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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PC3

21bin20S complex (NSF-alphaSNAP-2:1 syntaxin-1a:SNAP-25), non-hydrolyzing, class 12

Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IlVIgMTNrpdlIDeALl.R
ChainResidueDetails
AILE367-ARG385
site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
GARG198-VAL237
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9727495","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine; by CDK16","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46459","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues74
DetailsRegion: {"description":"Interaction with CENPF","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues22
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues19
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKC and PKA","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues3
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DB05","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
ALYS549electrostatic stabiliser
ATHR550electrostatic stabiliser
AASP603electrostatic stabiliser
AASP604proton acceptor
ALYS631electrostatic stabiliser
ALYS708electrostatic stabiliser
site_idMCSA2
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
BLYS549electrostatic stabiliser
BTHR550electrostatic stabiliser
BASP603electrostatic stabiliser
BASP604proton acceptor
BLYS631electrostatic stabiliser
BLYS708electrostatic stabiliser
site_idMCSA3
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
CLYS549electrostatic stabiliser
CTHR550electrostatic stabiliser
CASP603electrostatic stabiliser
CASP604proton acceptor
CLYS631electrostatic stabiliser
CLYS708electrostatic stabiliser
site_idMCSA4
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
DLYS549electrostatic stabiliser
DTHR550electrostatic stabiliser
DASP603electrostatic stabiliser
DASP604proton acceptor
DLYS631electrostatic stabiliser
DLYS708electrostatic stabiliser
site_idMCSA5
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
ELYS549electrostatic stabiliser
ETHR550electrostatic stabiliser
EASP603electrostatic stabiliser
EASP604proton acceptor
ELYS631electrostatic stabiliser
ELYS708electrostatic stabiliser
site_idMCSA6
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
FLYS549electrostatic stabiliser
FTHR550electrostatic stabiliser
FASP603electrostatic stabiliser
FASP604proton acceptor
FLYS631electrostatic stabiliser
FLYS708electrostatic stabiliser

239803

PDB entries from 2025-08-06

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