9Q29

DX2-CX3 structure capping RAD51 filament

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000400	molecular_function	four-way junction DNA binding
C	0000707	biological_process	meiotic DNA recombinase assembly
C	0000722	biological_process	telomere maintenance via recombination
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0007062	biological_process	sister chromatid cohesion
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0031297	biological_process	replication fork processing
C	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
C	0033065	cellular_component	Rad51C-XRCC3 complex
C	0043596	cellular_component	nuclear replication fork
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0097435	biological_process	supramolecular fiber organization
D	0000400	molecular_function	four-way junction DNA binding
D	0000722	biological_process	telomere maintenance via recombination
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005657	cellular_component	replication fork
D	0005813	cellular_component	centrosome
D	0005815	cellular_component	microtubule organizing center
D	0006281	biological_process	DNA repair
D	0007131	biological_process	reciprocal meiotic recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
D	0042148	biological_process	DNA strand invasion
D	0043015	molecular_function	gamma-tubulin binding
D	0097435	biological_process	supramolecular fiber organization
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
G	0000150	molecular_function	DNA strand exchange activity
G	0000152	cellular_component	nuclear ubiquitin ligase complex
G	0000228	cellular_component	nuclear chromosome
G	0000722	biological_process	telomere maintenance via recombination
G	0000724	biological_process	double-strand break repair via homologous recombination
G	0000730	biological_process	DNA recombinase assembly
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0000793	cellular_component	condensed chromosome
G	0000794	cellular_component	condensed nuclear chromosome
G	0000800	cellular_component	lateral element
G	0003682	molecular_function	chromatin binding
G	0003690	molecular_function	double-stranded DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006281	biological_process	DNA repair
G	0006310	biological_process	DNA recombination
G	0006312	biological_process	mitotic recombination
G	0006974	biological_process	DNA damage response
G	0007127	biological_process	meiosis I
G	0007131	biological_process	reciprocal meiotic recombination
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0009410	biological_process	response to xenobiotic stimulus
G	0009636	biological_process	response to toxic substance
G	0010165	biological_process	response to X-ray
G	0010569	biological_process	regulation of double-strand break repair via homologous recombination
G	0010833	biological_process	telomere maintenance via telomere lengthening
G	0016605	cellular_component	PML body
G	0016887	molecular_function	ATP hydrolysis activity
G	0019899	molecular_function	enzyme binding
G	0031297	biological_process	replication fork processing
G	0031491	molecular_function	nucleosome binding
G	0032991	cellular_component	protein-containing complex
G	0032993	cellular_component	protein-DNA complex
G	0035861	cellular_component	site of double-strand break
G	0036297	biological_process	interstrand cross-link repair
G	0042148	biological_process	DNA strand invasion
G	0042802	molecular_function	identical protein binding
G	0048471	cellular_component	perinuclear region of cytoplasm
G	0051321	biological_process	meiotic cell cycle
G	0070182	molecular_function	DNA polymerase binding
G	0070192	biological_process	chromosome organization involved in meiotic cell cycle
G	0071479	biological_process	cellular response to ionizing radiation
G	0071480	biological_process	cellular response to gamma radiation
G	0072719	biological_process	cellular response to cisplatin
G	0072757	biological_process	cellular response to camptothecin
G	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
G	1904631	biological_process	response to glucoside
G	1990918	biological_process	double-strand break repair involved in meiotic recombination
G	2000001	biological_process	regulation of DNA damage checkpoint
I	0000150	molecular_function	DNA strand exchange activity
I	0000152	cellular_component	nuclear ubiquitin ligase complex
I	0000228	cellular_component	nuclear chromosome
I	0000722	biological_process	telomere maintenance via recombination
I	0000724	biological_process	double-strand break repair via homologous recombination
I	0000730	biological_process	DNA recombinase assembly
I	0000781	cellular_component	chromosome, telomeric region
I	0000785	cellular_component	chromatin
I	0000793	cellular_component	condensed chromosome
I	0000794	cellular_component	condensed nuclear chromosome
I	0000800	cellular_component	lateral element
I	0003682	molecular_function	chromatin binding
I	0003690	molecular_function	double-stranded DNA binding
I	0003697	molecular_function	single-stranded DNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006310	biological_process	DNA recombination
I	0006312	biological_process	mitotic recombination
I	0006974	biological_process	DNA damage response
I	0007127	biological_process	meiosis I
I	0007131	biological_process	reciprocal meiotic recombination
I	0008094	molecular_function	ATP-dependent activity, acting on DNA
I	0009410	biological_process	response to xenobiotic stimulus
I	0009636	biological_process	response to toxic substance
I	0010165	biological_process	response to X-ray
I	0010569	biological_process	regulation of double-strand break repair via homologous recombination
I	0010833	biological_process	telomere maintenance via telomere lengthening
I	0016605	cellular_component	PML body
I	0016887	molecular_function	ATP hydrolysis activity
I	0019899	molecular_function	enzyme binding
I	0031297	biological_process	replication fork processing
I	0031491	molecular_function	nucleosome binding
I	0032991	cellular_component	protein-containing complex
I	0032993	cellular_component	protein-DNA complex
I	0035861	cellular_component	site of double-strand break
I	0036297	biological_process	interstrand cross-link repair
I	0042148	biological_process	DNA strand invasion
I	0042802	molecular_function	identical protein binding
I	0048471	cellular_component	perinuclear region of cytoplasm
I	0051321	biological_process	meiotic cell cycle
I	0070182	molecular_function	DNA polymerase binding
I	0070192	biological_process	chromosome organization involved in meiotic cell cycle
I	0071479	biological_process	cellular response to ionizing radiation
I	0071480	biological_process	cellular response to gamma radiation
I	0072719	biological_process	cellular response to cisplatin
I	0072757	biological_process	cellular response to camptothecin
I	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
I	1904631	biological_process	response to glucoside
I	1990918	biological_process	double-strand break repair involved in meiotic recombination
I	2000001	biological_process	regulation of DNA damage checkpoint
J	0000150	molecular_function	DNA strand exchange activity
J	0000152	cellular_component	nuclear ubiquitin ligase complex
J	0000228	cellular_component	nuclear chromosome
J	0000722	biological_process	telomere maintenance via recombination
J	0000724	biological_process	double-strand break repair via homologous recombination
J	0000730	biological_process	DNA recombinase assembly
J	0000781	cellular_component	chromosome, telomeric region
J	0000785	cellular_component	chromatin
J	0000793	cellular_component	condensed chromosome
J	0000794	cellular_component	condensed nuclear chromosome
J	0000800	cellular_component	lateral element
J	0003682	molecular_function	chromatin binding
J	0003690	molecular_function	double-stranded DNA binding
J	0003697	molecular_function	single-stranded DNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005730	cellular_component	nucleolus
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0006281	biological_process	DNA repair
J	0006310	biological_process	DNA recombination
J	0006312	biological_process	mitotic recombination
J	0006974	biological_process	DNA damage response
J	0007127	biological_process	meiosis I
J	0007131	biological_process	reciprocal meiotic recombination
J	0008094	molecular_function	ATP-dependent activity, acting on DNA
J	0009410	biological_process	response to xenobiotic stimulus
J	0009636	biological_process	response to toxic substance
J	0010165	biological_process	response to X-ray
J	0010569	biological_process	regulation of double-strand break repair via homologous recombination
J	0010833	biological_process	telomere maintenance via telomere lengthening
J	0016605	cellular_component	PML body
J	0016887	molecular_function	ATP hydrolysis activity
J	0019899	molecular_function	enzyme binding
J	0031297	biological_process	replication fork processing
J	0031491	molecular_function	nucleosome binding
J	0032991	cellular_component	protein-containing complex
J	0032993	cellular_component	protein-DNA complex
J	0035861	cellular_component	site of double-strand break
J	0036297	biological_process	interstrand cross-link repair
J	0042148	biological_process	DNA strand invasion
J	0042802	molecular_function	identical protein binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0051321	biological_process	meiotic cell cycle
J	0070182	molecular_function	DNA polymerase binding
J	0070192	biological_process	chromosome organization involved in meiotic cell cycle
J	0071479	biological_process	cellular response to ionizing radiation
J	0071480	biological_process	cellular response to gamma radiation
J	0072719	biological_process	cellular response to cisplatin
J	0072757	biological_process	cellular response to camptothecin
J	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
J	1904631	biological_process	response to glucoside
J	1990918	biological_process	double-strand break repair involved in meiotic recombination
J	2000001	biological_process	regulation of DNA damage checkpoint
K	0000150	molecular_function	DNA strand exchange activity
K	0000152	cellular_component	nuclear ubiquitin ligase complex
K	0000228	cellular_component	nuclear chromosome
K	0000722	biological_process	telomere maintenance via recombination
K	0000724	biological_process	double-strand break repair via homologous recombination
K	0000730	biological_process	DNA recombinase assembly
K	0000781	cellular_component	chromosome, telomeric region
K	0000785	cellular_component	chromatin
K	0000793	cellular_component	condensed chromosome
K	0000794	cellular_component	condensed nuclear chromosome
K	0000800	cellular_component	lateral element
K	0003682	molecular_function	chromatin binding
K	0003690	molecular_function	double-stranded DNA binding
K	0003697	molecular_function	single-stranded DNA binding
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005694	cellular_component	chromosome
K	0005730	cellular_component	nucleolus
K	0005737	cellular_component	cytoplasm
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0005813	cellular_component	centrosome
K	0005829	cellular_component	cytosol
K	0006281	biological_process	DNA repair
K	0006310	biological_process	DNA recombination
K	0006312	biological_process	mitotic recombination
K	0006974	biological_process	DNA damage response
K	0007127	biological_process	meiosis I
K	0007131	biological_process	reciprocal meiotic recombination
K	0008094	molecular_function	ATP-dependent activity, acting on DNA
K	0009410	biological_process	response to xenobiotic stimulus
K	0009636	biological_process	response to toxic substance
K	0010165	biological_process	response to X-ray
K	0010569	biological_process	regulation of double-strand break repair via homologous recombination
K	0010833	biological_process	telomere maintenance via telomere lengthening
K	0016605	cellular_component	PML body
K	0016887	molecular_function	ATP hydrolysis activity
K	0019899	molecular_function	enzyme binding
K	0031297	biological_process	replication fork processing
K	0031491	molecular_function	nucleosome binding
K	0032991	cellular_component	protein-containing complex
K	0032993	cellular_component	protein-DNA complex
K	0035861	cellular_component	site of double-strand break
K	0036297	biological_process	interstrand cross-link repair
K	0042148	biological_process	DNA strand invasion
K	0042802	molecular_function	identical protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0051321	biological_process	meiotic cell cycle
K	0070182	molecular_function	DNA polymerase binding
K	0070192	biological_process	chromosome organization involved in meiotic cell cycle
K	0071479	biological_process	cellular response to ionizing radiation
K	0071480	biological_process	cellular response to gamma radiation
K	0072719	biological_process	cellular response to cisplatin
K	0072757	biological_process	cellular response to camptothecin
K	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
K	1904631	biological_process	response to glucoside
K	1990918	biological_process	double-strand break repair involved in meiotic recombination
K	2000001	biological_process	regulation of DNA damage checkpoint
L	0000150	molecular_function	DNA strand exchange activity
L	0000152	cellular_component	nuclear ubiquitin ligase complex
L	0000228	cellular_component	nuclear chromosome
L	0000722	biological_process	telomere maintenance via recombination
L	0000724	biological_process	double-strand break repair via homologous recombination
L	0000730	biological_process	DNA recombinase assembly
L	0000781	cellular_component	chromosome, telomeric region
L	0000785	cellular_component	chromatin
L	0000793	cellular_component	condensed chromosome
L	0000794	cellular_component	condensed nuclear chromosome
L	0000800	cellular_component	lateral element
L	0003682	molecular_function	chromatin binding
L	0003690	molecular_function	double-stranded DNA binding
L	0003697	molecular_function	single-stranded DNA binding
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005694	cellular_component	chromosome
L	0005730	cellular_component	nucleolus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0005813	cellular_component	centrosome
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006310	biological_process	DNA recombination
L	0006312	biological_process	mitotic recombination
L	0006974	biological_process	DNA damage response
L	0007127	biological_process	meiosis I
L	0007131	biological_process	reciprocal meiotic recombination
L	0008094	molecular_function	ATP-dependent activity, acting on DNA
L	0009410	biological_process	response to xenobiotic stimulus
L	0009636	biological_process	response to toxic substance
L	0010165	biological_process	response to X-ray
L	0010569	biological_process	regulation of double-strand break repair via homologous recombination
L	0010833	biological_process	telomere maintenance via telomere lengthening
L	0016605	cellular_component	PML body
L	0016887	molecular_function	ATP hydrolysis activity
L	0019899	molecular_function	enzyme binding
L	0031297	biological_process	replication fork processing
L	0031491	molecular_function	nucleosome binding
L	0032991	cellular_component	protein-containing complex
L	0032993	cellular_component	protein-DNA complex
L	0035861	cellular_component	site of double-strand break
L	0036297	biological_process	interstrand cross-link repair
L	0042148	biological_process	DNA strand invasion
L	0042802	molecular_function	identical protein binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0051321	biological_process	meiotic cell cycle
L	0070182	molecular_function	DNA polymerase binding
L	0070192	biological_process	chromosome organization involved in meiotic cell cycle
L	0071479	biological_process	cellular response to ionizing radiation
L	0071480	biological_process	cellular response to gamma radiation
L	0072719	biological_process	cellular response to cisplatin
L	0072757	biological_process	cellular response to camptothecin
L	0099182	cellular_component	presynaptic intermediate filament cytoskeleton
L	1904631	biological_process	response to glucoside
L	1990918	biological_process	double-strand break repair involved in meiotic recombination
L	2000001	biological_process	regulation of DNA damage checkpoint
R	0000400	molecular_function	four-way junction DNA binding
R	0000722	biological_process	telomere maintenance via recombination
R	0000724	biological_process	double-strand break repair via homologous recombination
R	0000781	cellular_component	chromosome, telomeric region
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005657	cellular_component	replication fork
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0006281	biological_process	DNA repair
R	0006310	biological_process	DNA recombination
R	0006974	biological_process	DNA damage response
R	0008821	molecular_function	crossover junction DNA endonuclease activity
R	0010824	biological_process	regulation of centrosome duplication
R	0031297	biological_process	replication fork processing
R	0033065	cellular_component	Rad51C-XRCC3 complex
R	0036297	biological_process	interstrand cross-link repair
R	0043596	cellular_component	nuclear replication fork
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0071140	biological_process	resolution of mitotic recombination intermediates
R	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
R	0090656	biological_process	t-circle formation
R	0090657	biological_process	telomeric loop disassembly
R	0090737	biological_process	telomere maintenance via telomere trimming
X	0000278	biological_process	mitotic cell cycle
X	0000400	molecular_function	four-way junction DNA binding
X	0000724	biological_process	double-strand break repair via homologous recombination
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005657	cellular_component	replication fork
X	0005813	cellular_component	centrosome
X	0006281	biological_process	DNA repair
X	0007098	biological_process	centrosome cycle
X	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
X	0042148	biological_process	DNA strand invasion
X	0051321	biological_process	meiotic cell cycle
X	0097435	biological_process	supramolecular fiber organization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	145
Details	Domain: {"description":"HhH"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	365
Details	Region: {"description":"Interaction with PALB2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	75
Details	Motif: {"description":"Nuclear export signal; masked by the interaction with BRCA2","evidences":[{"source":"PubMed","id":"24013206","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	50
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29507080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NWL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	5
Details	Modified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"9461559","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CHEK1","evidences":[{"source":"PubMed","id":"15665856","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	15
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23393192","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---