9PFO

Structure of POU2F3 POU domains bound to coactivator OCA-T2 and DNA (2.1 angstrom resolution)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0070974	molecular_function	POU domain binding
E	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006355	biological_process	regulation of DNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0070974	molecular_function	POU domain binding
I	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
I	0003677	molecular_function	DNA binding
I	0003700	molecular_function	DNA-binding transcription factor activity
I	0006355	biological_process	regulation of DNA-templated transcription
J	0003677	molecular_function	DNA binding
J	0070974	molecular_function	POU domain binding
M	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
M	0003677	molecular_function	DNA binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0006355	biological_process	regulation of DNA-templated transcription
N	0003677	molecular_function	DNA binding
N	0070974	molecular_function	POU domain binding

Functional Information from PROSITE/UniProt

site_id	PS00027
Number of Residues	24
Details	HOMEOBOX_1 'Homeobox' domain signature. IAeqLsMEkeVVRVWFcNrrqkeK

Chain	Residue	Details
A	ILE314-LYS337

---

site_id	PS00035
Number of Residues	13
Details	POU_1 POU-specific (POUs) domain signature 1. RRIkLGFtQgDVG

Chain	Residue	Details
A	ARG201-GLY213

---

site_id	PS00465
Number of Residues	14
Details	POU_2 POU-specific (POUs) domain signature 2. SQTTISRFEaLnLS

Chain	Residue	Details
A	SER225-SER238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	74
Details	Domain: {"description":"POU-specific","evidences":[{"source":"PROSITE-ProRule","id":"PRU00530","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	236
Details	DNA binding: {"description":"Homeobox","evidences":[{"source":"PROSITE-ProRule","id":"PRU00108","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	44
Details	Domain: {"description":"OCA","evidences":[{"source":"PROSITE-ProRule","id":"PRU01347","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---