9OPR
TMPRSS2 S441A in complex with the H1H7 Fab and anti-kappa light chain nanobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000794 | cellular_component | condensed nuclear chromosome |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005940 | cellular_component | septin ring |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0031386 | molecular_function | protein tag activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044389 | molecular_function | ubiquitin-like protein ligase binding |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VTAAHC |
| Chain | Residue | Details |
| A | VAL292-CYS297 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
| Chain | Residue | Details |
| H | TYR201-HIS207 | |
| L | TYR192-HIS198 |
| site_id | PS01209 |
| Number of Residues | 23 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CInpsnw.CDgvsHCpgg.EDEnr...C |
| Chain | Residue | Details |
| A | CYS126-CYS148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 93 |
| Details | Domain: {"description":"SRCR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00196","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 130 |
| Details | Region: {"description":"HKU1-CoV S protein-binding","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964328","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11245484","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38964326","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7XYD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y0F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HD8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8S0M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
