	0035267	cellular_component	NuA4 histone acetyltransferase complex
A	0035633	biological_process	maintenance of blood-brain barrier
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0042981	biological_process	regulation of apoptotic process
A	0043296	cellular_component	apical junction complex
A	0044305	cellular_component	calyx of Held
A	0045176	biological_process	apical protein localization
A	0045202	cellular_component	synapse
A	0045582	biological_process	positive regulation of T cell differentiation
A	0045596	biological_process	negative regulation of cell differentiation
A	0045597	biological_process	positive regulation of cell differentiation
A	0045663	biological_process	positive regulation of myoblast differentiation
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0048156	molecular_function	tau protein binding
A	0048870	biological_process	cell motility
A	0050998	molecular_function	nitric-oxide synthase binding
A	0051621	biological_process	regulation of norepinephrine uptake
A	0051623	biological_process	positive regulation of norepinephrine uptake
A	0051726	biological_process	regulation of cell cycle
A	0070062	cellular_component	extracellular exosome
A	0070160	cellular_component	tight junction
A	0070316	biological_process	regulation of G0 to G1 transition
A	0070527	biological_process	platelet aggregation
A	0071896	biological_process	protein localization to adherens junction
A	0072562	cellular_component	blood microparticle
A	0072749	biological_process	cellular response to cytochalasin B
A	0097433	cellular_component	dense body
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098793	cellular_component	presynapse
A	0098871	cellular_component	postsynaptic actin cytoskeleton
A	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
A	0098974	biological_process	postsynaptic actin cytoskeleton organization
A	0098978	cellular_component	glutamatergic synapse
A	0141108	molecular_function	transporter regulator activity
A	0150111	biological_process	regulation of transepithelial transport
A	1900242	biological_process	regulation of synaptic vesicle endocytosis
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1903076	biological_process	regulation of protein localization to plasma membrane
A	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
A	1990904	cellular_component	ribonucleoprotein complex
A	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
A	2000779	biological_process	regulation of double-strand break repair
A	2000781	biological_process	positive regulation of double-strand break repair
A	2000819	biological_process	regulation of nucleotide-excision repair
B	0000166	molecular_function	nucleotide binding
B	0000776	cellular_component	kinetochore
B	0000785	cellular_component	chromatin
B	0001738	biological_process	morphogenesis of a polarized epithelium
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0005911	cellular_component	cell-cell junction
B	0005912	cellular_component	adherens junction
B	0005925	cellular_component	focal adhesion
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0007010	biological_process	cytoskeleton organization
B	0007020	biological_process	microtubule nucleation
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0007409	biological_process	axonogenesis
B	0008284	biological_process	positive regulation of cell population proliferation
B	0015629	cellular_component	actin cytoskeleton
B	0016020	cellular_component	membrane
B	0016363	cellular_component	nuclear matrix
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0019894	molecular_function	kinesin binding
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030027	cellular_component	lamellipodium
B	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
B	0030235	molecular_function	nitric-oxide synthase regulator activity
B	0030424	cellular_component	axon
B	0030863	cellular_component	cortical cytoskeleton
B	0030957	molecular_function	Tat protein binding
B	0031492	molecular_function	nucleosomal DNA binding
B	0031982	cellular_component	vesicle
B	0032991	cellular_component	protein-containing complex
B	0034333	biological_process	adherens junction assembly
B	0035267	cellular_component	NuA4 histone acetyltransferase complex
B	0035633	biological_process	maintenance of blood-brain barrier
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0042802	molecular_function	identical protein binding
B	0042981	biological_process	regulation of apoptotic process
B	0043296	cellular_component	apical junction complex
B	0044305	cellular_component	calyx of Held
B	0045176	biological_process	apical protein localization
B	0045202	cellular_component	synapse
B	0045582	biological_process	positive regulation of T cell differentiation
B	0045596	biological_process	negative regulation of cell differentiation
B	0045597	biological_process	positive regulation of cell differentiation
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048156	molecular_function	tau protein binding
B	0048870	biological_process	cell motility
B	0050998	molecular_function	nitric-oxide synthase binding
B	0051621	biological_process	regulation of norepinephrine uptake
B	0051623	biological_process	positive regulation of norepinephrine uptake
B	0051726	biological_process	regulation of cell cycle
B	0070062	cellular_component	extracellular exosome
B	0070160	cellular_component	tight junction
B	0070316	biological_process	regulation of G0 to G1 transition
B	0070527	biological_process	platelet aggregation
B	0071896	biological_process	protein localization to adherens junction
B	0072562	cellular_component	blood microparticle
B	0072749	biological_process	cellular response to cytochalasin B
B	0097433	cellular_component	dense body
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098793	cellular_component	presynapse
B	0098871	cellular_component	postsynaptic actin cytoskeleton
B	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
B	0098974	biological_process	postsynaptic actin cytoskeleton organization
B	0098978	cellular_component	glutamatergic synapse
B	0141108	molecular_function	transporter regulator activity
B	0150111	biological_process	regulation of transepithelial transport
B	1900242	biological_process	regulation of synaptic vesicle endocytosis
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1903076	biological_process	regulation of protein localization to plasma membrane
B	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
B	1990904	cellular_component	ribonucleoprotein complex
B	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
B	2000779	biological_process	regulation of double-strand break repair
B	2000781	biological_process	positive regulation of double-strand break repair
B	2000819	biological_process	regulation of nucleotide-excision repair
C	0000166	molecular_function	nucleotide binding
C	0000776	cellular_component	kinetochore
C	0000785	cellular_component	chromatin
C	0001738	biological_process	morphogenesis of a polarized epithelium
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0005886	cellular_component	plasma membrane
C	0005903	cellular_component	brush border
C	0005911	cellular_component	cell-cell junction
C	0005912	cellular_component	adherens junction
C	0005925	cellular_component	focal adhesion
C	0006338	biological_process	chromatin remodeling
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0007010	biological_process	cytoskeleton organization
C	0007020	biological_process	microtubule nucleation
C	0007163	biological_process	establishment or maintenance of cell polarity
C	0007409	biological_process	axonogenesis
C	0008284	biological_process	positive regulation of cell population proliferation
C	0015629	cellular_component	actin cytoskeleton
C	0016020	cellular_component	membrane
C	0016363	cellular_component	nuclear matrix
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0019894	molecular_function	kinesin binding
C	0019901	molecular_function	protein kinase binding
C	0021762	biological_process	substantia nigra development
C	0030027	cellular_component	lamellipodium
C	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
C	0030235	molecular_function	nitric-oxide synthase regulator activity
C	0030424	cellular_component	axon
C	0030863	cellular_component	cortical cytoskeleton
C	0030957	molecular_function	Tat protein binding
C	0031492	molecular_function	nucleosomal DNA binding
C	0031982	cellular_component	vesicle
C	0032991	cellular_component	protein-containing complex
C	0034333	biological_process	adherens junction assembly
C	0035267	cellular_component	NuA4 histone acetyltransferase complex
C	0035633	biological_process	maintenance of blood-brain barrier
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042802	molecular_function	identical protein binding
C	0042981	biological_process	regulation of apoptotic process
C	0043296	cellular_component	apical junction complex
C	0044305	cellular_component	calyx of Held
C	0045176	biological_process	apical protein localization
C	0045202	cellular_component	synapse
C	0045582	biological_process	positive regulation of T cell differentiation
C	0045596	biological_process	negative regulation of cell differentiation
C	0045597	biological_process	positive regulation of cell differentiation
C	0045663	biological_process	positive regulation of myoblast differentiation
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0048156	molecular_function	tau protein binding
C	0048870	biological_process	cell motility
C	0050998	molecular_function	nitric-oxide synthase binding
C	0051621	biological_process	regulation of norepinephrine uptake
C	0051623	biological_process	positive regulation of norepinephrine uptake
C	0051726	biological_process	regulation of cell cycle
C	0070062	cellular_component	extracellular exosome
C	0070160	cellular_component	tight junction
C	0070316	biological_process	regulation of G0 to G1 transition
C	0070527	biological_process	platelet aggregation
C	0071896	biological_process	protein localization to adherens junction
C	0072562	cellular_component	blood microparticle
C	0072749	biological_process	cellular response to cytochalasin B
C	0097433	cellular_component	dense body
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098793	cellular_component	presynapse
C	0098871	cellular_component	postsynaptic actin cytoskeleton
C	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
C	0098974	biological_process	postsynaptic actin cytoskeleton organization
C	0098978	cellular_component	glutamatergic synapse
C	0141108	molecular_function	transporter regulator activity
C	0150111	biological_process	regulation of transepithelial transport
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1903076	biological_process	regulation of protein localization to plasma membrane
C	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
C	1990904	cellular_component	ribonucleoprotein complex
C	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
C	2000779	biological_process	regulation of double-strand break repair
C	2000781	biological_process	positive regulation of double-strand break repair
C	2000819	biological_process	regulation of nucleotide-excision repair
D	0000166	molecular_function	nucleotide binding
D	0000776	cellular_component	kinetochore
D	0000785	cellular_component	chromatin
D	0001738	biological_process	morphogenesis of a polarized epithelium
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0005886	cellular_component	plasma membrane
D	0005903	cellular_component	brush border
D	0005911	cellular_component	cell-cell junction
D	0005912	cellular_component	adherens junction
D	0005925	cellular_component	focal adhesion
D	0006338	biological_process	chromatin remodeling
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0007010	biological_process	cytoskeleton organization
D	0007020	biological_process	microtubule nucleation
D	0007163	biological_process	establishment or maintenance of cell polarity
D	0007409	biological_process	axonogenesis
D	0008284	biological_process	positive regulation of cell population proliferation
D	0015629	cellular_component	actin cytoskeleton
D	0016020	cellular_component	membrane
D	0016363	cellular_component	nuclear matrix
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0019894	molecular_function	kinesin binding
D	0019901	molecular_function	protein kinase binding
D	0021762	biological_process	substantia nigra development
D	0030027	cellular_component	lamellipodium
D	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
D	0030235	molecular_function	nitric-oxide synthase regulator activity
D	0030424	cellular_component	axon
D	0030863	cellular_component	cortical cytoskeleton
D	0030957	molecular_function	Tat protein binding
D	0031492	molecular_function	nucleosomal DNA binding
D	0031982	cellular_component	vesicle
D	0032991	cellular_component	protein-containing complex
D	0034333	biological_process	adherens junction assembly
D	0035267	cellular_component	NuA4 histone acetyltransferase complex
D	0035633	biological_process	maintenance of blood-brain barrier
D	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
D	0042802	molecular_function	identical protein binding
D	0042981	biological_process	regulation of apoptotic process
D	0043296	cellular_component	apical junction complex
D	0044305	cellular_component	calyx of Held
D	0045176	biological_process	apical protein localization
D	0045202	cellular_component	synapse
D	0045582	biological_process	positive regulation of T cell differentiation
D	0045596	biological_process	negative regulation of cell differentiation
D	0045597	biological_process	positive regulation of cell differentiation
D	0045663	biological_process	positive regulation of myoblast differentiation
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0048156	molecular_function	tau protein binding
D	0048870	biological_process	cell motility
D	0050998	molecular_function	nitric-oxide synthase binding
D	0051621	biological_process	regulation of norepinephrine uptake
D	0051623	biological_process	positive regulation of norepinephrine uptake
D	0051726	biological_process	regulation of cell cycle
D	0070062	cellular_component	extracellular exosome
D	0070160	cellular_component	tight junction
D	0070316	biological_process	regulation of G0 to G1 transition
D	0070527	biological_process	platelet aggregation
D	0071896	biological_process	protein localization to adherens junction
D	0072562	cellular_component	blood microparticle
D	0072749	biological_process	cellular response to cytochalasin B
D	0097433	cellular_component	dense body
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098793	cellular_component	presynapse
D	0098871	cellular_component	postsynaptic actin cytoskeleton
D	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
D	0098974	biological_process	postsynaptic actin cytoskeleton organization
D	0098978	cellular_component	glutamatergic synapse
D	0141108	molecular_function	transporter regulator activity
D	0150111	biological_process	regulation of transepithelial transport
D	1900242	biological_process	regulation of synaptic vesicle endocytosis
D	1902459	biological_process	positive regulation of stem cell population maintenance
D	1903076	biological_process	regulation of protein localization to plasma membrane
D	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
D	1990904	cellular_component	ribonucleoprotein complex
D	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
D	2000779	biological_process	regulation of double-strand break repair
D	2000781	biological_process	positive regulation of double-strand break repair
D	2000819	biological_process	regulation of nucleotide-excision repair
E	0000166	molecular_function	nucleotide binding
E	0000776	cellular_component	kinetochore
E	0000785	cellular_component	chromatin
E	0001738	biological_process	morphogenesis of a polarized epithelium
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005884	cellular_component	actin filament
E	0005886	cellular_component	plasma membrane
E	0005903	cellular_component	brush border
E	0005911	cellular_component	cell-cell junction
E	0005912	cellular_component	adherens junction
E	0005925	cellular_component	focal adhesion
E	0006338	biological_process	chromatin remodeling
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0007010	biological_process	cytoskeleton organization
E	0007020	biological_process	microtubule nucleation
E	0007163	biological_process	establishment or maintenance of cell polarity
E	0007409	biological_process	axonogenesis
E	0008284	biological_process	positive regulation of cell population proliferation
E	0015629	cellular_component	actin cytoskeleton
E	0016020	cellular_component	membrane
E	0016363	cellular_component	nuclear matrix
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0019894	molecular_function	kinesin binding
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030027	cellular_component	lamellipodium
E	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030424	cellular_component	axon
E	0030863	cellular_component	cortical cytoskeleton
E	0030957	molecular_function	Tat protein binding
E	0031492	molecular_function	nucleosomal DNA binding
E	0031982	cellular_component	vesicle
E	0032991	cellular_component	protein-containing complex
E	0034333	biological_process	adherens junction assembly
E	0035267	cellular_component	NuA4 histone acetyltransferase complex
E	0035633	biological_process	maintenance of blood-brain barrier
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042802	molecular_function	identical protein binding
E	0042981	biological_process	regulation of apoptotic process
E	0043296	cellular_component	apical junction complex
E	0044305	cellular_component	calyx of Held
E	0045176	biological_process	apical protein localization
E	0045202	cellular_component	synapse
E	0045582	biological_process	positive regulation of T cell differentiation
E	0045596	biological_process	negative regulation of cell differentiation
E	0045597	biological_process	positive regulation of cell differentiation
E	0045663	biological_process	positive regulation of myoblast differentiation
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0048156	molecular_function	tau protein binding
E	0048870	biological_process	cell motility
E	0050998	molecular_function	nitric-oxide synthase binding
E	0051621	biological_process	regulation of norepinephrine uptake
E	0051623	biological_process	positive regulation of norepinephrine uptake
E	0051726	biological_process	regulation of cell cycle
E	0070062	cellular_component	extracellular exosome
E	0070160	cellular_component	tight junction
E	0070316	biological_process	regulation of G0 to G1 transition
E	0070527	biological_process	platelet aggregation
E	0071896	biological_process	protein localization to adherens junction
E	0072562	cellular_component	blood microparticle
E	0072749	biological_process	cellular response to cytochalasin B
E	0097433	cellular_component	dense body
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098793	cellular_component	presynapse
E	0098871	cellular_component	postsynaptic actin cytoskeleton
E	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
E	0098974	biological_process	postsynaptic actin cytoskeleton organization
E	0098978	cellular_component	glutamatergic synapse
E	0141108	molecular_function	transporter regulator activity
E	0150111	biological_process	regulation of transepithelial transport
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1902459	biological_process	positive regulation of stem cell population maintenance
E	1903076	biological_process	regulation of protein localization to plasma membrane
E	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
E	1990904	cellular_component	ribonucleoprotein complex
E	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
E	2000779	biological_process	regulation of double-strand break repair
E	2000781	biological_process	positive regulation of double-strand break repair
E	2000819	biological_process	regulation of nucleotide-excision repair
F	0000166	molecular_function	nucleotide binding
F	0000776	cellular_component	kinetochore
F	0000785	cellular_component	chromatin
F	0001738	biological_process	morphogenesis of a polarized epithelium
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005884	cellular_component	actin filament
F	0005886	cellular_component	plasma membrane
F	0005903	cellular_component	brush border
F	0005911	cellular_component	cell-cell junction
F	0005912	cellular_component	adherens junction
F	0005925	cellular_component	focal adhesion
F	0006338	biological_process	chromatin remodeling
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0007010	biological_process	cytoskeleton organization
F	0007020	biological_process	microtubule nucleation
F	0007163	biological_process	establishment or maintenance of cell polarity
F	0007409	biological_process	axonogenesis
F	0008284	biological_process	positive regulation of cell population proliferation
F	0015629	cellular_component	actin cytoskeleton
F	0016020	cellular_component	membrane
F	0016363	cellular_component	nuclear matrix
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0019894	molecular_function	kinesin binding
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0030027	cellular_component	lamellipodium
F	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
F	0030235	molecular_function	nitric-oxide synthase regulator activity
F	0030424	cellular_component	axon
F	0030863	cellular_component	cortical cytoskeleton
F	0030957	molecular_function	Tat protein binding
F	0031492	molecular_function	nucleosomal DNA binding
F	0031982	cellular_component	vesicle
F	0032991	cellular_component	protein-containing complex
F	0034333	biological_process	adherens junction assembly
F	0035267	cellular_component	NuA4 histone acetyltransferase complex
F	0035633	biological_process	maintenance of blood-brain barrier
F	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043296	cellular_component	apical junction complex
F	0044305	cellular_component	calyx of Held
F	0045176	biological_process	apical protein localization
F	0045202	cellular_component	synapse
F	0045582	biological_process	positive regulation of T cell differentiation
F	0045596	biological_process	negative regulation of cell differentiation
F	0045597	biological_process	positive regulation of cell differentiation
F	0045663	biological_process	positive regulation of myoblast differentiation
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0048156	molecular_function	tau protein binding
F	0048870	biological_process	cell motility
F	0050998	molecular_function	nitric-oxide synthase binding
F	0051621	biological_process	regulation of norepinephrine uptake
F	0051623	biological_process	positive regulation of norepinephrine uptake
F	0051726	biological_process	regulation of cell cycle
F	0070062	cellular_component	extracellular exosome
F	0070160	cellular_component	tight junction
F	0070316	biological_process	regulation of G0 to G1 transition
F	0070527	biological_process	platelet aggregation
F	0071896	biological_process	protein localization to adherens junction
F	0072562	cellular_component	blood microparticle
F	0072749	biological_process	cellular response to cytochalasin B
F	0097433	cellular_component	dense body
F	0098685	cellular_component	Schaffer collateral - CA1 synapse
F	0098793	cellular_component	presynapse
F	0098871	cellular_component	postsynaptic actin cytoskeleton
F	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
F	0098974	biological_process	postsynaptic actin cytoskeleton organization
F	0098978	cellular_component	glutamatergic synapse
F	0141108	molecular_function	transporter regulator activity
F	0150111	biological_process	regulation of transepithelial transport
F	1900242	biological_process	regulation of synaptic vesicle endocytosis
F	1902459	biological_process	positive regulation of stem cell population maintenance
F	1903076	biological_process	regulation of protein localization to plasma membrane
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	1990904	cellular_component	ribonucleoprotein complex
F	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
F	2000779	biological_process	regulation of double-strand break repair
F	2000781	biological_process	positive regulation of double-strand break repair
F	2000819	biological_process	regulation of nucleotide-excision repair
G	0000166	molecular_function	nucleotide binding
G	0000776	cellular_component	kinetochore
G	0000785	cellular_component	chromatin
G	0001738	biological_process	morphogenesis of a polarized epithelium
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0005886	cellular_component	plasma membrane
G	0005903	cellular_component	brush border
G	0005911	cellular_component	cell-cell junction
G	0005912	cellular_component	adherens junction
G	0005925	cellular_component	focal adhesion
G	0006338	biological_process	chromatin remodeling
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0007010	biological_process	cytoskeleton organization
G	0007020	biological_process	microtubule nucleation
G	0007163	biological_process	establishment or maintenance of cell polarity
G	0007409	biological_process	axonogenesis
G	0008284	biological_process	positive regulation of cell population proliferation
G	0015629	cellular_component	actin cytoskeleton
G	0016020	cellular_component	membrane
G	0016363	cellular_component	nuclear matrix
G	0016787	molecular_function	hydrolase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0019894	molecular_function	kinesin binding
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0030027	cellular_component	lamellipodium
G	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
G	0030235	molecular_function	nitric-oxide synthase regulator activity
G	0030424	cellular_component	axon
G	0030863	cellular_component	cortical cytoskeleton
G	0030957	molecular_function	Tat protein binding
G	0031492	molecular_function	nucleosomal DNA binding
G	0031982	cellular_component	vesicle
G	0032991	cellular_component	protein-containing complex
G	0034333	biological_process	adherens junction assembly
G	0035267	cellular_component	NuA4 histone acetyltransferase complex
G	0035633	biological_process	maintenance of blood-brain barrier
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042802	molecular_function	identical protein binding
G	0042981	biological_process	regulation of apoptotic process
G	0043296	cellular_component	apical junction complex
G	0044305	cellular_component	calyx of Held
G	0045176	biological_process	apical protein localization
G	0045202	cellular_component	synapse
G	0045582	biological_process	positive regulation of T cell differentiation
G	0045596	biological_process	negative regulation of cell differentiation
G	0045597	biological_process	positive regulation of cell differentiation
G	0045663	biological_process	positive regulation of myoblast differentiation
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0048156	molecular_function	tau protein binding
G	0048870	biological_process	cell motility
G	0050998	molecular_function	nitric-oxide synthase binding
G	0051621	biological_process	regulation of norepinephrine uptake
G	0051623	biological_process	positive regulation of norepinephrine uptake
G	0051726	biological_process	regulation of cell cycle
G	0070062	cellular_component	extracellular exosome
G	0070160	cellular_component	tight junction
G	0070316	biological_process	regulation of G0 to G1 transition
G	0070527	biological_process	platelet aggregation
G	0071896	biological_process	protein localization to adherens junction
G	0072562	cellular_component	blood microparticle
G	0072749	biological_process	cellular response to cytochalasin B
G	0097433	cellular_component	dense body
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098793	cellular_component	presynapse
G	0098871	cellular_component	postsynaptic actin cytoskeleton
G	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
G	0098974	biological_process	postsynaptic actin cytoskeleton organization
G	0098978	cellular_component	glutamatergic synapse
G	0141108	molecular_function	transporter regulator activity
G	0150111	biological_process	regulation of transepithelial transport
G	1900242	biological_process	regulation of synaptic vesicle endocytosis
G	1902459	biological_process	positive regulation of stem cell population maintenance
G	1903076	biological_process	regulation of protein localization to plasma membrane
G	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
G	1990904	cellular_component	ribonucleoprotein complex
G	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
G	2000779	biological_process	regulation of double-strand break repair
G	2000781	biological_process	positive regulation of double-strand break repair
G	2000819	biological_process	regulation of nucleotide-excision repair
H	0000281	biological_process	mitotic cytokinesis
H	0003779	molecular_function	actin binding
H	0005102	molecular_function	signaling receptor binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005911	cellular_component	cell-cell junction
H	0005925	cellular_component	focal adhesion
H	0006606	biological_process	protein import into nucleus
H	0007162	biological_process	negative regulation of cell adhesion
H	0007266	biological_process	Rho protein signal transduction
H	0008154	biological_process	actin polymerization or depolymerization
H	0009615	biological_process	response to virus
H	0010592	biological_process	positive regulation of lamellipodium assembly
H	0010593	biological_process	negative regulation of lamellipodium assembly
H	0014823	biological_process	response to activity
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016363	cellular_component	nuclear matrix
H	0019903	molecular_function	protein phosphatase binding
H	0021766	biological_process	hippocampus development
H	0030027	cellular_component	lamellipodium
H	0030036	biological_process	actin cytoskeleton organization
H	0030042	biological_process	actin filament depolymerization
H	0030043	biological_process	actin filament fragmentation
H	0030175	cellular_component	filopodium
H	0030307	biological_process	positive regulation of cell growth
H	0030424	cellular_component	axon
H	0030426	cellular_component	growth cone
H	0030835	biological_process	negative regulation of actin filament depolymerization
H	0030836	biological_process	positive regulation of actin filament depolymerization
H	0030864	cellular_component	cortical actin cytoskeleton
H	0031252	cellular_component	cell leading edge
H	0031258	cellular_component	lamellipodium membrane
H	0031915	biological_process	positive regulation of synaptic plasticity
H	0031966	cellular_component	mitochondrial membrane
H	0031982	cellular_component	vesicle
H	0032232	biological_process	negative regulation of actin filament bundle assembly
H	0032587	cellular_component	ruffle membrane
H	0040019	biological_process	positive regulation of embryonic development
H	0043025	cellular_component	neuronal cell body
H	0043066	biological_process	negative regulation of apoptotic process
H	0043197	cellular_component	dendritic spine
H	0044794	biological_process	host-mediated activation of viral process
H	0045862	biological_process	positive regulation of proteolysis
H	0050804	biological_process	modulation of chemical synaptic transmission
H	0051014	biological_process	actin filament severing
H	0051015	molecular_function	actin filament binding
H	0051293	biological_process	establishment of spindle localization
H	0051511	biological_process	negative regulation of unidimensional cell growth
H	0051894	biological_process	positive regulation of focal adhesion assembly
H	0060999	biological_process	positive regulation of dendritic spine development
H	0061001	biological_process	regulation of dendritic spine morphogenesis
H	0070062	cellular_component	extracellular exosome
H	0070301	biological_process	cellular response to hydrogen peroxide
H	0071347	biological_process	cellular response to interleukin-1
H	0071354	biological_process	cellular response to interleukin-6
H	0071356	biological_process	cellular response to tumor necrosis factor
H	0071362	biological_process	cellular response to ether
H	0071364	biological_process	cellular response to epidermal growth factor stimulus
H	0090732	cellular_component	cofilin-actin rod
H	0097060	cellular_component	synaptic membrane
H	0098885	biological_process	modification of postsynaptic actin cytoskeleton
H	0098978	cellular_component	glutamatergic synapse
H	0099092	cellular_component	postsynaptic density, intracellular component
H	1902936	molecular_function	phosphatidylinositol bisphosphate binding
H	1902951	biological_process	negative regulation of dendritic spine maintenance
H	1905873	biological_process	positive regulation of protein localization to cell leading edge
H	1905875	biological_process	negative regulation of postsynaptic density organization
H	1990314	biological_process	cellular response to insulin-like growth factor stimulus
H	2000146	biological_process	negative regulation of cell motility
H	2000147	biological_process	positive regulation of cell motility
H	2000784	biological_process	positive regulation of establishment of cell polarity regulating cell shape
H	2000814	biological_process	positive regulation of barbed-end actin filament capping
I	0000281	biological_process	mitotic cytokinesis
I	0003779	molecular_function	actin binding
I	0005102	molecular_function	signaling receptor binding
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005911	cellular_component	cell-cell junction
I	0005925	cellular_component	focal adhesion
I	0006606	biological_process	protein import into nucleus
I	0007162	biological_process	negative regulation of cell adhesion
I	0007266	biological_process	Rho protein signal transduction
I	0008154	biological_process	actin polymerization or depolymerization
I	0009615	biological_process	response to virus
I	0010592	biological_process	positive regulation of lamellipodium assembly
I	0010593	biological_process	negative regulation of lamellipodium assembly
I	0014823	biological_process	response to activity
I	0015629	cellular_component	actin cytoskeleton
I	0016020	cellular_component	membrane
I	0016363	cellular_component	nuclear matrix
I	0019903	molecular_function	protein phosphatase binding
I	0021766	biological_process	hippocampus development
I	0030027	cellular_component	lamellipodium
I	0030036	biological_process	actin cytoskeleton organization
I	0030042	biological_process	actin filament depolymerization
I	0030043	biological_process	actin filament fragmentation
I	0030175	cellular_component	filopodium
I	0030307	biological_process	positive regulation of cell growth
I	0030424	cellular_component	axon
I	0030426	cellular_component	growth cone
I	0030835	biological_process	negative regulation of actin filament depolymerization
I	0030836	biological_process	positive regulation of actin filament depolymerization
I	0030864	cellular_component	cortical actin cytoskeleton
I	0031252	cellular_component	cell leading edge
I	0031258	cellular_component	lamellipodium membrane
I	0031915	biological_process	positive regulation of synaptic plasticity
I	0031966	cellular_component	mitochondrial membrane
I	0031982	cellular_component	vesicle
I	0032232	biological_process	negative regulation of actin filament bundle assembly
I	0032587	cellular_component	ruffle membrane
I	0040019	biological_process	positive regulation of embryonic development
I	0043025	cellular_component	neuronal cell body
I	0043066	biological_process	negative regulation of apoptotic process
I	0043197	cellular_component	dendritic spine
I	0044794	biological_process	host-mediated activation of viral process
I	0045862	biological_process	positive regulation of proteolysis
I	0050804	biological_process	modulation of chemical synaptic transmission
I	0051014	biological_process	actin filament severing
I	0051015	molecular_function	actin filament binding
I	0051293	biological_process	establishment of spindle localization
I	0051511	biological_process	negative regulation of unidimensional cell growth
I	0051894	biological_process	positive regulation of focal adhesion assembly
I	0060999	biological_process	positive regulation of dendritic spine development
I	0061001	biological_process	regulation of dendritic spine morphogenesis
I	0070062	cellular_component	extracellular exosome
I	0070301	biological_process	cellular response to hydrogen peroxide
I	0071347	biological_process	cellular response to interleukin-1
I	0071354	biological_process	cellular response to interleukin-6
I	0071356	biological_process	cellular response to tumor necrosis factor
I	0071362	biological_process	cellular response to ether
I	0071364	biological_process	cellular response to epidermal growth factor stimulus
I	0090732	cellular_component	cofilin-actin rod
I	0097060	cellular_component	synaptic membrane
I	0098885	biological_process	modification of postsynaptic actin cytoskeleton
I	0098978	cellular_component	glutamatergic synapse
I	0099092	cellular_component	postsynaptic density, intracellular component
I	1902936	molecular_function	phosphatidylinositol bisphosphate binding
I	1902951	biological_process	negative regulation of dendritic spine maintenance
I	1905873	biological_process	positive regulation of protein localization to cell leading edge
I	1905875	biological_process	negative regulation of postsynaptic density organization
I	1990314	biological_process	cellular response to insulin-like growth factor stimulus
I	2000146	biological_process	negative regulation of cell motility
I	2000147	biological_process	positive regulation of cell motility
I	2000784	biological_process	positive regulation of establishment of cell polarity regulating cell shape
I	2000814	biological_process	positive regulation of barbed-end actin filament capping
J	0000281	biological_process	mitotic cytokinesis
J	0003779	molecular_function	actin binding
J	0005102	molecular_function	signaling receptor binding
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005911	cellular_component	cell-cell junction
J	0005925	cellular_component	focal adhesion
J	0006606	biological_process	protein import into nucleus
J	0007162	biological_process	negative regulation of cell adhesion
J	0007266	biological_process	Rho protein signal transduction
J	0008154	biological_process	actin polymerization or depolymerization
J	0009615	biological_process	response to virus
J	0010592	biological_process	positive regulation of lamellipodium assembly
J	0010593	biological_process	negative regulation of lamellipodium assembly
J	0014823	biological_process	response to activity
J	0015629	cellular_component	actin cytoskeleton
J	0016020	cellular_component	membrane
J	0016363	cellular_component	nuclear matrix
J	0019903	molecular_function	protein phosphatase binding
J	0021766	biological_process	hippocampus development
J	0030027	cellular_component	lamellipodium
J	0030036	biological_process	actin cytoskeleton organization
J	0030042	biological_process	actin filament depolymerization
J	0030043	biological_process	actin filament fragmentation
J	0030175	cellular_component	filopodium
J	0030307	biological_process	positive regulation of cell growth
J	0030424	cellular_component	axon
J	0030426	cellular_component	growth cone
J	0030835	biological_process	negative regulation of actin filament depolymerization
J	0030836	biological_process	positive regulation of actin filament depolymerization
J	0030864	cellular_component	cortical actin cytoskeleton
J	0031252	cellular_component	cell leading edge
J	0031258	cellular_component	lamellipodium membrane
J	0031915	biological_process	positive regulation of synaptic plasticity
J	0031966	cellular_component	mitochondrial membrane
J	0031982	cellular_component	vesicle
J	0032232	biological_process	negative regulation of actin filament bundle assembly
J	0032587	cellular_component	ruffle membrane
J	0040019	biological_process	positive regulation of embryonic development
J	0043025	cellular_component	neuronal cell body
J	0043066	biological_process	negative regulation of apoptotic process
J	0043197	cellular_component	dendritic spine
J	0044794	biological_process	host-mediated activation of viral process
J	0045862	biological_process	positive regulation of proteolysis
J	0050804	biological_process	modulation of chemical synaptic transmission
J	0051014	biological_process	actin filament severing
J	0051015	molecular_function	actin filament binding
J	0051293	biological_process	establishment of spindle localization
J	0051511	biological_process	negative regulation of unidimensional cell growth
J	0051894	biological_process	positive regulation of focal adhesion assembly
J	0060999	biological_process	positive regulation of dendritic spine development
J	0061001	biological_process	regulation of dendritic spine morphogenesis
J	0070062	cellular_component	extracellular exosome
J	0070301	biological_process	cellular response to hydrogen peroxide
J	0071347	biological_process	cellular response to interleukin-1
J	0071354	biological_process	cellular response to interleukin-6
J	0071356	biological_process	cellular response to tumor necrosis factor
J	0071362	biological_process	cellular response to ether
J	0071364	biological_process	cellular response to epidermal growth factor stimulus
J	0090732	cellular_component	cofilin-actin rod
J	0097060	cellular_component	synaptic membrane
J	0098885	biological_process	modification of postsynaptic actin cytoskeleton
J	0098978	cellular_component	glutamatergic synapse
J	0099092	cellular_component	postsynaptic density, intracellular component
J	1902936	molecular_function	phosphatidylinositol bisphosphate binding
J	1902951	biological_process	negative regulation of dendritic spine maintenance
J	1905873	biological_process	positive regulation of protein localization to cell leading edge
J	1905875	biological_process	negative regulation of postsynaptic density organization
J	1990314	biological_process	cellular response to insulin-like growth factor stimulus
J	2000146	biological_process	negative regulation of cell motility
J	2000147	biological_process	positive regulation of cell motility
J	2000784	biological_process	positive regulation of establishment of cell polarity regulating cell shape
J	2000814	biological_process	positive regulation of barbed-end actin filament capping
K	0000281	biological_process	mitotic cytokinesis
K	0003779	molecular_function	actin binding
K	0005102	molecular_function	signaling receptor binding
K	0005515	molecular_function	protein binding
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005911	cellular_component	cell-cell junction
K	0005925	cellular_component	focal adhesion
K	0006606	biological_process	protein import into nucleus
K	0007162	biological_process	negative regulation of cell adhesion
K	0007266	biological_process	Rho protein signal transduction
K	0008154	biological_process	actin polymerization or depolymerization
K	0009615	biological_process	response to virus
K	0010592	biological_process	positive regulation of lamellipodium assembly
K	0010593	biological_process	negative regulation of lamellipodium assembly
K	0014823	biological_process	response to activity
K	0015629	cellular_component	actin cytoskeleton
K	0016020	cellular_component	membrane
K	0016363	cellular_component	nuclear matrix
K	0019903	molecular_function	protein phosphatase binding
K	0021766	biological_process	hippocampus development
K	0030027	cellular_component	lamellipodium
K	0030036	biological_process	actin cytoskeleton organization
K	0030042	biological_process	actin filament depolymerization
K	0030043	biological_process	actin filament fragmentation
K	0030175	cellular_component	filopodium
K	0030307	biological_process	positive regulation of cell growth
K	0030424	cellular_component	axon
K	0030426	cellular_component	growth cone
K	0030835	biological_process	negative regulation of actin filament depolymerization
K	0030836	biological_process	positive regulation of actin filament depolymerization
K	0030864	cellular_component	cortical actin cytoskeleton
K	0031252	cellular_component	cell leading edge
K	0031258	cellular_component	lamellipodium membrane
K	0031915	biological_process	positive regulation of synaptic plasticity
K	0031966	cellular_component	mitochondrial membrane
K	0031982	cellular_component	vesicle
K	0032232	biological_process	negative regulation of actin filament bundle assembly
K	0032587	cellular_component	ruffle membrane
K	0040019	biological_process	positive regulation of embryonic development
K	0043025	cellular_component	neuronal cell body
K	0043066	biological_process	negative regulation of apoptotic process
K	0043197	cellular_component	dendritic spine
K	0044794	biological_process	host-mediated activation of viral process
K	0045862	biological_process	positive regulation of proteolysis
K	0050804	biological_process	modulation of chemical synaptic transmission
K	0051014	biological_process	actin filament severing
K	0051015	molecular_function	actin filament binding
K	0051293	biological_process	establishment of spindle localization
K	0051511	biological_process	negative regulation of unidimensional cell growth
K	0051894	biological_process	positive regulation of focal adhesion assembly
K	0060999	biological_process	positive regulation of dendritic spine development
K	0061001	biological_process	regulation of dendritic spine morphogenesis
K	0070062	cellular_component	extracellular exosome
K	0070301	biological_process	cellular response to hydrogen peroxide
K	0071347	biological_process	cellular response to interleukin-1
K	0071354	biological_process	cellular response to interleukin-6
K	0071356	biological_process	cellular response to tumor necrosis factor
K	0071362	biological_process	cellular response to ether
K	0071364	biological_process	cellular response to epidermal growth factor stimulus
K	0090732	cellular_component	cofilin-actin rod
K	0097060	cellular_component	synaptic membrane
K	0098885	biological_process	modification of postsynaptic actin cytoskeleton
K	0098978	cellular_component	glutamatergic synapse
K	0099092	cellular_component	postsynaptic density, intracellular component
K	1902936	molecular_function	phosphatidylinositol bisphosphate binding
K	1902951	biological_process	negative regulation of dendritic spine maintenance
K	1905873	biological_process	positive regulation of protein localization to cell leading edge
K	1905875	biological_process	negative regulation of postsynaptic density organization
K	1990314	biological_process	cellular response to insulin-like growth factor stimulus
K	2000146	biological_process	negative regulation of cell motility
K	2000147	biological_process	positive regulation of cell motility
K	2000784	biological_process	positive regulation of establishment of cell polarity regulating cell shape
K	2000814	biological_process	positive regulation of barbed-end actin filament capping
L	0001725	cellular_component	stress fiber
L	0003779	molecular_function	actin binding
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005884	cellular_component	actin filament
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0007015	biological_process	actin filament organization
L	0016477	biological_process	cell migration
L	0030027	cellular_component	lamellipodium
L	0030036	biological_process	actin cytoskeleton organization
L	0031252	cellular_component	cell leading edge
L	0031529	biological_process	ruffle organization
L	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
L	0034316	biological_process	negative regulation of Arp2/3 complex-mediated actin nucleation
L	0035767	biological_process	endothelial cell chemotaxis
L	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
L	0042060	biological_process	wound healing
L	0042802	molecular_function	identical protein binding
L	0045202	cellular_component	synapse
L	0045296	molecular_function	cadherin binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051015	molecular_function	actin filament binding
L	0051017	biological_process	actin filament bundle assembly
L	0051129	biological_process	negative regulation of cellular component organization
L	0070062	cellular_component	extracellular exosome
L	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
L	0071933	molecular_function	Arp2/3 complex binding
L	0071944	cellular_component	cell periphery
L	0090135	biological_process	actin filament branching
L	0098978	cellular_component	glutamatergic synapse
L	1902463	biological_process	protein localization to cell leading edge
L	2000394	biological_process	positive regulation of lamellipodium morphogenesis
M	0001725	cellular_component	stress fiber
M	0003779	molecular_function	actin binding
M	0005515	molecular_function	protein binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005884	cellular_component	actin filament
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0007015	biological_process	actin filament organization
M	0016477	biological_process	cell migration
M	0030027	cellular_component	lamellipodium
M	0030036	biological_process	actin cytoskeleton organization
M	0031252	cellular_component	cell leading edge
M	0031529	biological_process	ruffle organization
M	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
M	0034316	biological_process	negative regulation of Arp2/3 complex-mediated actin nucleation
M	0035767	biological_process	endothelial cell chemotaxis
M	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
M	0042060	biological_process	wound healing
M	0042802	molecular_function	identical protein binding
M	0045202	cellular_component	synapse
M	0045296	molecular_function	cadherin binding
M	0048471	cellular_component	perinuclear region of cytoplasm
M	0051015	molecular_function	actin filament binding
M	0051017	biological_process	actin filament bundle assembly
M	0051129	biological_process	negative regulation of cellular component organization
M	0070062	cellular_component	extracellular exosome
M	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
M	0071933	molecular_function	Arp2/3 complex binding
M	0071944	cellular_component	cell periphery
M	0090135	biological_process	actin filament branching
M	0098978	cellular_component	glutamatergic synapse
M	1902463	biological_process	protein localization to cell leading edge
M	2000394	biological_process	positive regulation of lamellipodium morphogenesis
N	0001725	cellular_component	stress fiber
N	0003779	molecular_function	actin binding
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005884	cellular_component	actin filament
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0007015	biological_process	actin filament organization
N	0016477	biological_process	cell migration
N	0030027	cellular_component	lamellipodium
N	0030036	biological_process	actin cytoskeleton organization
N	0031252	cellular_component	cell leading edge
N	0031529	biological_process	ruffle organization
N	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
N	0034316	biological_process	negative regulation of Arp2/3 complex-mediated actin nucleation
N	0035767	biological_process	endothelial cell chemotaxis
N	0036120	biological_process	cellular response to platelet-derived growth factor stimulus
N	0042060	biological_process	wound healing
N	0042802	molecular_function	identical protein binding
N	0045202	cellular_component	synapse
N	0045296	molecular_function	cadherin binding
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0051015	molecular_function	actin filament binding
N	0051017	biological_process	actin filament bundle assembly
N	0051129	biological_process	negative regulation of cellular component organization
N	0070062	cellular_component	extracellular exosome
N	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
N	0071933	molecular_function	Arp2/3 complex binding
N	0071944	cellular_component	cell periphery
N	0090135	biological_process	actin filament branching
N	0098978	cellular_component	glutamatergic synapse
N	1902463	biological_process	protein localization to cell leading edge
N	2000394	biological_process	positive regulation of lamellipodium morphogenesis

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
L	ILE644-VAL650

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GLHEIKLLGKG

Chain	Residue	Details
L	GLY528-GLY538

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAgcDnVVLIWNV

Chain	Residue	Details
L	LEU148-VAL162

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"PubMed","id":"29343822","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Cross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Lys-Glu) (interchain with E-270); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	596
Details	Domain: {"description":"ADF-H","evidences":[{"source":"PROSITE-ProRule","id":"PRU00599","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2005","submissionDatabase":"UniProtKB","authors":["Quadroni M.","Bienvenut W.V."]}},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by NRK","evidences":[{"source":"PubMed","id":"12837278","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P18760","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"30550596","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	162
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	147
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	129
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	129
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	135
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	117
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---