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9OTQ

Human glutamine synthetase filament apo

Functional Information from GO Data
ChainGOidnamespacecontents
a0003824molecular_functioncatalytic activity
a0004356molecular_functionglutamine synthetase activity
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005739cellular_componentmitochondrion
a0005829cellular_componentcytosol
a0005886cellular_componentplasma membrane
a0006538biological_processL-glutamate catabolic process
a0006542biological_processobsolete glutamine biosynthetic process
a0008283biological_processcell population proliferation
a0010594biological_processregulation of endothelial cell migration
a0018345biological_processprotein palmitoylation
a0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
a0042254biological_processribosome biogenesis
a0042802molecular_functionidentical protein binding
a0045648biological_processpositive regulation of erythrocyte differentiation
a0070062cellular_componentextracellular exosome
a0097275biological_processintracellular ammonium homeostasis
a1901704biological_processL-glutamine biosynthetic process
a1903670biological_processregulation of sprouting angiogenesis
a1904749biological_processregulation of protein localization to nucleolus
b0003824molecular_functioncatalytic activity
b0004356molecular_functionglutamine synthetase activity
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005739cellular_componentmitochondrion
b0005829cellular_componentcytosol
b0005886cellular_componentplasma membrane
b0006538biological_processL-glutamate catabolic process
b0006542biological_processobsolete glutamine biosynthetic process
b0008283biological_processcell population proliferation
b0010594biological_processregulation of endothelial cell migration
b0018345biological_processprotein palmitoylation
b0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
b0042254biological_processribosome biogenesis
b0042802molecular_functionidentical protein binding
b0045648biological_processpositive regulation of erythrocyte differentiation
b0070062cellular_componentextracellular exosome
b0097275biological_processintracellular ammonium homeostasis
b1901704biological_processL-glutamine biosynthetic process
b1903670biological_processregulation of sprouting angiogenesis
b1904749biological_processregulation of protein localization to nucleolus
c0003824molecular_functioncatalytic activity
c0004356molecular_functionglutamine synthetase activity
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005739cellular_componentmitochondrion
c0005829cellular_componentcytosol
c0005886cellular_componentplasma membrane
c0006538biological_processL-glutamate catabolic process
c0006542biological_processobsolete glutamine biosynthetic process
c0008283biological_processcell population proliferation
c0010594biological_processregulation of endothelial cell migration
c0018345biological_processprotein palmitoylation
c0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
c0042254biological_processribosome biogenesis
c0042802molecular_functionidentical protein binding
c0045648biological_processpositive regulation of erythrocyte differentiation
c0070062cellular_componentextracellular exosome
c0097275biological_processintracellular ammonium homeostasis
c1901704biological_processL-glutamine biosynthetic process
c1903670biological_processregulation of sprouting angiogenesis
c1904749biological_processregulation of protein localization to nucleolus
d0003824molecular_functioncatalytic activity
d0004356molecular_functionglutamine synthetase activity
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005739cellular_componentmitochondrion
d0005829cellular_componentcytosol
d0005886cellular_componentplasma membrane
d0006538biological_processL-glutamate catabolic process
d0006542biological_processobsolete glutamine biosynthetic process
d0008283biological_processcell population proliferation
d0010594biological_processregulation of endothelial cell migration
d0018345biological_processprotein palmitoylation
d0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
d0042254biological_processribosome biogenesis
d0042802molecular_functionidentical protein binding
d0045648biological_processpositive regulation of erythrocyte differentiation
d0070062cellular_componentextracellular exosome
d0097275biological_processintracellular ammonium homeostasis
d1901704biological_processL-glutamine biosynthetic process
d1903670biological_processregulation of sprouting angiogenesis
d1904749biological_processregulation of protein localization to nucleolus
e0003824molecular_functioncatalytic activity
e0004356molecular_functionglutamine synthetase activity
e0005515molecular_functionprotein binding
e0005634cellular_componentnucleus
e0005739cellular_componentmitochondrion
e0005829cellular_componentcytosol
e0005886cellular_componentplasma membrane
e0006538biological_processL-glutamate catabolic process
e0006542biological_processobsolete glutamine biosynthetic process
e0008283biological_processcell population proliferation
e0010594biological_processregulation of endothelial cell migration
e0018345biological_processprotein palmitoylation
e0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
e0042254biological_processribosome biogenesis
e0042802molecular_functionidentical protein binding
e0045648biological_processpositive regulation of erythrocyte differentiation
e0070062cellular_componentextracellular exosome
e0097275biological_processintracellular ammonium homeostasis
e1901704biological_processL-glutamine biosynthetic process
e1903670biological_processregulation of sprouting angiogenesis
e1904749biological_processregulation of protein localization to nucleolus
L0003824molecular_functioncatalytic activity
L0004356molecular_functionglutamine synthetase activity
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006538biological_processL-glutamate catabolic process
L0006542biological_processobsolete glutamine biosynthetic process
L0008283biological_processcell population proliferation
L0010594biological_processregulation of endothelial cell migration
L0018345biological_processprotein palmitoylation
L0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
L0042254biological_processribosome biogenesis
L0042802molecular_functionidentical protein binding
L0045648biological_processpositive regulation of erythrocyte differentiation
L0070062cellular_componentextracellular exosome
L0097275biological_processintracellular ammonium homeostasis
L1901704biological_processL-glutamine biosynthetic process
L1903670biological_processregulation of sprouting angiogenesis
L1904749biological_processregulation of protein localization to nucleolus
M0003824molecular_functioncatalytic activity
M0004356molecular_functionglutamine synthetase activity
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006538biological_processL-glutamate catabolic process
M0006542biological_processobsolete glutamine biosynthetic process
M0008283biological_processcell population proliferation
M0010594biological_processregulation of endothelial cell migration
M0018345biological_processprotein palmitoylation
M0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
M0042254biological_processribosome biogenesis
M0042802molecular_functionidentical protein binding
M0045648biological_processpositive regulation of erythrocyte differentiation
M0070062cellular_componentextracellular exosome
M0097275biological_processintracellular ammonium homeostasis
M1901704biological_processL-glutamine biosynthetic process
M1903670biological_processregulation of sprouting angiogenesis
M1904749biological_processregulation of protein localization to nucleolus
N0003824molecular_functioncatalytic activity
N0004356molecular_functionglutamine synthetase activity
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0006538biological_processL-glutamate catabolic process
N0006542biological_processobsolete glutamine biosynthetic process
N0008283biological_processcell population proliferation
N0010594biological_processregulation of endothelial cell migration
N0018345biological_processprotein palmitoylation
N0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
N0042254biological_processribosome biogenesis
N0042802molecular_functionidentical protein binding
N0045648biological_processpositive regulation of erythrocyte differentiation
N0070062cellular_componentextracellular exosome
N0097275biological_processintracellular ammonium homeostasis
N1901704biological_processL-glutamine biosynthetic process
N1903670biological_processregulation of sprouting angiogenesis
N1904749biological_processregulation of protein localization to nucleolus
O0003824molecular_functioncatalytic activity
O0004356molecular_functionglutamine synthetase activity
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005739cellular_componentmitochondrion
O0005829cellular_componentcytosol
O0005886cellular_componentplasma membrane
O0006538biological_processL-glutamate catabolic process
O0006542biological_processobsolete glutamine biosynthetic process
O0008283biological_processcell population proliferation
O0010594biological_processregulation of endothelial cell migration
O0018345biological_processprotein palmitoylation
O0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
O0042254biological_processribosome biogenesis
O0042802molecular_functionidentical protein binding
O0045648biological_processpositive regulation of erythrocyte differentiation
O0070062cellular_componentextracellular exosome
O0097275biological_processintracellular ammonium homeostasis
O1901704biological_processL-glutamine biosynthetic process
O1903670biological_processregulation of sprouting angiogenesis
O1904749biological_processregulation of protein localization to nucleolus
P0003824molecular_functioncatalytic activity
P0004356molecular_functionglutamine synthetase activity
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005739cellular_componentmitochondrion
P0005829cellular_componentcytosol
P0005886cellular_componentplasma membrane
P0006538biological_processL-glutamate catabolic process
P0006542biological_processobsolete glutamine biosynthetic process
P0008283biological_processcell population proliferation
P0010594biological_processregulation of endothelial cell migration
P0018345biological_processprotein palmitoylation
P0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
P0042254biological_processribosome biogenesis
P0042802molecular_functionidentical protein binding
P0045648biological_processpositive regulation of erythrocyte differentiation
P0070062cellular_componentextracellular exosome
P0097275biological_processintracellular ammonium homeostasis
P1901704biological_processL-glutamine biosynthetic process
P1903670biological_processregulation of sprouting angiogenesis
P1904749biological_processregulation of protein localization to nucleolus
Q0003824molecular_functioncatalytic activity
Q0004356molecular_functionglutamine synthetase activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005739cellular_componentmitochondrion
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006538biological_processL-glutamate catabolic process
Q0006542biological_processobsolete glutamine biosynthetic process
Q0008283biological_processcell population proliferation
Q0010594biological_processregulation of endothelial cell migration
Q0018345biological_processprotein palmitoylation
Q0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
Q0042254biological_processribosome biogenesis
Q0042802molecular_functionidentical protein binding
Q0045648biological_processpositive regulation of erythrocyte differentiation
Q0070062cellular_componentextracellular exosome
Q0097275biological_processintracellular ammonium homeostasis
Q1901704biological_processL-glutamine biosynthetic process
Q1903670biological_processregulation of sprouting angiogenesis
Q1904749biological_processregulation of protein localization to nucleolus
R0003824molecular_functioncatalytic activity
R0004356molecular_functionglutamine synthetase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005739cellular_componentmitochondrion
R0005829cellular_componentcytosol
R0005886cellular_componentplasma membrane
R0006538biological_processL-glutamate catabolic process
R0006542biological_processobsolete glutamine biosynthetic process
R0008283biological_processcell population proliferation
R0010594biological_processregulation of endothelial cell migration
R0018345biological_processprotein palmitoylation
R0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
R0042254biological_processribosome biogenesis
R0042802molecular_functionidentical protein binding
R0045648biological_processpositive regulation of erythrocyte differentiation
R0070062cellular_componentextracellular exosome
R0097275biological_processintracellular ammonium homeostasis
R1901704biological_processL-glutamine biosynthetic process
R1903670biological_processregulation of sprouting angiogenesis
R1904749biological_processregulation of protein localization to nucleolus
S0003824molecular_functioncatalytic activity
S0004356molecular_functionglutamine synthetase activity
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005739cellular_componentmitochondrion
S0005829cellular_componentcytosol
S0005886cellular_componentplasma membrane
S0006538biological_processL-glutamate catabolic process
S0006542biological_processobsolete glutamine biosynthetic process
S0008283biological_processcell population proliferation
S0010594biological_processregulation of endothelial cell migration
S0018345biological_processprotein palmitoylation
S0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
S0042254biological_processribosome biogenesis
S0042802molecular_functionidentical protein binding
S0045648biological_processpositive regulation of erythrocyte differentiation
S0070062cellular_componentextracellular exosome
S0097275biological_processintracellular ammonium homeostasis
S1901704biological_processL-glutamine biosynthetic process
S1903670biological_processregulation of sprouting angiogenesis
S1904749biological_processregulation of protein localization to nucleolus
T0003824molecular_functioncatalytic activity
T0004356molecular_functionglutamine synthetase activity
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005739cellular_componentmitochondrion
T0005829cellular_componentcytosol
T0005886cellular_componentplasma membrane
T0006538biological_processL-glutamate catabolic process
T0006542biological_processobsolete glutamine biosynthetic process
T0008283biological_processcell population proliferation
T0010594biological_processregulation of endothelial cell migration
T0018345biological_processprotein palmitoylation
T0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
T0042254biological_processribosome biogenesis
T0042802molecular_functionidentical protein binding
T0045648biological_processpositive regulation of erythrocyte differentiation
T0070062cellular_componentextracellular exosome
T0097275biological_processintracellular ammonium homeostasis
T1901704biological_processL-glutamine biosynthetic process
T1903670biological_processregulation of sprouting angiogenesis
T1904749biological_processregulation of protein localization to nucleolus
U0003824molecular_functioncatalytic activity
U0004356molecular_functionglutamine synthetase activity
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005739cellular_componentmitochondrion
U0005829cellular_componentcytosol
U0005886cellular_componentplasma membrane
U0006538biological_processL-glutamate catabolic process
U0006542biological_processobsolete glutamine biosynthetic process
U0008283biological_processcell population proliferation
U0010594biological_processregulation of endothelial cell migration
U0018345biological_processprotein palmitoylation
U0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
U0042254biological_processribosome biogenesis
U0042802molecular_functionidentical protein binding
U0045648biological_processpositive regulation of erythrocyte differentiation
U0070062cellular_componentextracellular exosome
U0097275biological_processintracellular ammonium homeostasis
U1901704biological_processL-glutamine biosynthetic process
U1903670biological_processregulation of sprouting angiogenesis
U1904749biological_processregulation of protein localization to nucleolus
V0003824molecular_functioncatalytic activity
V0004356molecular_functionglutamine synthetase activity
V0005515molecular_functionprotein binding
V0005634cellular_componentnucleus
V0005739cellular_componentmitochondrion
V0005829cellular_componentcytosol
V0005886cellular_componentplasma membrane
V0006538biological_processL-glutamate catabolic process
V0006542biological_processobsolete glutamine biosynthetic process
V0008283biological_processcell population proliferation
V0010594biological_processregulation of endothelial cell migration
V0018345biological_processprotein palmitoylation
V0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
V0042254biological_processribosome biogenesis
V0042802molecular_functionidentical protein binding
V0045648biological_processpositive regulation of erythrocyte differentiation
V0070062cellular_componentextracellular exosome
V0097275biological_processintracellular ammonium homeostasis
V1901704biological_processL-glutamine biosynthetic process
V1903670biological_processregulation of sprouting angiogenesis
V1904749biological_processregulation of protein localization to nucleolus
W0003824molecular_functioncatalytic activity
W0004356molecular_functionglutamine synthetase activity
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005739cellular_componentmitochondrion
W0005829cellular_componentcytosol
W0005886cellular_componentplasma membrane
W0006538biological_processL-glutamate catabolic process
W0006542biological_processobsolete glutamine biosynthetic process
W0008283biological_processcell population proliferation
W0010594biological_processregulation of endothelial cell migration
W0018345biological_processprotein palmitoylation
W0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
W0042254biological_processribosome biogenesis
W0042802molecular_functionidentical protein binding
W0045648biological_processpositive regulation of erythrocyte differentiation
W0070062cellular_componentextracellular exosome
W0097275biological_processintracellular ammonium homeostasis
W1901704biological_processL-glutamine biosynthetic process
W1903670biological_processregulation of sprouting angiogenesis
W1904749biological_processregulation of protein localization to nucleolus
X0003824molecular_functioncatalytic activity
X0004356molecular_functionglutamine synthetase activity
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005739cellular_componentmitochondrion
X0005829cellular_componentcytosol
X0005886cellular_componentplasma membrane
X0006538biological_processL-glutamate catabolic process
X0006542biological_processobsolete glutamine biosynthetic process
X0008283biological_processcell population proliferation
X0010594biological_processregulation of endothelial cell migration
X0018345biological_processprotein palmitoylation
X0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
X0042254biological_processribosome biogenesis
X0042802molecular_functionidentical protein binding
X0045648biological_processpositive regulation of erythrocyte differentiation
X0070062cellular_componentextracellular exosome
X0097275biological_processintracellular ammonium homeostasis
X1901704biological_processL-glutamine biosynthetic process
X1903670biological_processregulation of sprouting angiogenesis
X1904749biological_processregulation of protein localization to nucleolus
Y0003824molecular_functioncatalytic activity
Y0004356molecular_functionglutamine synthetase activity
Y0005515molecular_functionprotein binding
Y0005634cellular_componentnucleus
Y0005739cellular_componentmitochondrion
Y0005829cellular_componentcytosol
Y0005886cellular_componentplasma membrane
Y0006538biological_processL-glutamate catabolic process
Y0006542biological_processobsolete glutamine biosynthetic process
Y0008283biological_processcell population proliferation
Y0010594biological_processregulation of endothelial cell migration
Y0018345biological_processprotein palmitoylation
Y0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
Y0042254biological_processribosome biogenesis
Y0042802molecular_functionidentical protein binding
Y0045648biological_processpositive regulation of erythrocyte differentiation
Y0070062cellular_componentextracellular exosome
Y0097275biological_processintracellular ammonium homeostasis
Y1901704biological_processL-glutamine biosynthetic process
Y1903670biological_processregulation of sprouting angiogenesis
Y1904749biological_processregulation of protein localization to nucleolus
Z0003824molecular_functioncatalytic activity
Z0004356molecular_functionglutamine synthetase activity
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005739cellular_componentmitochondrion
Z0005829cellular_componentcytosol
Z0005886cellular_componentplasma membrane
Z0006538biological_processL-glutamate catabolic process
Z0006542biological_processobsolete glutamine biosynthetic process
Z0008283biological_processcell population proliferation
Z0010594biological_processregulation of endothelial cell migration
Z0018345biological_processprotein palmitoylation
Z0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
Z0042254biological_processribosome biogenesis
Z0042802molecular_functionidentical protein binding
Z0045648biological_processpositive regulation of erythrocyte differentiation
Z0070062cellular_componentextracellular exosome
Z0097275biological_processintracellular ammonium homeostasis
Z1901704biological_processL-glutamine biosynthetic process
Z1903670biological_processregulation of sprouting angiogenesis
Z1904749biological_processregulation of protein localization to nucleolus
Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStlqsegs.NSDmyL
ChainResidueDetails
LPHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
LLYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1640
DetailsDomain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues460
DetailsRegion: {"description":"Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation","evidences":[{"source":"PubMed","id":"26990986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38579670","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues120
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues200
DetailsBinding site: {"evidences":[{"source":"PDB","id":"2OJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QC8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues60
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues20
DetailsModified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues40
DetailsModified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"26990986","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues20
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues20
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

254227

PDB entries from 2026-05-27

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