9OZ8
Cryo-EM structure of chicken NEL dimer bound with one human NICOL.
Functional Information from PROSITE/UniProt
| site_id | PS00010 |
| Number of Residues | 12 |
| Details | ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CvNtpgsFmCiC |
| Chain | Residue | Details |
| B | CYS457-CYS468 | |
| B | CYS572-CYS583 | |
| B | CYS619-CYS630 |
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CaCpqGftGPsC |
| Chain | Residue | Details |
| B | CYS541-CYS552 |
| site_id | PS01186 |
| Number of Residues | 15 |
| Details | EGF_2 EGF-like domain signature 2. CiCktGYiriddys.C |
| Chain | Residue | Details |
| B | CYS466-CYS480 | |
| B | CYS508-CYS521 | |
| B | CYS541-CYS552 | |
| B | CYS663-CYS677 |
| site_id | PS01187 |
| Number of Residues | 27 |
| Details | EGF_CA Calcium-binding EGF-like domain signature. DvDECaegqhy........Crentm..CvNtpgsFmC |
| Chain | Residue | Details |
| B | ASP440-CYS466 | |
| B | ASP555-CYS581 | |
| B | ASP602-CYS628 |
| site_id | PS01208 |
| Number of Residues | 40 |
| Details | VWFC_1 VWFC domain signature. Ckn.CTCmngtvq........CealiCslsd......Cppnsalsyvdgk....CCke..C |
| Chain | Residue | Details |
| B | CYS291-CYS330 | |
| B | CYS719-CYS755 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 326 |
| Details | Domain: {"description":"Laminin G-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 118 |
| Details | Domain: {"description":"VWFC 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00220","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 82 |
| Details | Domain: {"description":"EGF-like 2; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 80 |
| Details | Domain: {"description":"EGF-like 3; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 60 |
| Details | Domain: {"description":"EGF-like 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 92 |
| Details | Domain: {"description":"EGF-like 5; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 110 |
| Details | Domain: {"description":"VWFC 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00220","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 116 |
| Details | Domain: {"description":"VWFC 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00220","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 13 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EGF-like 6; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
