9PVH
Human Cullin-4 in complex with CAND2
Functional Information from PROSITE/UniProt
| site_id | PS01256 |
| Number of Residues | 28 |
| Details | CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA |
| Chain | Residue | Details |
| A | LEU732-ALA759 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"HEAT 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 21"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 22"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 23"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 24"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 25"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Ramsay A.","Leung H.Y."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
