9P8Z

Crystal Structure of GTP cyclohydrolase 1 (FolE) from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006730	biological_process	one-carbon metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006730	biological_process	one-carbon metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006730	biological_process	one-carbon metabolic process
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0006730	biological_process	one-carbon metabolic process
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0006730	biological_process	one-carbon metabolic process
F	0008270	molecular_function	zinc ion binding
F	0016787	molecular_function	hydrolase activity
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0006730	biological_process	one-carbon metabolic process
G	0008270	molecular_function	zinc ion binding
G	0016787	molecular_function	hydrolase activity
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0006730	biological_process	one-carbon metabolic process
H	0008270	molecular_function	zinc ion binding
H	0016787	molecular_function	hydrolase activity
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0006730	biological_process	one-carbon metabolic process
I	0008270	molecular_function	zinc ion binding
I	0016787	molecular_function	hydrolase activity
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0006730	biological_process	one-carbon metabolic process
J	0008270	molecular_function	zinc ion binding
J	0016787	molecular_function	hydrolase activity
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0003934	molecular_function	GTP cyclohydrolase I activity
K	0005525	molecular_function	GTP binding
K	0005737	cellular_component	cytoplasm
K	0006729	biological_process	tetrahydrobiopterin biosynthetic process
K	0006730	biological_process	one-carbon metabolic process
K	0008270	molecular_function	zinc ion binding
K	0016787	molecular_function	hydrolase activity
K	0046654	biological_process	tetrahydrofolate biosynthetic process
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0003934	molecular_function	GTP cyclohydrolase I activity
L	0005525	molecular_function	GTP binding
L	0005737	cellular_component	cytoplasm
L	0006729	biological_process	tetrahydrobiopterin biosynthetic process
L	0006730	biological_process	one-carbon metabolic process
L	0008270	molecular_function	zinc ion binding
L	0016787	molecular_function	hydrolase activity
L	0046654	biological_process	tetrahydrofolate biosynthetic process
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0003934	molecular_function	GTP cyclohydrolase I activity
M	0005525	molecular_function	GTP binding
M	0005737	cellular_component	cytoplasm
M	0006729	biological_process	tetrahydrobiopterin biosynthetic process
M	0006730	biological_process	one-carbon metabolic process
M	0008270	molecular_function	zinc ion binding
M	0016787	molecular_function	hydrolase activity
M	0046654	biological_process	tetrahydrofolate biosynthetic process
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0003934	molecular_function	GTP cyclohydrolase I activity
N	0005525	molecular_function	GTP binding
N	0005737	cellular_component	cytoplasm
N	0006729	biological_process	tetrahydrobiopterin biosynthetic process
N	0006730	biological_process	one-carbon metabolic process
N	0008270	molecular_function	zinc ion binding
N	0016787	molecular_function	hydrolase activity
N	0046654	biological_process	tetrahydrofolate biosynthetic process
N	0046872	molecular_function	metal ion binding
O	0000166	molecular_function	nucleotide binding
O	0003934	molecular_function	GTP cyclohydrolase I activity
O	0005525	molecular_function	GTP binding
O	0005737	cellular_component	cytoplasm
O	0006729	biological_process	tetrahydrobiopterin biosynthetic process
O	0006730	biological_process	one-carbon metabolic process
O	0008270	molecular_function	zinc ion binding
O	0016787	molecular_function	hydrolase activity
O	0046654	biological_process	tetrahydrofolate biosynthetic process
O	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0003934	molecular_function	GTP cyclohydrolase I activity
P	0005525	molecular_function	GTP binding
P	0005737	cellular_component	cytoplasm
P	0006729	biological_process	tetrahydrobiopterin biosynthetic process
P	0006730	biological_process	one-carbon metabolic process
P	0008270	molecular_function	zinc ion binding
P	0016787	molecular_function	hydrolase activity
P	0046654	biological_process	tetrahydrofolate biosynthetic process
P	0046872	molecular_function	metal ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0003934	molecular_function	GTP cyclohydrolase I activity
Q	0005525	molecular_function	GTP binding
Q	0005737	cellular_component	cytoplasm
Q	0006729	biological_process	tetrahydrobiopterin biosynthetic process
Q	0006730	biological_process	one-carbon metabolic process
Q	0008270	molecular_function	zinc ion binding
Q	0016787	molecular_function	hydrolase activity
Q	0046654	biological_process	tetrahydrofolate biosynthetic process
Q	0046872	molecular_function	metal ion binding
R	0000166	molecular_function	nucleotide binding
R	0003934	molecular_function	GTP cyclohydrolase I activity
R	0005525	molecular_function	GTP binding
R	0005737	cellular_component	cytoplasm
R	0006729	biological_process	tetrahydrobiopterin biosynthetic process
R	0006730	biological_process	one-carbon metabolic process
R	0008270	molecular_function	zinc ion binding
R	0016787	molecular_function	hydrolase activity
R	0046654	biological_process	tetrahydrofolate biosynthetic process
R	0046872	molecular_function	metal ion binding
S	0000166	molecular_function	nucleotide binding
S	0003934	molecular_function	GTP cyclohydrolase I activity
S	0005525	molecular_function	GTP binding
S	0005737	cellular_component	cytoplasm
S	0006729	biological_process	tetrahydrobiopterin biosynthetic process
S	0006730	biological_process	one-carbon metabolic process
S	0008270	molecular_function	zinc ion binding
S	0016787	molecular_function	hydrolase activity
S	0046654	biological_process	tetrahydrofolate biosynthetic process
S	0046872	molecular_function	metal ion binding
T	0000166	molecular_function	nucleotide binding
T	0003934	molecular_function	GTP cyclohydrolase I activity
T	0005525	molecular_function	GTP binding
T	0005737	cellular_component	cytoplasm
T	0006729	biological_process	tetrahydrobiopterin biosynthetic process
T	0006730	biological_process	one-carbon metabolic process
T	0008270	molecular_function	zinc ion binding
T	0016787	molecular_function	hydrolase activity
T	0046654	biological_process	tetrahydrofolate biosynthetic process
T	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. ELVlvKEIpmyStCEHH

Chain	Residue	Details
A	GLU77-HIS93

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site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. AkRpQVQERLT

Chain	Residue	Details
A	ALA127-THR137

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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