9PVY

Cryo-EM structure of cardiac amyloid fibril from a variant apolipoprotein A-I L90P amyloidosis patient

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding
A	0002719	biological_process	negative regulation of cytokine production involved in immune response
A	0005102	molecular_function	signaling receptor binding
A	0005319	molecular_function	lipid carrier activity
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005769	cellular_component	early endosome
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006656	biological_process	phosphatidylcholine biosynthetic process
A	0007179	biological_process	transforming growth factor beta receptor signaling pathway
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007229	biological_process	integrin-mediated signaling pathway
A	0008035	molecular_function	high-density lipoprotein particle binding
A	0008203	biological_process	cholesterol metabolic process
A	0008289	molecular_function	lipid binding
A	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
A	0010875	biological_process	positive regulation of cholesterol efflux
A	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
A	0015485	molecular_function	cholesterol binding
A	0018158	biological_process	protein oxidation
A	0018206	biological_process	peptidyl-methionine modification
A	0019899	molecular_function	enzyme binding
A	0030139	cellular_component	endocytic vesicle
A	0030301	biological_process	cholesterol transport
A	0031072	molecular_function	heat shock protein binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0032489	biological_process	regulation of Cdc42 protein signal transduction
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0033344	biological_process	cholesterol efflux
A	0033700	biological_process	phospholipid efflux
A	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
A	0034190	molecular_function	apolipoprotein receptor binding
A	0034191	molecular_function	apolipoprotein A-I receptor binding
A	0034205	biological_process	amyloid-beta formation
A	0034361	cellular_component	very-low-density lipoprotein particle
A	0034362	cellular_component	low-density lipoprotein particle
A	0034364	cellular_component	high-density lipoprotein particle
A	0034366	cellular_component	spherical high-density lipoprotein particle
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0034380	biological_process	high-density lipoprotein particle assembly
A	0034384	biological_process	high-density lipoprotein particle clearance
A	0034774	cellular_component	secretory granule lumen
A	0035025	biological_process	positive regulation of Rho protein signal transduction
A	0042627	cellular_component	chylomicron
A	0042632	biological_process	cholesterol homeostasis
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043691	biological_process	reverse cholesterol transport
A	0045499	molecular_function	chemorepellent activity
A	0048018	molecular_function	receptor ligand activity
A	0050728	biological_process	negative regulation of inflammatory response
A	0050766	biological_process	positive regulation of phagocytosis
A	0050821	biological_process	protein stabilization
A	0050919	biological_process	negative chemotaxis
A	0051180	biological_process	vitamin transport
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0055090	biological_process	acylglycerol homeostasis
A	0055091	biological_process	phospholipid homeostasis
A	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
A	0060354	biological_process	negative regulation of cell adhesion molecule production
A	0060761	biological_process	negative regulation of response to cytokine stimulus
A	0070062	cellular_component	extracellular exosome
A	0070328	biological_process	triglyceride homeostasis
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070508	biological_process	cholesterol import
A	0070653	molecular_function	high-density lipoprotein particle receptor binding
A	0071402	biological_process	cellular response to lipoprotein particle stimulus
A	0071682	cellular_component	endocytic vesicle lumen
A	0071813	molecular_function	lipoprotein particle binding
A	0072562	cellular_component	blood microparticle
A	0090205	biological_process	positive regulation of cholesterol metabolic process
A	0120020	molecular_function	cholesterol transfer activity
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1902995	biological_process	positive regulation of phospholipid efflux
A	1903561	cellular_component	extracellular vesicle
B	0001540	molecular_function	amyloid-beta binding
B	0002719	biological_process	negative regulation of cytokine production involved in immune response
B	0005102	molecular_function	signaling receptor binding
B	0005319	molecular_function	lipid carrier activity
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005769	cellular_component	early endosome
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006656	biological_process	phosphatidylcholine biosynthetic process
B	0007179	biological_process	transforming growth factor beta receptor signaling pathway
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007229	biological_process	integrin-mediated signaling pathway
B	0008035	molecular_function	high-density lipoprotein particle binding
B	0008203	biological_process	cholesterol metabolic process
B	0008289	molecular_function	lipid binding
B	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
B	0010875	biological_process	positive regulation of cholesterol efflux
B	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
B	0015485	molecular_function	cholesterol binding
B	0018158	biological_process	protein oxidation
B	0018206	biological_process	peptidyl-methionine modification
B	0019899	molecular_function	enzyme binding
B	0030139	cellular_component	endocytic vesicle
B	0030301	biological_process	cholesterol transport
B	0031072	molecular_function	heat shock protein binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0032489	biological_process	regulation of Cdc42 protein signal transduction
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0033344	biological_process	cholesterol efflux
B	0033700	biological_process	phospholipid efflux
B	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
B	0034190	molecular_function	apolipoprotein receptor binding
B	0034191	molecular_function	apolipoprotein A-I receptor binding
B	0034205	biological_process	amyloid-beta formation
B	0034361	cellular_component	very-low-density lipoprotein particle
B	0034362	cellular_component	low-density lipoprotein particle
B	0034364	cellular_component	high-density lipoprotein particle
B	0034366	cellular_component	spherical high-density lipoprotein particle
B	0034375	biological_process	high-density lipoprotein particle remodeling
B	0034380	biological_process	high-density lipoprotein particle assembly
B	0034384	biological_process	high-density lipoprotein particle clearance
B	0034774	cellular_component	secretory granule lumen
B	0035025	biological_process	positive regulation of Rho protein signal transduction
B	0042627	cellular_component	chylomicron
B	0042632	biological_process	cholesterol homeostasis
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043691	biological_process	reverse cholesterol transport
B	0045499	molecular_function	chemorepellent activity
B	0048018	molecular_function	receptor ligand activity
B	0050728	biological_process	negative regulation of inflammatory response
B	0050766	biological_process	positive regulation of phagocytosis
B	0050821	biological_process	protein stabilization
B	0050919	biological_process	negative chemotaxis
B	0051180	biological_process	vitamin transport
B	0051496	biological_process	positive regulation of stress fiber assembly
B	0055090	biological_process	acylglycerol homeostasis
B	0055091	biological_process	phospholipid homeostasis
B	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
B	0060354	biological_process	negative regulation of cell adhesion molecule production
B	0060761	biological_process	negative regulation of response to cytokine stimulus
B	0070062	cellular_component	extracellular exosome
B	0070328	biological_process	triglyceride homeostasis
B	0070371	biological_process	ERK1 and ERK2 cascade
B	0070508	biological_process	cholesterol import
B	0070653	molecular_function	high-density lipoprotein particle receptor binding
B	0071402	biological_process	cellular response to lipoprotein particle stimulus
B	0071682	cellular_component	endocytic vesicle lumen
B	0071813	molecular_function	lipoprotein particle binding
B	0072562	cellular_component	blood microparticle
B	0090205	biological_process	positive regulation of cholesterol metabolic process
B	0120020	molecular_function	cholesterol transfer activity
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	1902995	biological_process	positive regulation of phospholipid efflux
B	1903561	cellular_component	extracellular vesicle
C	0001540	molecular_function	amyloid-beta binding
C	0002719	biological_process	negative regulation of cytokine production involved in immune response
C	0005102	molecular_function	signaling receptor binding
C	0005319	molecular_function	lipid carrier activity
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005769	cellular_component	early endosome
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006656	biological_process	phosphatidylcholine biosynthetic process
C	0007179	biological_process	transforming growth factor beta receptor signaling pathway
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007229	biological_process	integrin-mediated signaling pathway
C	0008035	molecular_function	high-density lipoprotein particle binding
C	0008203	biological_process	cholesterol metabolic process
C	0008289	molecular_function	lipid binding
C	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
C	0010875	biological_process	positive regulation of cholesterol efflux
C	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
C	0015485	molecular_function	cholesterol binding
C	0018158	biological_process	protein oxidation
C	0018206	biological_process	peptidyl-methionine modification
C	0019899	molecular_function	enzyme binding
C	0030139	cellular_component	endocytic vesicle
C	0030301	biological_process	cholesterol transport
C	0031072	molecular_function	heat shock protein binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0032489	biological_process	regulation of Cdc42 protein signal transduction
C	0032691	biological_process	negative regulation of interleukin-1 beta production
C	0033344	biological_process	cholesterol efflux
C	0033700	biological_process	phospholipid efflux
C	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
C	0034190	molecular_function	apolipoprotein receptor binding
C	0034191	molecular_function	apolipoprotein A-I receptor binding
C	0034205	biological_process	amyloid-beta formation
C	0034361	cellular_component	very-low-density lipoprotein particle
C	0034362	cellular_component	low-density lipoprotein particle
C	0034364	cellular_component	high-density lipoprotein particle
C	0034366	cellular_component	spherical high-density lipoprotein particle
C	0034375	biological_process	high-density lipoprotein particle remodeling
C	0034380	biological_process	high-density lipoprotein particle assembly
C	0034384	biological_process	high-density lipoprotein particle clearance
C	0034774	cellular_component	secretory granule lumen
C	0035025	biological_process	positive regulation of Rho protein signal transduction
C	0042627	cellular_component	chylomicron
C	0042632	biological_process	cholesterol homeostasis
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043691	biological_process	reverse cholesterol transport
C	0045499	molecular_function	chemorepellent activity
C	0048018	molecular_function	receptor ligand activity
C	0050728	biological_process	negative regulation of inflammatory response
C	0050766	biological_process	positive regulation of phagocytosis
C	0050821	biological_process	protein stabilization
C	0050919	biological_process	negative chemotaxis
C	0051180	biological_process	vitamin transport
C	0051496	biological_process	positive regulation of stress fiber assembly
C	0055090	biological_process	acylglycerol homeostasis
C	0055091	biological_process	phospholipid homeostasis
C	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
C	0060354	biological_process	negative regulation of cell adhesion molecule production
C	0060761	biological_process	negative regulation of response to cytokine stimulus
C	0070062	cellular_component	extracellular exosome
C	0070328	biological_process	triglyceride homeostasis
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0070508	biological_process	cholesterol import
C	0070653	molecular_function	high-density lipoprotein particle receptor binding
C	0071402	biological_process	cellular response to lipoprotein particle stimulus
C	0071682	cellular_component	endocytic vesicle lumen
C	0071813	molecular_function	lipoprotein particle binding
C	0072562	cellular_component	blood microparticle
C	0090205	biological_process	positive regulation of cholesterol metabolic process
C	0120020	molecular_function	cholesterol transfer activity
C	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
C	1902995	biological_process	positive regulation of phospholipid efflux
C	1903561	cellular_component	extracellular vesicle
D	0001540	molecular_function	amyloid-beta binding
D	0002719	biological_process	negative regulation of cytokine production involved in immune response
D	0005102	molecular_function	signaling receptor binding
D	0005319	molecular_function	lipid carrier activity
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005576	cellular_component	extracellular region
D	0005769	cellular_component	early endosome
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006656	biological_process	phosphatidylcholine biosynthetic process
D	0007179	biological_process	transforming growth factor beta receptor signaling pathway
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007229	biological_process	integrin-mediated signaling pathway
D	0008035	molecular_function	high-density lipoprotein particle binding
D	0008203	biological_process	cholesterol metabolic process
D	0008289	molecular_function	lipid binding
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0010875	biological_process	positive regulation of cholesterol efflux
D	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
D	0015485	molecular_function	cholesterol binding
D	0018158	biological_process	protein oxidation
D	0018206	biological_process	peptidyl-methionine modification
D	0019899	molecular_function	enzyme binding
D	0030139	cellular_component	endocytic vesicle
D	0030301	biological_process	cholesterol transport
D	0031072	molecular_function	heat shock protein binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0032489	biological_process	regulation of Cdc42 protein signal transduction
D	0032691	biological_process	negative regulation of interleukin-1 beta production
D	0033344	biological_process	cholesterol efflux
D	0033700	biological_process	phospholipid efflux
D	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
D	0034190	molecular_function	apolipoprotein receptor binding
D	0034191	molecular_function	apolipoprotein A-I receptor binding
D	0034205	biological_process	amyloid-beta formation
D	0034361	cellular_component	very-low-density lipoprotein particle
D	0034362	cellular_component	low-density lipoprotein particle
D	0034364	cellular_component	high-density lipoprotein particle
D	0034366	cellular_component	spherical high-density lipoprotein particle
D	0034375	biological_process	high-density lipoprotein particle remodeling
D	0034380	biological_process	high-density lipoprotein particle assembly
D	0034384	biological_process	high-density lipoprotein particle clearance
D	0034774	cellular_component	secretory granule lumen
D	0035025	biological_process	positive regulation of Rho protein signal transduction
D	0042627	cellular_component	chylomicron
D	0042632	biological_process	cholesterol homeostasis
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043691	biological_process	reverse cholesterol transport
D	0045499	molecular_function	chemorepellent activity
D	0048018	molecular_function	receptor ligand activity
D	0050728	biological_process	negative regulation of inflammatory response
D	0050766	biological_process	positive regulation of phagocytosis
D	0050821	biological_process	protein stabilization
D	0050919	biological_process	negative chemotaxis
D	0051180	biological_process	vitamin transport
D	0051496	biological_process	positive regulation of stress fiber assembly
D	0055090	biological_process	acylglycerol homeostasis
D	0055091	biological_process	phospholipid homeostasis
D	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
D	0060354	biological_process	negative regulation of cell adhesion molecule production
D	0060761	biological_process	negative regulation of response to cytokine stimulus
D	0070062	cellular_component	extracellular exosome
D	0070328	biological_process	triglyceride homeostasis
D	0070371	biological_process	ERK1 and ERK2 cascade
D	0070508	biological_process	cholesterol import
D	0070653	molecular_function	high-density lipoprotein particle receptor binding
D	0071402	biological_process	cellular response to lipoprotein particle stimulus
D	0071682	cellular_component	endocytic vesicle lumen
D	0071813	molecular_function	lipoprotein particle binding
D	0072562	cellular_component	blood microparticle
D	0090205	biological_process	positive regulation of cholesterol metabolic process
D	0120020	molecular_function	cholesterol transfer activity
D	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
D	1902995	biological_process	positive regulation of phospholipid efflux
D	1903561	cellular_component	extracellular vesicle
E	0001540	molecular_function	amyloid-beta binding
E	0002719	biological_process	negative regulation of cytokine production involved in immune response
E	0005102	molecular_function	signaling receptor binding
E	0005319	molecular_function	lipid carrier activity
E	0005515	molecular_function	protein binding
E	0005543	molecular_function	phospholipid binding
E	0005576	cellular_component	extracellular region
E	0005769	cellular_component	early endosome
E	0005788	cellular_component	endoplasmic reticulum lumen
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006656	biological_process	phosphatidylcholine biosynthetic process
E	0007179	biological_process	transforming growth factor beta receptor signaling pathway
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007229	biological_process	integrin-mediated signaling pathway
E	0008035	molecular_function	high-density lipoprotein particle binding
E	0008203	biological_process	cholesterol metabolic process
E	0008289	molecular_function	lipid binding
E	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
E	0010875	biological_process	positive regulation of cholesterol efflux
E	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
E	0015485	molecular_function	cholesterol binding
E	0018158	biological_process	protein oxidation
E	0018206	biological_process	peptidyl-methionine modification
E	0019899	molecular_function	enzyme binding
E	0030139	cellular_component	endocytic vesicle
E	0030301	biological_process	cholesterol transport
E	0031072	molecular_function	heat shock protein binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0032489	biological_process	regulation of Cdc42 protein signal transduction
E	0032691	biological_process	negative regulation of interleukin-1 beta production
E	0033344	biological_process	cholesterol efflux
E	0033700	biological_process	phospholipid efflux
E	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
E	0034190	molecular_function	apolipoprotein receptor binding
E	0034191	molecular_function	apolipoprotein A-I receptor binding
E	0034205	biological_process	amyloid-beta formation
E	0034361	cellular_component	very-low-density lipoprotein particle
E	0034362	cellular_component	low-density lipoprotein particle
E	0034364	cellular_component	high-density lipoprotein particle
E	0034366	cellular_component	spherical high-density lipoprotein particle
E	0034375	biological_process	high-density lipoprotein particle remodeling
E	0034380	biological_process	high-density lipoprotein particle assembly
E	0034384	biological_process	high-density lipoprotein particle clearance
E	0034774	cellular_component	secretory granule lumen
E	0035025	biological_process	positive regulation of Rho protein signal transduction
E	0042627	cellular_component	chylomicron
E	0042632	biological_process	cholesterol homeostasis
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043691	biological_process	reverse cholesterol transport
E	0045499	molecular_function	chemorepellent activity
E	0048018	molecular_function	receptor ligand activity
E	0050728	biological_process	negative regulation of inflammatory response
E	0050766	biological_process	positive regulation of phagocytosis
E	0050821	biological_process	protein stabilization
E	0050919	biological_process	negative chemotaxis
E	0051180	biological_process	vitamin transport
E	0051496	biological_process	positive regulation of stress fiber assembly
E	0055090	biological_process	acylglycerol homeostasis
E	0055091	biological_process	phospholipid homeostasis
E	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
E	0060354	biological_process	negative regulation of cell adhesion molecule production
E	0060761	biological_process	negative regulation of response to cytokine stimulus
E	0070062	cellular_component	extracellular exosome
E	0070328	biological_process	triglyceride homeostasis
E	0070371	biological_process	ERK1 and ERK2 cascade
E	0070508	biological_process	cholesterol import
E	0070653	molecular_function	high-density lipoprotein particle receptor binding
E	0071402	biological_process	cellular response to lipoprotein particle stimulus
E	0071682	cellular_component	endocytic vesicle lumen
E	0071813	molecular_function	lipoprotein particle binding
E	0072562	cellular_component	blood microparticle
E	0090205	biological_process	positive regulation of cholesterol metabolic process
E	0120020	molecular_function	cholesterol transfer activity
E	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
E	1902995	biological_process	positive regulation of phospholipid efflux
E	1903561	cellular_component	extracellular vesicle
F	0001540	molecular_function	amyloid-beta binding
F	0002719	biological_process	negative regulation of cytokine production involved in immune response
F	0005102	molecular_function	signaling receptor binding
F	0005319	molecular_function	lipid carrier activity
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005576	cellular_component	extracellular region
F	0005769	cellular_component	early endosome
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006656	biological_process	phosphatidylcholine biosynthetic process
F	0007179	biological_process	transforming growth factor beta receptor signaling pathway
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0007229	biological_process	integrin-mediated signaling pathway
F	0008035	molecular_function	high-density lipoprotein particle binding
F	0008203	biological_process	cholesterol metabolic process
F	0008289	molecular_function	lipid binding
F	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
F	0010875	biological_process	positive regulation of cholesterol efflux
F	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
F	0015485	molecular_function	cholesterol binding
F	0018158	biological_process	protein oxidation
F	0018206	biological_process	peptidyl-methionine modification
F	0019899	molecular_function	enzyme binding
F	0030139	cellular_component	endocytic vesicle
F	0030301	biological_process	cholesterol transport
F	0031072	molecular_function	heat shock protein binding
F	0031410	cellular_component	cytoplasmic vesicle
F	0032489	biological_process	regulation of Cdc42 protein signal transduction
F	0032691	biological_process	negative regulation of interleukin-1 beta production
F	0033344	biological_process	cholesterol efflux
F	0033700	biological_process	phospholipid efflux
F	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
F	0034190	molecular_function	apolipoprotein receptor binding
F	0034191	molecular_function	apolipoprotein A-I receptor binding
F	0034205	biological_process	amyloid-beta formation
F	0034361	cellular_component	very-low-density lipoprotein particle
F	0034362	cellular_component	low-density lipoprotein particle
F	0034364	cellular_component	high-density lipoprotein particle
F	0034366	cellular_component	spherical high-density lipoprotein particle
F	0034375	biological_process	high-density lipoprotein particle remodeling
F	0034380	biological_process	high-density lipoprotein particle assembly
F	0034384	biological_process	high-density lipoprotein particle clearance
F	0034774	cellular_component	secretory granule lumen
F	0035025	biological_process	positive regulation of Rho protein signal transduction
F	0042627	cellular_component	chylomicron
F	0042632	biological_process	cholesterol homeostasis
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043691	biological_process	reverse cholesterol transport
F	0045499	molecular_function	chemorepellent activity
F	0048018	molecular_function	receptor ligand activity
F	0050728	biological_process	negative regulation of inflammatory response
F	0050766	biological_process	positive regulation of phagocytosis
F	0050821	biological_process	protein stabilization
F	0050919	biological_process	negative chemotaxis
F	0051180	biological_process	vitamin transport
F	0051496	biological_process	positive regulation of stress fiber assembly
F	0055090	biological_process	acylglycerol homeostasis
F	0055091	biological_process	phospholipid homeostasis
F	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
F	0060354	biological_process	negative regulation of cell adhesion molecule production
F	0060761	biological_process	negative regulation of response to cytokine stimulus
F	0070062	cellular_component	extracellular exosome
F	0070328	biological_process	triglyceride homeostasis
F	0070371	biological_process	ERK1 and ERK2 cascade
F	0070508	biological_process	cholesterol import
F	0070653	molecular_function	high-density lipoprotein particle receptor binding
F	0071402	biological_process	cellular response to lipoprotein particle stimulus
F	0071682	cellular_component	endocytic vesicle lumen
F	0071813	molecular_function	lipoprotein particle binding
F	0072562	cellular_component	blood microparticle
F	0090205	biological_process	positive regulation of cholesterol metabolic process
F	0120020	molecular_function	cholesterol transfer activity
F	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
F	1902995	biological_process	positive regulation of phospholipid efflux
F	1903561	cellular_component	extracellular vesicle
G	0001540	molecular_function	amyloid-beta binding
G	0002719	biological_process	negative regulation of cytokine production involved in immune response
G	0005102	molecular_function	signaling receptor binding
G	0005319	molecular_function	lipid carrier activity
G	0005515	molecular_function	protein binding
G	0005543	molecular_function	phospholipid binding
G	0005576	cellular_component	extracellular region
G	0005769	cellular_component	early endosome
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006656	biological_process	phosphatidylcholine biosynthetic process
G	0007179	biological_process	transforming growth factor beta receptor signaling pathway
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0007229	biological_process	integrin-mediated signaling pathway
G	0008035	molecular_function	high-density lipoprotein particle binding
G	0008203	biological_process	cholesterol metabolic process
G	0008289	molecular_function	lipid binding
G	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
G	0010875	biological_process	positive regulation of cholesterol efflux
G	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
G	0015485	molecular_function	cholesterol binding
G	0018158	biological_process	protein oxidation
G	0018206	biological_process	peptidyl-methionine modification
G	0019899	molecular_function	enzyme binding
G	0030139	cellular_component	endocytic vesicle
G	0030301	biological_process	cholesterol transport
G	0031072	molecular_function	heat shock protein binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0032489	biological_process	regulation of Cdc42 protein signal transduction
G	0032691	biological_process	negative regulation of interleukin-1 beta production
G	0033344	biological_process	cholesterol efflux
G	0033700	biological_process	phospholipid efflux
G	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
G	0034190	molecular_function	apolipoprotein receptor binding
G	0034191	molecular_function	apolipoprotein A-I receptor binding
G	0034205	biological_process	amyloid-beta formation
G	0034361	cellular_component	very-low-density lipoprotein particle
G	0034362	cellular_component	low-density lipoprotein particle
G	0034364	cellular_component	high-density lipoprotein particle
G	0034366	cellular_component	spherical high-density lipoprotein particle
G	0034375	biological_process	high-density lipoprotein particle remodeling
G	0034380	biological_process	high-density lipoprotein particle assembly
G	0034384	biological_process	high-density lipoprotein particle clearance
G	0034774	cellular_component	secretory granule lumen
G	0035025	biological_process	positive regulation of Rho protein signal transduction
G	0042627	cellular_component	chylomicron
G	0042632	biological_process	cholesterol homeostasis
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043691	biological_process	reverse cholesterol transport
G	0045499	molecular_function	chemorepellent activity
G	0048018	molecular_function	receptor ligand activity
G	0050728	biological_process	negative regulation of inflammatory response
G	0050766	biological_process	positive regulation of phagocytosis
G	0050821	biological_process	protein stabilization
G	0050919	biological_process	negative chemotaxis
G	0051180	biological_process	vitamin transport
G	0051496	biological_process	positive regulation of stress fiber assembly
G	0055090	biological_process	acylglycerol homeostasis
G	0055091	biological_process	phospholipid homeostasis
G	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
G	0060354	biological_process	negative regulation of cell adhesion molecule production
G	0060761	biological_process	negative regulation of response to cytokine stimulus
G	0070062	cellular_component	extracellular exosome
G	0070328	biological_process	triglyceride homeostasis
G	0070371	biological_process	ERK1 and ERK2 cascade
G	0070508	biological_process	cholesterol import
G	0070653	molecular_function	high-density lipoprotein particle receptor binding
G	0071402	biological_process	cellular response to lipoprotein particle stimulus
G	0071682	cellular_component	endocytic vesicle lumen
G	0071813	molecular_function	lipoprotein particle binding
G	0072562	cellular_component	blood microparticle
G	0090205	biological_process	positive regulation of cholesterol metabolic process
G	0120020	molecular_function	cholesterol transfer activity
G	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
G	1902995	biological_process	positive regulation of phospholipid efflux
G	1903561	cellular_component	extracellular vesicle
H	0001540	molecular_function	amyloid-beta binding
H	0002719	biological_process	negative regulation of cytokine production involved in immune response
H	0005102	molecular_function	signaling receptor binding
H	0005319	molecular_function	lipid carrier activity
H	0005515	molecular_function	protein binding
H	0005543	molecular_function	phospholipid binding
H	0005576	cellular_component	extracellular region
H	0005769	cellular_component	early endosome
H	0005788	cellular_component	endoplasmic reticulum lumen
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006656	biological_process	phosphatidylcholine biosynthetic process
H	0007179	biological_process	transforming growth factor beta receptor signaling pathway
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007229	biological_process	integrin-mediated signaling pathway
H	0008035	molecular_function	high-density lipoprotein particle binding
H	0008203	biological_process	cholesterol metabolic process
H	0008289	molecular_function	lipid binding
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0010875	biological_process	positive regulation of cholesterol efflux
H	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
H	0015485	molecular_function	cholesterol binding
H	0018158	biological_process	protein oxidation
H	0018206	biological_process	peptidyl-methionine modification
H	0019899	molecular_function	enzyme binding
H	0030139	cellular_component	endocytic vesicle
H	0030301	biological_process	cholesterol transport
H	0031072	molecular_function	heat shock protein binding
H	0031410	cellular_component	cytoplasmic vesicle
H	0032489	biological_process	regulation of Cdc42 protein signal transduction
H	0032691	biological_process	negative regulation of interleukin-1 beta production
H	0033344	biological_process	cholesterol efflux
H	0033700	biological_process	phospholipid efflux
H	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
H	0034190	molecular_function	apolipoprotein receptor binding
H	0034191	molecular_function	apolipoprotein A-I receptor binding
H	0034205	biological_process	amyloid-beta formation
H	0034361	cellular_component	very-low-density lipoprotein particle
H	0034362	cellular_component	low-density lipoprotein particle
H	0034364	cellular_component	high-density lipoprotein particle
H	0034366	cellular_component	spherical high-density lipoprotein particle
H	0034375	biological_process	high-density lipoprotein particle remodeling
H	0034380	biological_process	high-density lipoprotein particle assembly
H	0034384	biological_process	high-density lipoprotein particle clearance
H	0034774	cellular_component	secretory granule lumen
H	0035025	biological_process	positive regulation of Rho protein signal transduction
H	0042627	cellular_component	chylomicron
H	0042632	biological_process	cholesterol homeostasis
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043691	biological_process	reverse cholesterol transport
H	0045499	molecular_function	chemorepellent activity
H	0048018	molecular_function	receptor ligand activity
H	0050728	biological_process	negative regulation of inflammatory response
H	0050766	biological_process	positive regulation of phagocytosis
H	0050821	biological_process	protein stabilization
H	0050919	biological_process	negative chemotaxis
H	0051180	biological_process	vitamin transport
H	0051496	biological_process	positive regulation of stress fiber assembly
H	0055090	biological_process	acylglycerol homeostasis
H	0055091	biological_process	phospholipid homeostasis
H	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
H	0060354	biological_process	negative regulation of cell adhesion molecule production
H	0060761	biological_process	negative regulation of response to cytokine stimulus
H	0070062	cellular_component	extracellular exosome
H	0070328	biological_process	triglyceride homeostasis
H	0070371	biological_process	ERK1 and ERK2 cascade
H	0070508	biological_process	cholesterol import
H	0070653	molecular_function	high-density lipoprotein particle receptor binding
H	0071402	biological_process	cellular response to lipoprotein particle stimulus
H	0071682	cellular_component	endocytic vesicle lumen
H	0071813	molecular_function	lipoprotein particle binding
H	0072562	cellular_component	blood microparticle
H	0090205	biological_process	positive regulation of cholesterol metabolic process
H	0120020	molecular_function	cholesterol transfer activity
H	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
H	1902995	biological_process	positive regulation of phospholipid efflux
H	1903561	cellular_component	extracellular vesicle
I	0001540	molecular_function	amyloid-beta binding
I	0002719	biological_process	negative regulation of cytokine production involved in immune response
I	0005102	molecular_function	signaling receptor binding
I	0005319	molecular_function	lipid carrier activity
I	0005515	molecular_function	protein binding
I	0005543	molecular_function	phospholipid binding
I	0005576	cellular_component	extracellular region
I	0005769	cellular_component	early endosome
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006656	biological_process	phosphatidylcholine biosynthetic process
I	0007179	biological_process	transforming growth factor beta receptor signaling pathway
I	0007186	biological_process	G protein-coupled receptor signaling pathway
I	0007229	biological_process	integrin-mediated signaling pathway
I	0008035	molecular_function	high-density lipoprotein particle binding
I	0008203	biological_process	cholesterol metabolic process
I	0008289	molecular_function	lipid binding
I	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
I	0010875	biological_process	positive regulation of cholesterol efflux
I	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
I	0015485	molecular_function	cholesterol binding
I	0018158	biological_process	protein oxidation
I	0018206	biological_process	peptidyl-methionine modification
I	0019899	molecular_function	enzyme binding
I	0030139	cellular_component	endocytic vesicle
I	0030301	biological_process	cholesterol transport
I	0031072	molecular_function	heat shock protein binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0032489	biological_process	regulation of Cdc42 protein signal transduction
I	0032691	biological_process	negative regulation of interleukin-1 beta production
I	0033344	biological_process	cholesterol efflux
I	0033700	biological_process	phospholipid efflux
I	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
I	0034190	molecular_function	apolipoprotein receptor binding
I	0034191	molecular_function	apolipoprotein A-I receptor binding
I	0034205	biological_process	amyloid-beta formation
I	0034361	cellular_component	very-low-density lipoprotein particle
I	0034362	cellular_component	low-density lipoprotein particle
I	0034364	cellular_component	high-density lipoprotein particle
I	0034366	cellular_component	spherical high-density lipoprotein particle
I	0034375	biological_process	high-density lipoprotein particle remodeling
I	0034380	biological_process	high-density lipoprotein particle assembly
I	0034384	biological_process	high-density lipoprotein particle clearance
I	0034774	cellular_component	secretory granule lumen
I	0035025	biological_process	positive regulation of Rho protein signal transduction
I	0042627	cellular_component	chylomicron
I	0042632	biological_process	cholesterol homeostasis
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043691	biological_process	reverse cholesterol transport
I	0045499	molecular_function	chemorepellent activity
I	0048018	molecular_function	receptor ligand activity
I	0050728	biological_process	negative regulation of inflammatory response
I	0050766	biological_process	positive regulation of phagocytosis
I	0050821	biological_process	protein stabilization
I	0050919	biological_process	negative chemotaxis
I	0051180	biological_process	vitamin transport
I	0051496	biological_process	positive regulation of stress fiber assembly
I	0055090	biological_process	acylglycerol homeostasis
I	0055091	biological_process	phospholipid homeostasis
I	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
I	0060354	biological_process	negative regulation of cell adhesion molecule production
I	0060761	biological_process	negative regulation of response to cytokine stimulus
I	0070062	cellular_component	extracellular exosome
I	0070328	biological_process	triglyceride homeostasis
I	0070371	biological_process	ERK1 and ERK2 cascade
I	0070508	biological_process	cholesterol import
I	0070653	molecular_function	high-density lipoprotein particle receptor binding
I	0071402	biological_process	cellular response to lipoprotein particle stimulus
I	0071682	cellular_component	endocytic vesicle lumen
I	0071813	molecular_function	lipoprotein particle binding
I	0072562	cellular_component	blood microparticle
I	0090205	biological_process	positive regulation of cholesterol metabolic process
I	0120020	molecular_function	cholesterol transfer activity
I	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
I	1902995	biological_process	positive regulation of phospholipid efflux
I	1903561	cellular_component	extracellular vesicle
J	0001540	molecular_function	amyloid-beta binding
J	0002719	biological_process	negative regulation of cytokine production involved in immune response
J	0005102	molecular_function	signaling receptor binding
J	0005319	molecular_function	lipid carrier activity
J	0005515	molecular_function	protein binding
J	0005543	molecular_function	phospholipid binding
J	0005576	cellular_component	extracellular region
J	0005769	cellular_component	early endosome
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006656	biological_process	phosphatidylcholine biosynthetic process
J	0007179	biological_process	transforming growth factor beta receptor signaling pathway
J	0007186	biological_process	G protein-coupled receptor signaling pathway
J	0007229	biological_process	integrin-mediated signaling pathway
J	0008035	molecular_function	high-density lipoprotein particle binding
J	0008203	biological_process	cholesterol metabolic process
J	0008289	molecular_function	lipid binding
J	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
J	0010875	biological_process	positive regulation of cholesterol efflux
J	0010903	biological_process	negative regulation of very-low-density lipoprotein particle remodeling
J	0015485	molecular_function	cholesterol binding
J	0018158	biological_process	protein oxidation
J	0018206	biological_process	peptidyl-methionine modification
J	0019899	molecular_function	enzyme binding
J	0030139	cellular_component	endocytic vesicle
J	0030301	biological_process	cholesterol transport
J	0031072	molecular_function	heat shock protein binding
J	0031410	cellular_component	cytoplasmic vesicle
J	0032489	biological_process	regulation of Cdc42 protein signal transduction
J	0032691	biological_process	negative regulation of interleukin-1 beta production
J	0033344	biological_process	cholesterol efflux
J	0033700	biological_process	phospholipid efflux
J	0034115	biological_process	negative regulation of heterotypic cell-cell adhesion
J	0034190	molecular_function	apolipoprotein receptor binding
J	0034191	molecular_function	apolipoprotein A-I receptor binding
J	0034205	biological_process	amyloid-beta formation
J	0034361	cellular_component	very-low-density lipoprotein particle
J	0034362	cellular_component	low-density lipoprotein particle
J	0034364	cellular_component	high-density lipoprotein particle
J	0034366	cellular_component	spherical high-density lipoprotein particle
J	0034375	biological_process	high-density lipoprotein particle remodeling
J	0034380	biological_process	high-density lipoprotein particle assembly
J	0034384	biological_process	high-density lipoprotein particle clearance
J	0034774	cellular_component	secretory granule lumen
J	0035025	biological_process	positive regulation of Rho protein signal transduction
J	0042627	cellular_component	chylomicron
J	0042632	biological_process	cholesterol homeostasis
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043691	biological_process	reverse cholesterol transport
J	0045499	molecular_function	chemorepellent activity
J	0048018	molecular_function	receptor ligand activity
J	0050728	biological_process	negative regulation of inflammatory response
J	0050766	biological_process	positive regulation of phagocytosis
J	0050821	biological_process	protein stabilization
J	0050919	biological_process	negative chemotaxis
J	0051180	biological_process	vitamin transport
J	0051496	biological_process	positive regulation of stress fiber assembly
J	0055090	biological_process	acylglycerol homeostasis
J	0055091	biological_process	phospholipid homeostasis
J	0060228	molecular_function	phosphatidylcholine-sterol O-acyltransferase activator activity
J	0060354	biological_process	negative regulation of cell adhesion molecule production
J	0060761	biological_process	negative regulation of response to cytokine stimulus
J	0070062	cellular_component	extracellular exosome
J	0070328	biological_process	triglyceride homeostasis
J	0070371	biological_process	ERK1 and ERK2 cascade
J	0070508	biological_process	cholesterol import
J	0070653	molecular_function	high-density lipoprotein particle receptor binding
J	0071402	biological_process	cellular response to lipoprotein particle stimulus
J	0071682	cellular_component	endocytic vesicle lumen
J	0071813	molecular_function	lipoprotein particle binding
J	0072562	cellular_component	blood microparticle
J	0090205	biological_process	positive regulation of cholesterol metabolic process
J	0120020	molecular_function	cholesterol transfer activity
J	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
J	1902995	biological_process	positive regulation of phospholipid efflux
J	1903561	cellular_component	extracellular vesicle

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	210
Details	Repeat: {"description":"1"}

Chain

Residue

Details

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