9P4V

Atomic model of wild type S. cerevisiae Fatty Acid Synthase (FAS) in complex with Palmitoyl-CoA (in vitro binding)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000287	molecular_function	magnesium ion binding
1	0004312	molecular_function	fatty acid synthase activity
1	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
1	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
1	0004321	molecular_function	fatty-acyl-CoA synthase activity
1	0005515	molecular_function	protein binding
1	0005739	cellular_component	mitochondrion
1	0005829	cellular_component	cytosol
1	0005835	cellular_component	fatty acid synthase complex
1	0006633	biological_process	fatty acid biosynthetic process
1	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
1	0016746	molecular_function	acyltransferase activity
1	0019367	biological_process	fatty acid elongation, saturated fatty acid
1	0030497	biological_process	fatty acid elongation
1	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0004312	molecular_function	fatty acid synthase activity
A	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
A	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0004321	molecular_function	fatty-acyl-CoA synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005835	cellular_component	fatty acid synthase complex
A	0006633	biological_process	fatty acid biosynthetic process
A	0008410	molecular_function	CoA-transferase activity
A	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
A	0016409	molecular_function	palmitoyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0019367	biological_process	fatty acid elongation, saturated fatty acid
A	0030497	biological_process	fatty acid elongation
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0000287	molecular_function	magnesium ion binding
B	0004312	molecular_function	fatty acid synthase activity
B	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
B	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
B	0004321	molecular_function	fatty-acyl-CoA synthase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005835	cellular_component	fatty acid synthase complex
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016746	molecular_function	acyltransferase activity
B	0019367	biological_process	fatty acid elongation, saturated fatty acid
B	0030497	biological_process	fatty acid elongation
B	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0004312	molecular_function	fatty acid synthase activity
C	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
C	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0004321	molecular_function	fatty-acyl-CoA synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0005835	cellular_component	fatty acid synthase complex
C	0006633	biological_process	fatty acid biosynthetic process
C	0008410	molecular_function	CoA-transferase activity
C	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
C	0016409	molecular_function	palmitoyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0019367	biological_process	fatty acid elongation, saturated fatty acid
C	0030497	biological_process	fatty acid elongation
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0000287	molecular_function	magnesium ion binding
D	0004312	molecular_function	fatty acid synthase activity
D	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
D	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
D	0004321	molecular_function	fatty-acyl-CoA synthase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005835	cellular_component	fatty acid synthase complex
D	0006633	biological_process	fatty acid biosynthetic process
D	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
D	0016746	molecular_function	acyltransferase activity
D	0019367	biological_process	fatty acid elongation, saturated fatty acid
D	0030497	biological_process	fatty acid elongation
D	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0004312	molecular_function	fatty acid synthase activity
I	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
I	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0004321	molecular_function	fatty-acyl-CoA synthase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005811	cellular_component	lipid droplet
I	0005829	cellular_component	cytosol
I	0005835	cellular_component	fatty acid synthase complex
I	0006633	biological_process	fatty acid biosynthetic process
I	0008410	molecular_function	CoA-transferase activity
I	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
I	0016409	molecular_function	palmitoyltransferase activity
I	0016740	molecular_function	transferase activity
I	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0019367	biological_process	fatty acid elongation, saturated fatty acid
I	0030497	biological_process	fatty acid elongation
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0000287	molecular_function	magnesium ion binding
J	0004312	molecular_function	fatty acid synthase activity
J	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
J	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
J	0004321	molecular_function	fatty-acyl-CoA synthase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0005835	cellular_component	fatty acid synthase complex
J	0006633	biological_process	fatty acid biosynthetic process
J	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
J	0016746	molecular_function	acyltransferase activity
J	0019367	biological_process	fatty acid elongation, saturated fatty acid
J	0030497	biological_process	fatty acid elongation
J	0042759	biological_process	long-chain fatty acid biosynthetic process
N	0004312	molecular_function	fatty acid synthase activity
N	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
N	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
N	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N	0004321	molecular_function	fatty-acyl-CoA synthase activity
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005739	cellular_component	mitochondrion
N	0005811	cellular_component	lipid droplet
N	0005829	cellular_component	cytosol
N	0005835	cellular_component	fatty acid synthase complex
N	0006633	biological_process	fatty acid biosynthetic process
N	0008410	molecular_function	CoA-transferase activity
N	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
N	0016409	molecular_function	palmitoyltransferase activity
N	0016740	molecular_function	transferase activity
N	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
N	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
N	0019367	biological_process	fatty acid elongation, saturated fatty acid
N	0030497	biological_process	fatty acid elongation
N	0042759	biological_process	long-chain fatty acid biosynthetic process
N	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
O	0000287	molecular_function	magnesium ion binding
O	0004312	molecular_function	fatty acid synthase activity
O	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
O	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
O	0004321	molecular_function	fatty-acyl-CoA synthase activity
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005829	cellular_component	cytosol
O	0005835	cellular_component	fatty acid synthase complex
O	0006633	biological_process	fatty acid biosynthetic process
O	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
O	0016746	molecular_function	acyltransferase activity
O	0019367	biological_process	fatty acid elongation, saturated fatty acid
O	0030497	biological_process	fatty acid elongation
O	0042759	biological_process	long-chain fatty acid biosynthetic process
T	0004312	molecular_function	fatty acid synthase activity
T	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
T	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
T	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
T	0004321	molecular_function	fatty-acyl-CoA synthase activity
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005739	cellular_component	mitochondrion
T	0005811	cellular_component	lipid droplet
T	0005829	cellular_component	cytosol
T	0005835	cellular_component	fatty acid synthase complex
T	0006633	biological_process	fatty acid biosynthetic process
T	0008410	molecular_function	CoA-transferase activity
T	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
T	0016409	molecular_function	palmitoyltransferase activity
T	0016740	molecular_function	transferase activity
T	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
T	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
T	0019367	biological_process	fatty acid elongation, saturated fatty acid
T	0030497	biological_process	fatty acid elongation
T	0042759	biological_process	long-chain fatty acid biosynthetic process
T	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity
U	0000287	molecular_function	magnesium ion binding
U	0004312	molecular_function	fatty acid synthase activity
U	0004315	molecular_function	3-oxoacyl-[acyl-carrier-protein] synthase activity
U	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
U	0004321	molecular_function	fatty-acyl-CoA synthase activity
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005829	cellular_component	cytosol
U	0005835	cellular_component	fatty acid synthase complex
U	0006633	biological_process	fatty acid biosynthetic process
U	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
U	0016746	molecular_function	acyltransferase activity
U	0019367	biological_process	fatty acid elongation, saturated fatty acid
U	0030497	biological_process	fatty acid elongation
U	0042759	biological_process	long-chain fatty acid biosynthetic process
Z	0004312	molecular_function	fatty acid synthase activity
Z	0004313	molecular_function	[acyl-carrier-protein] S-acetyltransferase activity
Z	0004314	molecular_function	[acyl-carrier-protein] S-malonyltransferase activity
Z	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Z	0004321	molecular_function	fatty-acyl-CoA synthase activity
Z	0005515	molecular_function	protein binding
Z	0005737	cellular_component	cytoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005811	cellular_component	lipid droplet
Z	0005829	cellular_component	cytosol
Z	0005835	cellular_component	fatty acid synthase complex
Z	0006633	biological_process	fatty acid biosynthetic process
Z	0008410	molecular_function	CoA-transferase activity
Z	0016297	molecular_function	fatty acyl-[ACP] hydrolase activity
Z	0016409	molecular_function	palmitoyltransferase activity
Z	0016740	molecular_function	transferase activity
Z	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
Z	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Z	0019367	biological_process	fatty acid elongation, saturated fatty acid
Z	0030497	biological_process	fatty acid elongation
Z	0042759	biological_process	long-chain fatty acid biosynthetic process
Z	0141148	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADPH) activity

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. LVGGKSTVQNEILGDL

Chain	Residue	Details
B	LEU175-LEU190

---

site_id	PS00606
Number of Residues	17
Details	KS3_1 Ketosynthase family 3 (KS3) active site signature. GPIktPVgACATSveSV

Chain	Residue	Details
B	GLY1296-VAL1312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	750
Details	Domain: {"description":"MaoC-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2328
Details	Region: {"description":"Enoyl reductase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2892
Details	Region: {"description":"Dehydratase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1308
Details	Region: {"description":"Malonyl/palmitoyl transferase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Active site: {"description":"For acetyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Active site: {"description":"For malonyltransferase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1194
Details	Region: {"description":"Beta-ketoacyl reductase"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	18
Details	Active site: {"description":"For beta-ketoacyl synthase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01348","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---