Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. IlVIgMTNrpdlIDeALl.R |
| Chain | Residue | Details |
| A | ILE367-ARG385 | |
| site_id | PS00914 |
| Number of Residues | 40 |
| Details | SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V |
| Chain | Residue | Details |
| H | ARG198-VAL237 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9727495","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46459","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphoserine; by CDK16","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 124 |
| Details | Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 124 |
| Details | Domain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| A | LYS549 | electrostatic stabiliser |
| A | THR550 | electrostatic stabiliser |
| A | ASP603 | electrostatic stabiliser |
| A | ASP604 | proton acceptor |
| A | LYS631 | electrostatic stabiliser |
| A | LYS708 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| B | LYS549 | electrostatic stabiliser |
| B | THR550 | electrostatic stabiliser |
| B | ASP603 | electrostatic stabiliser |
| B | ASP604 | proton acceptor |
| B | LYS631 | electrostatic stabiliser |
| B | LYS708 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| C | LYS549 | electrostatic stabiliser |
| C | THR550 | electrostatic stabiliser |
| C | ASP603 | electrostatic stabiliser |
| C | ASP604 | proton acceptor |
| C | LYS631 | electrostatic stabiliser |
| C | LYS708 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| D | LYS549 | electrostatic stabiliser |
| D | THR550 | electrostatic stabiliser |
| D | ASP603 | electrostatic stabiliser |
| D | ASP604 | proton acceptor |
| D | LYS631 | electrostatic stabiliser |
| D | LYS708 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| E | LYS549 | electrostatic stabiliser |
| E | THR550 | electrostatic stabiliser |
| E | ASP603 | electrostatic stabiliser |
| E | ASP604 | proton acceptor |
| E | LYS631 | electrostatic stabiliser |
| E | LYS708 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 6 |
| Details | M-CSA 642 |
| Chain | Residue | Details |
| F | LYS549 | electrostatic stabiliser |
| F | THR550 | electrostatic stabiliser |
| F | ASP603 | electrostatic stabiliser |
| F | ASP604 | proton acceptor |
| F | LYS631 | electrostatic stabiliser |
| F | LYS708 | electrostatic stabiliser |
