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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PIE

Cryo-EM structure of human NCC with chlorthalidone (C2)

This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues58
DetailsTransmembrane: {"description":"Discontinuously helical; Name=1","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues182
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues148
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues44
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues68
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues42
DetailsTransmembrane: {"description":"Discontinuously helical; Name=6","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues46
DetailsTransmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues28
DetailsTransmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues32
DetailsTransmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues38
DetailsTransmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues22
DetailsTransmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues30
DetailsRegion: {"description":"Scissor helix","evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"8FHT","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36792826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FHN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FHO","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"36351028","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y6I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

254587

PDB entries from 2026-06-03

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