Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9P4W

Atomic model of wild type S. cerevisiae Fatty Acid Synthase (FAS)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004312	molecular_function	fatty acid synthase activity
A	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008410	molecular_function	CoA-transferase activity
A	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
A	0016409	molecular_function	palmitoyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0019367	biological_process	fatty acid elongation, saturated fatty acid
A	0030497	biological_process	fatty acid elongation
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016746	molecular_function	acyltransferase activity
B	0019367	biological_process	fatty acid elongation, saturated fatty acid
B	0030497	biological_process	fatty acid elongation
B	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005835	cellular_component	fatty acid synthase complex
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016746	molecular_function	acyltransferase activity
D	0019367	biological_process	fatty acid elongation, saturated fatty acid
D	0030497	biological_process	fatty acid elongation
D	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0004312	molecular_function	fatty acid synthase activity
E	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
E	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0004321	molecular_function	fatty-acyl-CoA synthase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005811	cellular_component	lipid droplet
E	0005829	cellular_component	cytosol
E	0005835	cellular_component	fatty acid synthase complex
E	0006633	biological_process	fatty acid biosynthetic process
E	0008410	molecular_function	CoA-transferase activity
E	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
E	0016409	molecular_function	palmitoyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0019367	biological_process	fatty acid elongation, saturated fatty acid
E	0030497	biological_process	fatty acid elongation
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
H	0000287	molecular_function	magnesium ion binding
H	0004312	molecular_function	fatty acid synthase activity
H	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
H	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
H	0004321	molecular_function	fatty-acyl-CoA synthase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0005835	cellular_component	fatty acid synthase complex
H	0006633	biological_process	fatty acid biosynthetic process
H	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
H	0016746	molecular_function	acyltransferase activity
H	0019367	biological_process	fatty acid elongation, saturated fatty acid
H	0030497	biological_process	fatty acid elongation
H	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006633	biological_process	fatty acid biosynthetic process
I	0008410	molecular_function	CoA-transferase activity
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0019367	biological_process	fatty acid elongation, saturated fatty acid
I	0030497	biological_process	fatty acid elongation
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0000287	molecular_function	magnesium ion binding
K	0004312	molecular_function	fatty acid synthase activity
K	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
K	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
K	0004321	molecular_function	fatty-acyl-CoA synthase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005829	cellular_component	cytosol
K	0005835	cellular_component	fatty acid synthase complex
K	0006633	biological_process	fatty acid biosynthetic process
K	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
K	0016746	molecular_function	acyltransferase activity
K	0019367	biological_process	fatty acid elongation, saturated fatty acid
K	0030497	biological_process	fatty acid elongation
K	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0004312	molecular_function	fatty acid synthase activity
L	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
L	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0004321	molecular_function	fatty-acyl-CoA synthase activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0005835	cellular_component	fatty acid synthase complex
L	0006633	biological_process	fatty acid biosynthetic process
L	0008410	molecular_function	CoA-transferase activity
L	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
L	0016409	molecular_function	palmitoyltransferase activity
L	0016740	molecular_function	transferase activity
L	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
L	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
L	0019367	biological_process	fatty acid elongation, saturated fatty acid
L	0030497	biological_process	fatty acid elongation
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
N	0000287	molecular_function	magnesium ion binding
N	0004312	molecular_function	fatty acid synthase activity
N	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
N	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
N	0004321	molecular_function	fatty-acyl-CoA synthase activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005829	cellular_component	cytosol
N	0005835	cellular_component	fatty acid synthase complex
N	0006633	biological_process	fatty acid biosynthetic process
N	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
N	0016746	molecular_function	acyltransferase activity
N	0019367	biological_process	fatty acid elongation, saturated fatty acid
N	0030497	biological_process	fatty acid elongation
N	0042759	biological_process	long-chain fatty acid biosynthetic process
O	0004312	molecular_function	fatty acid synthase activity
O	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
O	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
O	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O	0004321	molecular_function	fatty-acyl-CoA synthase activity
O	0005515	molecular_function	protein binding
O	0005737	cellular_component	cytoplasm
O	0005739	cellular_component	mitochondrion
O	0005811	cellular_component	lipid droplet
O	0005829	cellular_component	cytosol
O	0005835	cellular_component	fatty acid synthase complex
O	0006633	biological_process	fatty acid biosynthetic process
O	0008410	molecular_function	CoA-transferase activity
O	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
O	0016409	molecular_function	palmitoyltransferase activity
O	0016740	molecular_function	transferase activity
O	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
O	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
O	0019367	biological_process	fatty acid elongation, saturated fatty acid
O	0030497	biological_process	fatty acid elongation
O	0042759	biological_process	long-chain fatty acid biosynthetic process
O	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
Q	0000287	molecular_function	magnesium ion binding
Q	0004312	molecular_function	fatty acid synthase activity
Q	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
Q	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
Q	0004321	molecular_function	fatty-acyl-CoA synthase activity
Q	0005515	molecular_function	protein binding
Q	0005739	cellular_component	mitochondrion
Q	0005829	cellular_component	cytosol
Q	0005835	cellular_component	fatty acid synthase complex
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
Q	0016746	molecular_function	acyltransferase activity
Q	0019367	biological_process	fatty acid elongation, saturated fatty acid
Q	0030497	biological_process	fatty acid elongation
Q	0042759	biological_process	long-chain fatty acid biosynthetic process
R	0004312	molecular_function	fatty acid synthase activity
R	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
R	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
R	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
R	0004321	molecular_function	fatty-acyl-CoA synthase activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005811	cellular_component	lipid droplet
R	0005829	cellular_component	cytosol
R	0005835	cellular_component	fatty acid synthase complex
R	0006633	biological_process	fatty acid biosynthetic process
R	0008410	molecular_function	CoA-transferase activity
R	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
R	0016409	molecular_function	palmitoyltransferase activity
R	0016740	molecular_function	transferase activity
R	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
R	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
R	0019367	biological_process	fatty acid elongation, saturated fatty acid
R	0030497	biological_process	fatty acid elongation
R	0042759	biological_process	long-chain fatty acid biosynthetic process
R	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	750
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2328
Details	Region: {"description":"Enoyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2892
Details	Region: {"description":"Dehydratase"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1194
Details	Region: {"description":"Beta-ketoacyl reductase"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)