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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PC3

21bin20S complex (NSF-alphaSNAP-2:1 syntaxin-1a:SNAP-25), non-hydrolyzing, class 12

Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0000166molecular_functionnucleotide binding
A0001921biological_processpositive regulation of receptor recycling
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005794cellular_componentGolgi apparatus
A0005795cellular_componentGolgi stack
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006813biological_processpotassium ion transport
A0006886biological_processintracellular protein transport
A0006891biological_processintra-Golgi vesicle-mediated transport
A0015031biological_processprotein transport
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017075molecular_functionsyntaxin-1 binding
A0019901molecular_functionprotein kinase binding
A0019905molecular_functionsyntaxin binding
A0030165molecular_functionPDZ domain binding
A0030496cellular_componentmidbody
A0035255molecular_functionionotropic glutamate receptor binding
A0035494biological_processSNARE complex disassembly
A0042802molecular_functionidentical protein binding
A0043001biological_processGolgi to plasma membrane protein transport
A0044877molecular_functionprotein-containing complex binding
A0045732biological_processpositive regulation of protein catabolic process
A0046872molecular_functionmetal ion binding
A0140545molecular_functionATP-dependent protein disaggregase activity
B0000149molecular_functionSNARE binding
B0000166molecular_functionnucleotide binding
B0001921biological_processpositive regulation of receptor recycling
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005794cellular_componentGolgi apparatus
B0005795cellular_componentGolgi stack
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006813biological_processpotassium ion transport
B0006886biological_processintracellular protein transport
B0006891biological_processintra-Golgi vesicle-mediated transport
B0015031biological_processprotein transport
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017075molecular_functionsyntaxin-1 binding
B0019901molecular_functionprotein kinase binding
B0019905molecular_functionsyntaxin binding
B0030165molecular_functionPDZ domain binding
B0030496cellular_componentmidbody
B0035255molecular_functionionotropic glutamate receptor binding
B0035494biological_processSNARE complex disassembly
B0042802molecular_functionidentical protein binding
B0043001biological_processGolgi to plasma membrane protein transport
B0044877molecular_functionprotein-containing complex binding
B0045732biological_processpositive regulation of protein catabolic process
B0046872molecular_functionmetal ion binding
B0140545molecular_functionATP-dependent protein disaggregase activity
C0000149molecular_functionSNARE binding
C0000166molecular_functionnucleotide binding
C0001921biological_processpositive regulation of receptor recycling
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005794cellular_componentGolgi apparatus
C0005795cellular_componentGolgi stack
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006813biological_processpotassium ion transport
C0006886biological_processintracellular protein transport
C0006891biological_processintra-Golgi vesicle-mediated transport
C0015031biological_processprotein transport
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017075molecular_functionsyntaxin-1 binding
C0019901molecular_functionprotein kinase binding
C0019905molecular_functionsyntaxin binding
C0030165molecular_functionPDZ domain binding
C0030496cellular_componentmidbody
C0035255molecular_functionionotropic glutamate receptor binding
C0035494biological_processSNARE complex disassembly
C0042802molecular_functionidentical protein binding
C0043001biological_processGolgi to plasma membrane protein transport
C0044877molecular_functionprotein-containing complex binding
C0045732biological_processpositive regulation of protein catabolic process
C0046872molecular_functionmetal ion binding
C0140545molecular_functionATP-dependent protein disaggregase activity
D0000149molecular_functionSNARE binding
D0000166molecular_functionnucleotide binding
D0001921biological_processpositive regulation of receptor recycling
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005794cellular_componentGolgi apparatus
D0005795cellular_componentGolgi stack
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006813biological_processpotassium ion transport
D0006886biological_processintracellular protein transport
D0006891biological_processintra-Golgi vesicle-mediated transport
D0015031biological_processprotein transport
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017075molecular_functionsyntaxin-1 binding
D0019901molecular_functionprotein kinase binding
D0019905molecular_functionsyntaxin binding
D0030165molecular_functionPDZ domain binding
D0030496cellular_componentmidbody
D0035255molecular_functionionotropic glutamate receptor binding
D0035494biological_processSNARE complex disassembly
D0042802molecular_functionidentical protein binding
D0043001biological_processGolgi to plasma membrane protein transport
D0044877molecular_functionprotein-containing complex binding
D0045732biological_processpositive regulation of protein catabolic process
D0046872molecular_functionmetal ion binding
D0140545molecular_functionATP-dependent protein disaggregase activity
E0000149molecular_functionSNARE binding
E0000166molecular_functionnucleotide binding
E0001921biological_processpositive regulation of receptor recycling
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005794cellular_componentGolgi apparatus
E0005795cellular_componentGolgi stack
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006813biological_processpotassium ion transport
E0006886biological_processintracellular protein transport
E0006891biological_processintra-Golgi vesicle-mediated transport
E0015031biological_processprotein transport
E0016787molecular_functionhydrolase activity
E0016887molecular_functionATP hydrolysis activity
E0017075molecular_functionsyntaxin-1 binding
E0019901molecular_functionprotein kinase binding
E0019905molecular_functionsyntaxin binding
E0030165molecular_functionPDZ domain binding
E0030496cellular_componentmidbody
E0035255molecular_functionionotropic glutamate receptor binding
E0035494biological_processSNARE complex disassembly
E0042802molecular_functionidentical protein binding
E0043001biological_processGolgi to plasma membrane protein transport
E0044877molecular_functionprotein-containing complex binding
E0045732biological_processpositive regulation of protein catabolic process
E0046872molecular_functionmetal ion binding
E0140545molecular_functionATP-dependent protein disaggregase activity
F0000149molecular_functionSNARE binding
F0000166molecular_functionnucleotide binding
F0001921biological_processpositive regulation of receptor recycling
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005794cellular_componentGolgi apparatus
F0005795cellular_componentGolgi stack
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006813biological_processpotassium ion transport
F0006886biological_processintracellular protein transport
F0006891biological_processintra-Golgi vesicle-mediated transport
F0015031biological_processprotein transport
F0016787molecular_functionhydrolase activity
F0016887molecular_functionATP hydrolysis activity
F0017075molecular_functionsyntaxin-1 binding
F0019901molecular_functionprotein kinase binding
F0019905molecular_functionsyntaxin binding
F0030165molecular_functionPDZ domain binding
F0030496cellular_componentmidbody
F0035255molecular_functionionotropic glutamate receptor binding
F0035494biological_processSNARE complex disassembly
F0042802molecular_functionidentical protein binding
F0043001biological_processGolgi to plasma membrane protein transport
F0044877molecular_functionprotein-containing complex binding
F0045732biological_processpositive regulation of protein catabolic process
F0046872molecular_functionmetal ion binding
F0140545molecular_functionATP-dependent protein disaggregase activity
G0000149molecular_functionSNARE binding
G0001669cellular_componentacrosomal vesicle
G0001956biological_processpositive regulation of neurotransmitter secretion
G0005484molecular_functionSNAP receptor activity
G0005515molecular_functionprotein binding
G0005886cellular_componentplasma membrane
G0006836biological_processneurotransmitter transport
G0006886biological_processintracellular protein transport
G0006887biological_processexocytosis
G0006906biological_processvesicle fusion
G0008021cellular_componentsynaptic vesicle
G0008076cellular_componentvoltage-gated potassium channel complex
G0009629biological_processresponse to gravity
G0010701biological_processpositive regulation of norepinephrine secretion
G0010807biological_processregulation of synaptic vesicle priming
G0012505cellular_componentendomembrane system
G0016020cellular_componentmembrane
G0016079biological_processsynaptic vesicle exocytosis
G0016081biological_processsynaptic vesicle docking
G0016192biological_processvesicle-mediated transport
G0016925biological_processprotein sumoylation
G0017022molecular_functionmyosin binding
G0017156biological_processcalcium-ion regulated exocytosis
G0017157biological_processregulation of exocytosis
G0019855molecular_functioncalcium channel inhibitor activity
G0019869molecular_functionchloride channel inhibitor activity
G0019900molecular_functionkinase binding
G0030073biological_processinsulin secretion
G0030141cellular_componentsecretory granule
G0030424cellular_componentaxon
G0030672cellular_componentsynaptic vesicle membrane
G0030674molecular_functionprotein-macromolecule adaptor activity
G0031201cellular_componentSNARE complex
G0031410cellular_componentcytoplasmic vesicle
G0031965cellular_componentnuclear membrane
G0032028molecular_functionmyosin head/neck binding
G0032940biological_processsecretion by cell
G0032991cellular_componentprotein-containing complex
G0033605biological_processpositive regulation of catecholamine secretion
G0035493biological_processSNARE complex assembly
G0035494biological_processSNARE complex disassembly
G0042641cellular_componentactomyosin
G0042734cellular_componentpresynaptic membrane
G0042802molecular_functionidentical protein binding
G0043005cellular_componentneuron projection
G0043008molecular_functionATP-dependent protein binding
G0044325molecular_functiontransmembrane transporter binding
G0044877molecular_functionprotein-containing complex binding
G0045055biological_processregulated exocytosis
G0045202cellular_componentsynapse
G0045921biological_processpositive regulation of exocytosis
G0045956biological_processpositive regulation of calcium ion-dependent exocytosis
G0046879biological_processhormone secretion
G0048278biological_processvesicle docking
G0048306molecular_functioncalcium-dependent protein binding
G0048488biological_processsynaptic vesicle endocytosis
G0048787cellular_componentpresynaptic active zone membrane
G0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
G0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
G0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
G0072657biological_processprotein localization to membrane
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098793cellular_componentpresynapse
G0098815biological_processmodulation of excitatory postsynaptic potential
G0098839cellular_componentpostsynaptic density membrane
G0098978cellular_componentglutamatergic synapse
G1903530biological_processregulation of secretion by cell
G2000463biological_processpositive regulation of excitatory postsynaptic potential
H0000149molecular_functionSNARE binding
H0001669cellular_componentacrosomal vesicle
H0001956biological_processpositive regulation of neurotransmitter secretion
H0005484molecular_functionSNAP receptor activity
H0005515molecular_functionprotein binding
H0005886cellular_componentplasma membrane
H0006836biological_processneurotransmitter transport
H0006886biological_processintracellular protein transport
H0006887biological_processexocytosis
H0006906biological_processvesicle fusion
H0008021cellular_componentsynaptic vesicle
H0008076cellular_componentvoltage-gated potassium channel complex
H0009629biological_processresponse to gravity
H0010701biological_processpositive regulation of norepinephrine secretion
H0010807biological_processregulation of synaptic vesicle priming
H0012505cellular_componentendomembrane system
H0016020cellular_componentmembrane
H0016079biological_processsynaptic vesicle exocytosis
H0016081biological_processsynaptic vesicle docking
H0016192biological_processvesicle-mediated transport
H0016925biological_processprotein sumoylation
H0017022molecular_functionmyosin binding
H0017156biological_processcalcium-ion regulated exocytosis
H0017157biological_processregulation of exocytosis
H0019855molecular_functioncalcium channel inhibitor activity
H0019869molecular_functionchloride channel inhibitor activity
H0019900molecular_functionkinase binding
H0030073biological_processinsulin secretion
H0030141cellular_componentsecretory granule
H0030424cellular_componentaxon
H0030672cellular_componentsynaptic vesicle membrane
H0030674molecular_functionprotein-macromolecule adaptor activity
H0031201cellular_componentSNARE complex
H0031410cellular_componentcytoplasmic vesicle
H0031965cellular_componentnuclear membrane
H0032028molecular_functionmyosin head/neck binding
H0032940biological_processsecretion by cell
H0032991cellular_componentprotein-containing complex
H0033605biological_processpositive regulation of catecholamine secretion
H0035493biological_processSNARE complex assembly
H0035494biological_processSNARE complex disassembly
H0042641cellular_componentactomyosin
H0042734cellular_componentpresynaptic membrane
H0042802molecular_functionidentical protein binding
H0043005cellular_componentneuron projection
H0043008molecular_functionATP-dependent protein binding
H0044325molecular_functiontransmembrane transporter binding
H0044877molecular_functionprotein-containing complex binding
H0045055biological_processregulated exocytosis
H0045202cellular_componentsynapse
H0045921biological_processpositive regulation of exocytosis
H0045956biological_processpositive regulation of calcium ion-dependent exocytosis
H0046879biological_processhormone secretion
H0048278biological_processvesicle docking
H0048306molecular_functioncalcium-dependent protein binding
H0048488biological_processsynaptic vesicle endocytosis
H0048787cellular_componentpresynaptic active zone membrane
H0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
H0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
H0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
H0072657biological_processprotein localization to membrane
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098793cellular_componentpresynapse
H0098815biological_processmodulation of excitatory postsynaptic potential
H0098839cellular_componentpostsynaptic density membrane
H0098978cellular_componentglutamatergic synapse
H1903530biological_processregulation of secretion by cell
H2000463biological_processpositive regulation of excitatory postsynaptic potential
I0000149molecular_functionSNARE binding
I0001917cellular_componentphotoreceptor inner segment
I0005249molecular_functionvoltage-gated potassium channel activity
I0005484molecular_functionSNAP receptor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005768cellular_componentendosome
I0005802cellular_componenttrans-Golgi network
I0005856cellular_componentcytoskeleton
I0005886cellular_componentplasma membrane
I0005938cellular_componentcell cortex
I0006887biological_processexocytosis
I0007269biological_processneurotransmitter secretion
I0007409biological_processaxonogenesis
I0007616biological_processlong-term memory
I0007626biological_processlocomotory behavior
I0008021cellular_componentsynaptic vesicle
I0008076cellular_componentvoltage-gated potassium channel complex
I0008289molecular_functionlipid binding
I0008306biological_processassociative learning
I0010975biological_processregulation of neuron projection development
I0015629cellular_componentactin cytoskeleton
I0016020cellular_componentmembrane
I0016079biological_processsynaptic vesicle exocytosis
I0016082biological_processsynaptic vesicle priming
I0016197biological_processendosomal transport
I0017022molecular_functionmyosin binding
I0017075molecular_functionsyntaxin-1 binding
I0019904molecular_functionprotein domain specific binding
I0030027cellular_componentlamellipodium
I0030073biological_processinsulin secretion
I0030175cellular_componentfilopodium
I0030182biological_processneuron differentiation
I0030424cellular_componentaxon
I0030426cellular_componentgrowth cone
I0031083cellular_componentBLOC-1 complex
I0031201cellular_componentSNARE complex
I0031340biological_processpositive regulation of vesicle fusion
I0031629biological_processsynaptic vesicle fusion to presynaptic active zone membrane
I0031915biological_processpositive regulation of synaptic plasticity
I0031982cellular_componentvesicle
I0032024biological_processpositive regulation of insulin secretion
I0035493biological_processSNARE complex assembly
I0036477cellular_componentsomatodendritic compartment
I0042734cellular_componentpresynaptic membrane
I0043005cellular_componentneuron projection
I0043025cellular_componentneuronal cell body
I0043195cellular_componentterminal bouton
I0044295cellular_componentaxonal growth cone
I0044325molecular_functiontransmembrane transporter binding
I0045202cellular_componentsynapse
I0046887biological_processpositive regulation of hormone secretion
I0048306molecular_functioncalcium-dependent protein binding
I0048471cellular_componentperinuclear region of cytoplasm
I0048791biological_processcalcium ion-regulated exocytosis of neurotransmitter
I0051649biological_processestablishment of localization in cell
I0051963biological_processregulation of synapse assembly
I0060291biological_processlong-term synaptic potentiation
I0061025biological_processmembrane fusion
I0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
I0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
I0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
I0070201biological_processregulation of establishment of protein localization
I0071805biological_processpotassium ion transmembrane transport
I0097470cellular_componentribbon synapse
I0098693biological_processregulation of synaptic vesicle cycle
I0098888cellular_componentextrinsic component of presynaptic membrane
I0098978cellular_componentglutamatergic synapse
I0099525biological_processpresynaptic dense core vesicle exocytosis
I1903296biological_processpositive regulation of glutamate secretion, neurotransmission
I1990926biological_processshort-term synaptic potentiation
J0000149molecular_functionSNARE binding
J0005483molecular_functionsoluble NSF attachment protein activity
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005886cellular_componentplasma membrane
J0006886biological_processintracellular protein transport
J0007420biological_processbrain development
J0008021cellular_componentsynaptic vesicle
J0010807biological_processregulation of synaptic vesicle priming
J0015031biological_processprotein transport
J0016082biological_processsynaptic vesicle priming
J0016192biological_processvesicle-mediated transport
J0019905molecular_functionsyntaxin binding
J0030182biological_processneuron differentiation
J0030425cellular_componentdendrite
J0031410cellular_componentcytoplasmic vesicle
J0031594cellular_componentneuromuscular junction
J0032781biological_processpositive regulation of ATP-dependent activity
J0032984biological_processprotein-containing complex disassembly
J0035249biological_processsynaptic transmission, glutamatergic
J0035494biological_processSNARE complex disassembly
J0042599cellular_componentlamellar body
J0042734cellular_componentpresynaptic membrane
J0043195cellular_componentterminal bouton
J0043204cellular_componentperikaryon
J0044877molecular_functionprotein-containing complex binding
J0045176biological_processapical protein localization
J0045211cellular_componentpostsynaptic membrane
J0048787cellular_componentpresynaptic active zone membrane
J0055093biological_processresponse to hyperoxia
J0061025biological_processmembrane fusion
J0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
J0097060cellular_componentsynaptic membrane
J0098793cellular_componentpresynapse
J0098794cellular_componentpostsynapse
J0098978cellular_componentglutamatergic synapse
K0000149molecular_functionSNARE binding
K0005483molecular_functionsoluble NSF attachment protein activity
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005886cellular_componentplasma membrane
K0006886biological_processintracellular protein transport
K0007420biological_processbrain development
K0008021cellular_componentsynaptic vesicle
K0010807biological_processregulation of synaptic vesicle priming
K0015031biological_processprotein transport
K0016082biological_processsynaptic vesicle priming
K0016192biological_processvesicle-mediated transport
K0019905molecular_functionsyntaxin binding
K0030182biological_processneuron differentiation
K0030425cellular_componentdendrite
K0031410cellular_componentcytoplasmic vesicle
K0031594cellular_componentneuromuscular junction
K0032781biological_processpositive regulation of ATP-dependent activity
K0032984biological_processprotein-containing complex disassembly
K0035249biological_processsynaptic transmission, glutamatergic
K0035494biological_processSNARE complex disassembly
K0042599cellular_componentlamellar body
K0042734cellular_componentpresynaptic membrane
K0043195cellular_componentterminal bouton
K0043204cellular_componentperikaryon
K0044877molecular_functionprotein-containing complex binding
K0045176biological_processapical protein localization
K0045211cellular_componentpostsynaptic membrane
K0048787cellular_componentpresynaptic active zone membrane
K0055093biological_processresponse to hyperoxia
K0061025biological_processmembrane fusion
K0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
K0097060cellular_componentsynaptic membrane
K0098793cellular_componentpresynapse
K0098794cellular_componentpostsynapse
K0098978cellular_componentglutamatergic synapse
L0000149molecular_functionSNARE binding
L0005483molecular_functionsoluble NSF attachment protein activity
L0005515molecular_functionprotein binding
L0005739cellular_componentmitochondrion
L0005886cellular_componentplasma membrane
L0006886biological_processintracellular protein transport
L0007420biological_processbrain development
L0008021cellular_componentsynaptic vesicle
L0010807biological_processregulation of synaptic vesicle priming
L0015031biological_processprotein transport
L0016082biological_processsynaptic vesicle priming
L0016192biological_processvesicle-mediated transport
L0019905molecular_functionsyntaxin binding
L0030182biological_processneuron differentiation
L0030425cellular_componentdendrite
L0031410cellular_componentcytoplasmic vesicle
L0031594cellular_componentneuromuscular junction
L0032781biological_processpositive regulation of ATP-dependent activity
L0032984biological_processprotein-containing complex disassembly
L0035249biological_processsynaptic transmission, glutamatergic
L0035494biological_processSNARE complex disassembly
L0042599cellular_componentlamellar body
L0042734cellular_componentpresynaptic membrane
L0043195cellular_componentterminal bouton
L0043204cellular_componentperikaryon
L0044877molecular_functionprotein-containing complex binding
L0045176biological_processapical protein localization
L0045211cellular_componentpostsynaptic membrane
L0048787cellular_componentpresynaptic active zone membrane
L0055093biological_processresponse to hyperoxia
L0061025biological_processmembrane fusion
L0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
L0097060cellular_componentsynaptic membrane
L0098793cellular_componentpresynapse
L0098794cellular_componentpostsynapse
L0098978cellular_componentglutamatergic synapse
Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. IlVIgMTNrpdlIDeALl.R
ChainResidueDetails
AILE367-ARG385
site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
GARG198-VAL237
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9727495","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"9731775","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsModified residue: {"description":"Phosphoserine; by CDK16","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P46460","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46459","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues62
DetailsDomain: {"description":"t-SNARE coiled-coil homology 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues74
DetailsRegion: {"description":"Interaction with CENPF","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues22
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues19
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by PKC and PKA","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues3
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DB05","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P54920","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
ALYS549electrostatic stabiliser
ATHR550electrostatic stabiliser
AASP603electrostatic stabiliser
AASP604proton acceptor
ALYS631electrostatic stabiliser
ALYS708electrostatic stabiliser
site_idMCSA2
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
BLYS549electrostatic stabiliser
BTHR550electrostatic stabiliser
BASP603electrostatic stabiliser
BASP604proton acceptor
BLYS631electrostatic stabiliser
BLYS708electrostatic stabiliser
site_idMCSA3
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
CLYS549electrostatic stabiliser
CTHR550electrostatic stabiliser
CASP603electrostatic stabiliser
CASP604proton acceptor
CLYS631electrostatic stabiliser
CLYS708electrostatic stabiliser
site_idMCSA4
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
DLYS549electrostatic stabiliser
DTHR550electrostatic stabiliser
DASP603electrostatic stabiliser
DASP604proton acceptor
DLYS631electrostatic stabiliser
DLYS708electrostatic stabiliser
site_idMCSA5
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
ELYS549electrostatic stabiliser
ETHR550electrostatic stabiliser
EASP603electrostatic stabiliser
EASP604proton acceptor
ELYS631electrostatic stabiliser
ELYS708electrostatic stabiliser
site_idMCSA6
Number of Residues6
DetailsM-CSA 642
ChainResidueDetails
FLYS549electrostatic stabiliser
FTHR550electrostatic stabiliser
FASP603electrostatic stabiliser
FASP604proton acceptor
FLYS631electrostatic stabiliser
FLYS708electrostatic stabiliser

244349

PDB entries from 2025-11-05

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