Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9PCZ

22bin20S complex (NSF-alphaSNAP-2:2 syntaxin-1a:SNAP-25), hydrolyzing, class 15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000149	molecular_function	SNARE binding
A	0000166	molecular_function	nucleotide binding
A	0001921	biological_process	positive regulation of receptor recycling
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005795	cellular_component	Golgi stack
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0006891	biological_process	intra-Golgi vesicle-mediated transport
A	0015031	biological_process	protein transport
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0017075	molecular_function	syntaxin-1 binding
A	0019901	molecular_function	protein kinase binding
A	0019905	molecular_function	syntaxin binding
A	0030165	molecular_function	PDZ domain binding
A	0030496	cellular_component	midbody
A	0035255	molecular_function	ionotropic glutamate receptor binding
A	0035494	biological_process	SNARE complex disassembly
A	0042802	molecular_function	identical protein binding
A	0043001	biological_process	Golgi to plasma membrane protein transport
A	0044877	molecular_function	protein-containing complex binding
A	0045732	biological_process	positive regulation of protein catabolic process
A	0046872	molecular_function	metal ion binding
A	0140545	molecular_function	ATP-dependent protein disaggregase activity
B	0000149	molecular_function	SNARE binding
B	0000166	molecular_function	nucleotide binding
B	0001921	biological_process	positive regulation of receptor recycling
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005795	cellular_component	Golgi stack
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0006891	biological_process	intra-Golgi vesicle-mediated transport
B	0015031	biological_process	protein transport
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0017075	molecular_function	syntaxin-1 binding
B	0019901	molecular_function	protein kinase binding
B	0019905	molecular_function	syntaxin binding
B	0030165	molecular_function	PDZ domain binding
B	0030496	cellular_component	midbody
B	0035255	molecular_function	ionotropic glutamate receptor binding
B	0035494	biological_process	SNARE complex disassembly
B	0042802	molecular_function	identical protein binding
B	0043001	biological_process	Golgi to plasma membrane protein transport
B	0044877	molecular_function	protein-containing complex binding
B	0045732	biological_process	positive regulation of protein catabolic process
B	0046872	molecular_function	metal ion binding
B	0140545	molecular_function	ATP-dependent protein disaggregase activity
C	0000149	molecular_function	SNARE binding
C	0000166	molecular_function	nucleotide binding
C	0001921	biological_process	positive regulation of receptor recycling
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005795	cellular_component	Golgi stack
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006886	biological_process	intracellular protein transport
C	0006891	biological_process	intra-Golgi vesicle-mediated transport
C	0015031	biological_process	protein transport
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0017075	molecular_function	syntaxin-1 binding
C	0019901	molecular_function	protein kinase binding
C	0019905	molecular_function	syntaxin binding
C	0030165	molecular_function	PDZ domain binding
C	0030496	cellular_component	midbody
C	0035255	molecular_function	ionotropic glutamate receptor binding
C	0035494	biological_process	SNARE complex disassembly
C	0042802	molecular_function	identical protein binding
C	0043001	biological_process	Golgi to plasma membrane protein transport
C	0044877	molecular_function	protein-containing complex binding
C	0045732	biological_process	positive regulation of protein catabolic process
C	0046872	molecular_function	metal ion binding
C	0140545	molecular_function	ATP-dependent protein disaggregase activity
D	0000149	molecular_function	SNARE binding
D	0000166	molecular_function	nucleotide binding
D	0001921	biological_process	positive regulation of receptor recycling
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005795	cellular_component	Golgi stack
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006886	biological_process	intracellular protein transport
D	0006891	biological_process	intra-Golgi vesicle-mediated transport
D	0015031	biological_process	protein transport
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0017075	molecular_function	syntaxin-1 binding
D	0019901	molecular_function	protein kinase binding
D	0019905	molecular_function	syntaxin binding
D	0030165	molecular_function	PDZ domain binding
D	0030496	cellular_component	midbody
D	0035255	molecular_function	ionotropic glutamate receptor binding
D	0035494	biological_process	SNARE complex disassembly
D	0042802	molecular_function	identical protein binding
D	0043001	biological_process	Golgi to plasma membrane protein transport
D	0044877	molecular_function	protein-containing complex binding
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046872	molecular_function	metal ion binding
D	0140545	molecular_function	ATP-dependent protein disaggregase activity
E	0000149	molecular_function	SNARE binding
E	0000166	molecular_function	nucleotide binding
E	0001921	biological_process	positive regulation of receptor recycling
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005795	cellular_component	Golgi stack
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006886	biological_process	intracellular protein transport
E	0006891	biological_process	intra-Golgi vesicle-mediated transport
E	0015031	biological_process	protein transport
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0017075	molecular_function	syntaxin-1 binding
E	0019901	molecular_function	protein kinase binding
E	0019905	molecular_function	syntaxin binding
E	0030165	molecular_function	PDZ domain binding
E	0030496	cellular_component	midbody
E	0035255	molecular_function	ionotropic glutamate receptor binding
E	0035494	biological_process	SNARE complex disassembly
E	0042802	molecular_function	identical protein binding
E	0043001	biological_process	Golgi to plasma membrane protein transport
E	0044877	molecular_function	protein-containing complex binding
E	0045732	biological_process	positive regulation of protein catabolic process
E	0046872	molecular_function	metal ion binding
E	0140545	molecular_function	ATP-dependent protein disaggregase activity
F	0000149	molecular_function	SNARE binding
F	0000166	molecular_function	nucleotide binding
F	0001921	biological_process	positive regulation of receptor recycling
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005795	cellular_component	Golgi stack
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006886	biological_process	intracellular protein transport
F	0006891	biological_process	intra-Golgi vesicle-mediated transport
F	0015031	biological_process	protein transport
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0017075	molecular_function	syntaxin-1 binding
F	0019901	molecular_function	protein kinase binding
F	0019905	molecular_function	syntaxin binding
F	0030165	molecular_function	PDZ domain binding
F	0030496	cellular_component	midbody
F	0035255	molecular_function	ionotropic glutamate receptor binding
F	0035494	biological_process	SNARE complex disassembly
F	0042802	molecular_function	identical protein binding
F	0043001	biological_process	Golgi to plasma membrane protein transport
F	0044877	molecular_function	protein-containing complex binding
F	0045732	biological_process	positive regulation of protein catabolic process
F	0046872	molecular_function	metal ion binding
F	0140545	molecular_function	ATP-dependent protein disaggregase activity
I	0000149	molecular_function	SNARE binding
I	0001669	cellular_component	acrosomal vesicle
I	0001956	biological_process	positive regulation of neurotransmitter secretion
I	0005484	molecular_function	SNAP receptor activity
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006836	biological_process	neurotransmitter transport
I	0006886	biological_process	intracellular protein transport
I	0006887	biological_process	exocytosis
I	0006906	biological_process	vesicle fusion
I	0008021	cellular_component	synaptic vesicle
I	0008076	cellular_component	voltage-gated potassium channel complex
I	0009629	biological_process	response to gravity
I	0010701	biological_process	positive regulation of norepinephrine secretion
I	0010807	biological_process	regulation of synaptic vesicle priming
I	0012505	cellular_component	endomembrane system
I	0016020	cellular_component	membrane
I	0016079	biological_process	synaptic vesicle exocytosis
I	0016081	biological_process	synaptic vesicle docking
I	0016192	biological_process	vesicle-mediated transport
I	0016925	biological_process	protein sumoylation
I	0017022	molecular_function	myosin binding
I	0017156	biological_process	calcium-ion regulated exocytosis
I	0017157	biological_process	regulation of exocytosis
I	0019855	molecular_function	calcium channel inhibitor activity
I	0019869	molecular_function	chloride channel inhibitor activity
I	0019900	molecular_function	kinase binding
I	0030073	biological_process	insulin secretion
I	0030141	cellular_component	secretory granule
I	0030424	cellular_component	axon
I	0030672	cellular_component	synaptic vesicle membrane
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031201	cellular_component	SNARE complex
I	0031410	cellular_component	cytoplasmic vesicle
I	0031965	cellular_component	nuclear membrane
I	0032028	molecular_function	myosin head/neck binding
I	0032940	biological_process	secretion by cell
I	0032991	cellular_component	protein-containing complex
I	0033605	biological_process	positive regulation of catecholamine secretion
I	0035493	biological_process	SNARE complex assembly
I	0035494	biological_process	SNARE complex disassembly
I	0042641	cellular_component	actomyosin
I	0042734	cellular_component	presynaptic membrane
I	0042802	molecular_function	identical protein binding
I	0043005	cellular_component	neuron projection
I	0043008	molecular_function	ATP-dependent protein binding
I	0044325	molecular_function	transmembrane transporter binding
I	0044877	molecular_function	protein-containing complex binding
I	0045055	biological_process	regulated exocytosis
I	0045202	cellular_component	synapse
I	0045921	biological_process	positive regulation of exocytosis
I	0045956	biological_process	positive regulation of calcium ion-dependent exocytosis
I	0046879	biological_process	hormone secretion
I	0048278	biological_process	vesicle docking
I	0048306	molecular_function	calcium-dependent protein binding
I	0048488	biological_process	synaptic vesicle endocytosis
I	0048787	cellular_component	presynaptic active zone membrane
I	0070032	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
I	0070033	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
I	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
I	0072657	biological_process	protein localization to membrane
I	0098685	cellular_component	Schaffer collateral - CA1 synapse
I	0098793	cellular_component	presynapse
I	0098815	biological_process	modulation of excitatory postsynaptic potential
I	0098839	cellular_component	postsynaptic density membrane
I	0098978	cellular_component	glutamatergic synapse
I	1903530	biological_process	regulation of secretion by cell
I	2000463	biological_process	positive regulation of excitatory postsynaptic potential
J	0000149	molecular_function	SNARE binding
J	0001669	cellular_component	acrosomal vesicle
J	0001956	biological_process	positive regulation of neurotransmitter secretion
J	0005484	molecular_function	SNAP receptor activity
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0006836	biological_process	neurotransmitter transport
J	0006886	biological_process	intracellular protein transport
J	0006887	biological_process	exocytosis
J	0006906	biological_process	vesicle fusion
J	0008021	cellular_component	synaptic vesicle
J	0008076	cellular_component	voltage-gated potassium channel complex
J	0009629	biological_process	response to gravity
J	0010701	biological_process	positive regulation of norepinephrine secretion
J	0010807	biological_process	regulation of synaptic vesicle priming
J	0012505	cellular_component	endomembrane system
J	0016020	cellular_component	membrane
J	0016079	biological_process	synaptic vesicle exocytosis
J	0016081	biological_process	synaptic vesicle docking
J	0016192	biological_process	vesicle-mediated transport
J	0016925	biological_process	protein sumoylation
J	0017022	molecular_function	myosin binding
J	0017156	biological_process	calcium-ion regulated exocytosis
J	0017157	biological_process	regulation of exocytosis
J	0019855	molecular_function	calcium channel inhibitor activity
J	0019869	molecular_function	chloride channel inhibitor activity
J	0019900	molecular_function	kinase binding
J	0030073	biological_process	insulin secretion
J	0030141	cellular_component	secretory granule
J	0030424	cellular_component	axon
J	0030672	cellular_component	synaptic vesicle membrane
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031201	cellular_component	SNARE complex
J	0031410	cellular_component	cytoplasmic vesicle
J	0031965	cellular_component	nuclear membrane
J	0032028	molecular_function	myosin head/neck binding
J	0032940	biological_process	secretion by cell
J	0032991	cellular_component	protein-containing complex
J	0033605	biological_process	positive regulation of catecholamine secretion
J	0035493	biological_process	SNARE complex assembly
J	0035494	biological_process	SNARE complex disassembly
J	0042641	cellular_component	actomyosin
J	0042734	cellular_component	presynaptic membrane
J	0042802	molecular_function	identical protein binding
J	0043005	cellular_component	neuron projection
J	0043008	molecular_function	ATP-dependent protein binding
J	0044325	molecular_function	transmembrane transporter binding
J	0044877	molecular_function	protein-containing complex binding
J	0045055	biological_process	regulated exocytosis
J	0045202	cellular_component	synapse
J	0045921	biological_process	positive regulation of exocytosis
J	0045956	biological_process	positive regulation of calcium ion-dependent exocytosis
J	0046879	biological_process	hormone secretion
J	0048278	biological_process	vesicle docking
J	0048306	molecular_function	calcium-dependent protein binding
J	0048488	biological_process	synaptic vesicle endocytosis
J	0048787	cellular_component	presynaptic active zone membrane
J	0070032	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
J	0070033	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
J	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
J	0072657	biological_process	protein localization to membrane
J	0098685	cellular_component	Schaffer collateral - CA1 synapse
J	0098793	cellular_component	presynapse
J	0098815	biological_process	modulation of excitatory postsynaptic potential
J	0098839	cellular_component	postsynaptic density membrane
J	0098978	cellular_component	glutamatergic synapse
J	1903530	biological_process	regulation of secretion by cell
J	2000463	biological_process	positive regulation of excitatory postsynaptic potential
K	0000149	molecular_function	SNARE binding
K	0001917	cellular_component	photoreceptor inner segment
K	0005249	molecular_function	voltage-gated potassium channel activity
K	0005484	molecular_function	SNAP receptor activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005768	cellular_component	endosome
K	0005802	cellular_component	trans-Golgi network
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0005938	cellular_component	cell cortex
K	0006887	biological_process	exocytosis
K	0006906	biological_process	vesicle fusion
K	0007269	biological_process	neurotransmitter secretion
K	0007409	biological_process	axonogenesis
K	0007616	biological_process	long-term memory
K	0007626	biological_process	locomotory behavior
K	0008021	cellular_component	synaptic vesicle
K	0008076	cellular_component	voltage-gated potassium channel complex
K	0008289	molecular_function	lipid binding
K	0008306	biological_process	associative learning
K	0010975	biological_process	regulation of neuron projection development
K	0015629	cellular_component	actin cytoskeleton
K	0016020	cellular_component	membrane
K	0016079	biological_process	synaptic vesicle exocytosis
K	0016082	biological_process	synaptic vesicle priming
K	0016197	biological_process	endosomal transport
K	0017022	molecular_function	myosin binding
K	0017075	molecular_function	syntaxin-1 binding
K	0019904	molecular_function	protein domain specific binding
K	0030027	cellular_component	lamellipodium
K	0030073	biological_process	insulin secretion
K	0030175	cellular_component	filopodium
K	0030182	biological_process	neuron differentiation
K	0030424	cellular_component	axon
K	0030426	cellular_component	growth cone
K	0031083	cellular_component	BLOC-1 complex
K	0031201	cellular_component	SNARE complex
K	0031340	biological_process	positive regulation of vesicle fusion
K	0031629	biological_process	synaptic vesicle fusion to presynaptic active zone membrane
K	0031915	biological_process	positive regulation of synaptic plasticity
K	0031982	cellular_component	vesicle
K	0032024	biological_process	positive regulation of insulin secretion
K	0035493	biological_process	SNARE complex assembly
K	0036477	cellular_component	somatodendritic compartment
K	0042734	cellular_component	presynaptic membrane
K	0043005	cellular_component	neuron projection
K	0043025	cellular_component	neuronal cell body
K	0043195	cellular_component	terminal bouton
K	0044295	cellular_component	axonal growth cone
K	0044325	molecular_function	transmembrane transporter binding
K	0045202	cellular_component	synapse
K	0046887	biological_process	positive regulation of hormone secretion
K	0048306	molecular_function	calcium-dependent protein binding
K	0048471	cellular_component	perinuclear region of cytoplasm
K	0048791	biological_process	calcium ion-regulated exocytosis of neurotransmitter
K	0051963	biological_process	regulation of synapse assembly
K	0060291	biological_process	long-term synaptic potentiation
K	0061025	biological_process	membrane fusion
K	0070032	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
K	0070033	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
K	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
K	0070201	biological_process	regulation of establishment of protein localization
K	0071805	biological_process	potassium ion transmembrane transport
K	0097470	cellular_component	ribbon synapse
K	0098693	biological_process	regulation of synaptic vesicle cycle
K	0098888	cellular_component	extrinsic component of presynaptic membrane
K	0098978	cellular_component	glutamatergic synapse
K	0099525	biological_process	presynaptic dense core vesicle exocytosis
K	1901387	biological_process	positive regulation of voltage-gated calcium channel activity
K	1903296	biological_process	positive regulation of glutamate secretion, neurotransmission
K	1990926	biological_process	short-term synaptic potentiation
L	0000149	molecular_function	SNARE binding
L	0001917	cellular_component	photoreceptor inner segment
L	0005249	molecular_function	voltage-gated potassium channel activity
L	0005484	molecular_function	SNAP receptor activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005768	cellular_component	endosome
L	0005802	cellular_component	trans-Golgi network
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005938	cellular_component	cell cortex
L	0006887	biological_process	exocytosis
L	0006906	biological_process	vesicle fusion
L	0007269	biological_process	neurotransmitter secretion
L	0007409	biological_process	axonogenesis
L	0007616	biological_process	long-term memory
L	0007626	biological_process	locomotory behavior
L	0008021	cellular_component	synaptic vesicle
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0008289	molecular_function	lipid binding
L	0008306	biological_process	associative learning
L	0010975	biological_process	regulation of neuron projection development
L	0015629	cellular_component	actin cytoskeleton
L	0016020	cellular_component	membrane
L	0016079	biological_process	synaptic vesicle exocytosis
L	0016082	biological_process	synaptic vesicle priming
L	0016197	biological_process	endosomal transport
L	0017022	molecular_function	myosin binding
L	0017075	molecular_function	syntaxin-1 binding
L	0019904	molecular_function	protein domain specific binding
L	0030027	cellular_component	lamellipodium
L	0030073	biological_process	insulin secretion
L	0030175	cellular_component	filopodium
L	0030182	biological_process	neuron differentiation
L	0030424	cellular_component	axon
L	0030426	cellular_component	growth cone
L	0031083	cellular_component	BLOC-1 complex
L	0031201	cellular_component	SNARE complex
L	0031340	biological_process	positive regulation of vesicle fusion
L	0031629	biological_process	synaptic vesicle fusion to presynaptic active zone membrane
L	0031915	biological_process	positive regulation of synaptic plasticity
L	0031982	cellular_component	vesicle
L	0032024	biological_process	positive regulation of insulin secretion
L	0035493	biological_process	SNARE complex assembly
L	0036477	cellular_component	somatodendritic compartment
L	0042734	cellular_component	presynaptic membrane
L	0043005	cellular_component	neuron projection
L	0043025	cellular_component	neuronal cell body
L	0043195	cellular_component	terminal bouton
L	0044295	cellular_component	axonal growth cone
L	0044325	molecular_function	transmembrane transporter binding
L	0045202	cellular_component	synapse
L	0046887	biological_process	positive regulation of hormone secretion
L	0048306	molecular_function	calcium-dependent protein binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0048791	biological_process	calcium ion-regulated exocytosis of neurotransmitter
L	0051963	biological_process	regulation of synapse assembly
L	0060291	biological_process	long-term synaptic potentiation
L	0061025	biological_process	membrane fusion
L	0070032	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
L	0070033	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
L	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
L	0070201	biological_process	regulation of establishment of protein localization
L	0071805	biological_process	potassium ion transmembrane transport
L	0097470	cellular_component	ribbon synapse
L	0098693	biological_process	regulation of synaptic vesicle cycle
L	0098888	cellular_component	extrinsic component of presynaptic membrane
L	0098978	cellular_component	glutamatergic synapse
L	0099525	biological_process	presynaptic dense core vesicle exocytosis
L	1901387	biological_process	positive regulation of voltage-gated calcium channel activity
L	1903296	biological_process	positive regulation of glutamate secretion, neurotransmission
L	1990926	biological_process	short-term synaptic potentiation
M	0000149	molecular_function	SNARE binding
M	0005483	molecular_function	soluble NSF attachment protein activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005886	cellular_component	plasma membrane
M	0006886	biological_process	intracellular protein transport
M	0007420	biological_process	brain development
M	0008021	cellular_component	synaptic vesicle
M	0010807	biological_process	regulation of synaptic vesicle priming
M	0015031	biological_process	protein transport
M	0016082	biological_process	synaptic vesicle priming
M	0016192	biological_process	vesicle-mediated transport
M	0019905	molecular_function	syntaxin binding
M	0030182	biological_process	neuron differentiation
M	0030425	cellular_component	dendrite
M	0031410	cellular_component	cytoplasmic vesicle
M	0031594	cellular_component	neuromuscular junction
M	0032781	biological_process	positive regulation of ATP-dependent activity
M	0032984	biological_process	protein-containing complex disassembly
M	0035249	biological_process	synaptic transmission, glutamatergic
M	0035494	biological_process	SNARE complex disassembly
M	0042599	cellular_component	lamellar body
M	0042734	cellular_component	presynaptic membrane
M	0043195	cellular_component	terminal bouton
M	0043204	cellular_component	perikaryon
M	0044877	molecular_function	protein-containing complex binding
M	0045176	biological_process	apical protein localization
M	0045211	cellular_component	postsynaptic membrane
M	0048787	cellular_component	presynaptic active zone membrane
M	0055093	biological_process	response to hyperoxia
M	0061025	biological_process	membrane fusion
M	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
M	0097060	cellular_component	synaptic membrane
M	0098793	cellular_component	presynapse
M	0098794	cellular_component	postsynapse
M	0098978	cellular_component	glutamatergic synapse
N	0000149	molecular_function	SNARE binding
N	0005483	molecular_function	soluble NSF attachment protein activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005886	cellular_component	plasma membrane
N	0006886	biological_process	intracellular protein transport
N	0007420	biological_process	brain development
N	0008021	cellular_component	synaptic vesicle
N	0010807	biological_process	regulation of synaptic vesicle priming
N	0015031	biological_process	protein transport
N	0016082	biological_process	synaptic vesicle priming
N	0016192	biological_process	vesicle-mediated transport
N	0019905	molecular_function	syntaxin binding
N	0030182	biological_process	neuron differentiation
N	0030425	cellular_component	dendrite
N	0031410	cellular_component	cytoplasmic vesicle
N	0031594	cellular_component	neuromuscular junction
N	0032781	biological_process	positive regulation of ATP-dependent activity
N	0032984	biological_process	protein-containing complex disassembly
N	0035249	biological_process	synaptic transmission, glutamatergic
N	0035494	biological_process	SNARE complex disassembly
N	0042599	cellular_component	lamellar body
N	0042734	cellular_component	presynaptic membrane
N	0043195	cellular_component	terminal bouton
N	0043204	cellular_component	perikaryon
N	0044877	molecular_function	protein-containing complex binding
N	0045176	biological_process	apical protein localization
N	0045211	cellular_component	postsynaptic membrane
N	0048787	cellular_component	presynaptic active zone membrane
N	0055093	biological_process	response to hyperoxia
N	0061025	biological_process	membrane fusion
N	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
N	0097060	cellular_component	synaptic membrane
N	0098793	cellular_component	presynapse
N	0098794	cellular_component	postsynapse
N	0098978	cellular_component	glutamatergic synapse
O	0000149	molecular_function	SNARE binding
O	0005483	molecular_function	soluble NSF attachment protein activity
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005886	cellular_component	plasma membrane
O	0006886	biological_process	intracellular protein transport
O	0007420	biological_process	brain development
O	0008021	cellular_component	synaptic vesicle
O	0010807	biological_process	regulation of synaptic vesicle priming
O	0015031	biological_process	protein transport
O	0016082	biological_process	synaptic vesicle priming
O	0016192	biological_process	vesicle-mediated transport
O	0019905	molecular_function	syntaxin binding
O	0030182	biological_process	neuron differentiation
O	0030425	cellular_component	dendrite
O	0031410	cellular_component	cytoplasmic vesicle
O	0031594	cellular_component	neuromuscular junction
O	0032781	biological_process	positive regulation of ATP-dependent activity
O	0032984	biological_process	protein-containing complex disassembly
O	0035249	biological_process	synaptic transmission, glutamatergic
O	0035494	biological_process	SNARE complex disassembly
O	0042599	cellular_component	lamellar body
O	0042734	cellular_component	presynaptic membrane
O	0043195	cellular_component	terminal bouton
O	0043204	cellular_component	perikaryon
O	0044877	molecular_function	protein-containing complex binding
O	0045176	biological_process	apical protein localization
O	0045211	cellular_component	postsynaptic membrane
O	0048787	cellular_component	presynaptic active zone membrane
O	0055093	biological_process	response to hyperoxia
O	0061025	biological_process	membrane fusion
O	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
O	0097060	cellular_component	synaptic membrane
O	0098793	cellular_component	presynapse
O	0098794	cellular_component	postsynapse
O	0098978	cellular_component	glutamatergic synapse
P	0000149	molecular_function	SNARE binding
P	0005483	molecular_function	soluble NSF attachment protein activity
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005886	cellular_component	plasma membrane
P	0006886	biological_process	intracellular protein transport
P	0007420	biological_process	brain development
P	0008021	cellular_component	synaptic vesicle
P	0010807	biological_process	regulation of synaptic vesicle priming
P	0015031	biological_process	protein transport
P	0016082	biological_process	synaptic vesicle priming
P	0016192	biological_process	vesicle-mediated transport
P	0019905	molecular_function	syntaxin binding
P	0030182	biological_process	neuron differentiation
P	0030425	cellular_component	dendrite
P	0031410	cellular_component	cytoplasmic vesicle
P	0031594	cellular_component	neuromuscular junction
P	0032781	biological_process	positive regulation of ATP-dependent activity
P	0032984	biological_process	protein-containing complex disassembly
P	0035249	biological_process	synaptic transmission, glutamatergic
P	0035494	biological_process	SNARE complex disassembly
P	0042599	cellular_component	lamellar body
P	0042734	cellular_component	presynaptic membrane
P	0043195	cellular_component	terminal bouton
P	0043204	cellular_component	perikaryon
P	0044877	molecular_function	protein-containing complex binding
P	0045176	biological_process	apical protein localization
P	0045211	cellular_component	postsynaptic membrane
P	0048787	cellular_component	presynaptic active zone membrane
P	0055093	biological_process	response to hyperoxia
P	0061025	biological_process	membrane fusion
P	0070044	cellular_component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
P	0097060	cellular_component	synaptic membrane
P	0098793	cellular_component	presynapse
P	0098794	cellular_component	postsynapse
P	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IlVIgMTNrpdlIDeALl.R

Chain	Residue	Details
A	ILE367-ARG385

site_id	PS00914
Number of Residues	40
Details	SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V

Chain	Residue	Details
I	ARG198-VAL237

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9727495","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	5
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46459","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by CDK16","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	62
Details	Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DB05","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
A	LYS549	electrostatic stabiliser
A	THR550	electrostatic stabiliser
A	ASP603	electrostatic stabiliser
A	ASP604	proton acceptor
A	LYS631	electrostatic stabiliser
A	LYS708	electrostatic stabiliser

site_id	MCSA2
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
B	LYS549	electrostatic stabiliser
B	THR550	electrostatic stabiliser
B	ASP603	electrostatic stabiliser
B	ASP604	proton acceptor
B	LYS631	electrostatic stabiliser
B	LYS708	electrostatic stabiliser

site_id	MCSA3
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
C	LYS549	electrostatic stabiliser
C	THR550	electrostatic stabiliser
C	ASP603	electrostatic stabiliser
C	ASP604	proton acceptor
C	LYS631	electrostatic stabiliser
C	LYS708	electrostatic stabiliser

site_id	MCSA4
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
D	LYS549	electrostatic stabiliser
D	THR550	electrostatic stabiliser
D	ASP603	electrostatic stabiliser
D	ASP604	proton acceptor
D	LYS631	electrostatic stabiliser
D	LYS708	electrostatic stabiliser

site_id	MCSA5
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
E	LYS549	electrostatic stabiliser
E	THR550	electrostatic stabiliser
E	ASP603	electrostatic stabiliser
E	ASP604	proton acceptor
E	LYS631	electrostatic stabiliser
E	LYS708	electrostatic stabiliser

site_id	MCSA6
Number of Residues	6
Details	M-CSA 642

Chain	Residue	Details
F	LYS549	electrostatic stabiliser
F	THR550	electrostatic stabiliser
F	ASP603	electrostatic stabiliser
F	ASP604	proton acceptor
F	LYS631	electrostatic stabiliser
F	LYS708	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)