9Q19
Class III (T1D0) of Human telomerase catalytic core with shelterin protein TPP1, BIBR1532, dGpNHpp and DNA primer ending in TTAG
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000333 | cellular_component | telomerase catalytic core complex |
| A | 0000722 | biological_process | telomere maintenance via recombination |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0000783 | cellular_component | nuclear telomere cap complex |
| A | 0001172 | biological_process | RNA-templated transcription |
| A | 0001223 | molecular_function | transcription coactivator binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003720 | molecular_function | telomerase activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0003968 | molecular_function | RNA-directed RNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005697 | cellular_component | telomerase holoenzyme complex |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0007004 | biological_process | telomere maintenance via telomerase |
| A | 0007005 | biological_process | mitochondrion organization |
| A | 0007507 | biological_process | heart development |
| A | 0016605 | cellular_component | PML body |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0022616 | biological_process | DNA strand elongation |
| A | 0030177 | biological_process | positive regulation of Wnt signaling pathway |
| A | 0030422 | biological_process | siRNA processing |
| A | 0031379 | cellular_component | RNA-directed RNA polymerase complex |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0034061 | molecular_function | DNA polymerase activity |
| A | 0042162 | molecular_function | telomeric repeat DNA binding |
| A | 0042635 | biological_process | positive regulation of hair cycle |
| A | 0042645 | cellular_component | mitochondrial nucleoid |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0043524 | biological_process | negative regulation of neuron apoptotic process |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046686 | biological_process | response to cadmium ion |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0070034 | molecular_function | telomerase RNA binding |
| A | 0070200 | biological_process | establishment of protein localization to telomere |
| A | 0071456 | biological_process | cellular response to hypoxia |
| A | 0071897 | biological_process | DNA biosynthetic process |
| A | 0090399 | biological_process | replicative senescence |
| A | 0098680 | molecular_function | template-free RNA nucleotidyltransferase activity |
| A | 0140745 | biological_process | siRNA transcription |
| A | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| A | 1902895 | biological_process | positive regulation of miRNA transcription |
| A | 1903620 | biological_process | positive regulation of transdifferentiation |
| A | 1904707 | biological_process | positive regulation of vascular associated smooth muscle cell proliferation |
| A | 1904751 | biological_process | positive regulation of protein localization to nucleolus |
| A | 1904754 | biological_process | positive regulation of vascular associated smooth muscle cell migration |
| A | 1990572 | cellular_component | TERT-RMRP complex |
| A | 2000352 | biological_process | negative regulation of endothelial cell apoptotic process |
| A | 2000648 | biological_process | positive regulation of stem cell proliferation |
| A | 2000773 | biological_process | negative regulation of cellular senescence |
| A | 2001240 | biological_process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| F | 0000786 | cellular_component | nucleosome |
| F | 0002227 | biological_process | innate immune response in mucosa |
| F | 0003677 | molecular_function | DNA binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0005694 | cellular_component | chromosome |
| F | 0006325 | biological_process | chromatin organization |
| F | 0006334 | biological_process | nucleosome assembly |
| F | 0019731 | biological_process | antibacterial humoral response |
| F | 0030527 | molecular_function | structural constituent of chromatin |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0050830 | biological_process | defense response to Gram-positive bacterium |
| F | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| F | 0070062 | cellular_component | extracellular exosome |
| G | 0000786 | cellular_component | nucleosome |
| G | 0005634 | cellular_component | nucleus |
| G | 0005694 | cellular_component | chromosome |
| G | 0030527 | molecular_function | structural constituent of chromatin |
| G | 0031507 | biological_process | heterochromatin formation |
| G | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Required for regulating specificity for telomeric DNA and for processivity for primer elongation"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Region: {"description":"Required for oligomerization"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Primer grip sequence"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 196 |
| Details | Region: {"description":"CTE"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Motif: {"description":"TFLY; involved in RNA binding","evidences":[{"source":"UniProtKB","id":"Q4KTA7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for optimal binding of telomeric ssDNA and incorporation of nucleotides at the second position of the template"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for nucleotide incorporation and primer extension rate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by DYRK2","evidences":[{"source":"PubMed","id":"23362280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC-type Tyr-kinases","evidences":[{"source":"PubMed","id":"12808100","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18829466","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Motif: {"description":"PWI"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"UniProtKB","id":"Q64475","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"UniProtKB","id":"Q6ZWY9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-lactoyllysine; alternate","evidences":[{"source":"PubMed","id":"31645732","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-isonicotinyllysine; alternate","evidences":[{"source":"PubMed","id":"34545082","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Dimethylated arginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"PubMed","id":"34961760","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q96A08","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q00729","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"PubMed","id":"22389435","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"16307923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16627869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16713563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22121020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
