9PVH
Human Cullin-4 in complex with CAND2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000082 | biological_process | G1/S transition of mitotic cell cycle |
| A | 0000109 | cellular_component | nucleotide-excision repair complex |
| A | 0001701 | biological_process | in utero embryonic development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006289 | biological_process | nucleotide-excision repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0008283 | biological_process | cell population proliferation |
| A | 0010506 | biological_process | regulation of autophagy |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0030174 | biological_process | regulation of DNA-templated DNA replication initiation |
| A | 0031297 | biological_process | replication fork processing |
| A | 0031464 | cellular_component | Cul4A-RING E3 ubiquitin ligase complex |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0032502 | biological_process | developmental process |
| A | 0032814 | biological_process | regulation of natural killer cell activation |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0042110 | biological_process | T cell activation |
| A | 0042127 | biological_process | regulation of cell population proliferation |
| A | 0042254 | biological_process | ribosome biogenesis |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
| A | 0045732 | biological_process | positive regulation of protein catabolic process |
| A | 0045995 | biological_process | regulation of embryonic development |
| A | 0051246 | biological_process | regulation of protein metabolic process |
| A | 0060964 | biological_process | regulation of miRNA-mediated gene silencing |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0080008 | cellular_component | Cul4-RING E3 ubiquitin ligase complex |
| A | 0080135 | biological_process | regulation of cellular response to stress |
| A | 0097193 | biological_process | intrinsic apoptotic signaling pathway |
| A | 0140627 | biological_process | ubiquitin-dependent protein catabolic process via the C-end degron rule pathway |
| A | 0160072 | molecular_function | ubiquitin ligase complex scaffold activity |
| A | 1901987 | biological_process | regulation of cell cycle phase transition |
| A | 1902412 | biological_process | regulation of mitotic cytokinesis |
| A | 1904178 | biological_process | negative regulation of adipose tissue development |
| A | 2000036 | biological_process | regulation of stem cell population maintenance |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005829 | cellular_component | cytosol |
| C | 0010265 | biological_process | SCF complex assembly |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS01256 |
| Number of Residues | 28 |
| Details | CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA |
| Chain | Residue | Details |
| A | LEU732-ALA759 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 13"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 14"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 15"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 16"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 18"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 19"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"HEAT 20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 21"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 22"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 23"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"HEAT 24"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 37 |
| Details | Repeat: {"description":"HEAT 25"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Ramsay A.","Leung H.Y."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}}]} |
| Chain | Residue | Details |
