9ON2

Cryo-EM structure of a tetrameric XRCC3-RAD51C-RAD51D-XRCC2 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000400	molecular_function	four-way junction DNA binding
A	0000722	biological_process	telomere maintenance via recombination
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000781	cellular_component	chromosome, telomeric region
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005657	cellular_component	replication fork
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0008821	molecular_function	crossover junction DNA endonuclease activity
A	0010824	biological_process	regulation of centrosome duplication
A	0031297	biological_process	replication fork processing
A	0033065	cellular_component	Rad51C-XRCC3 complex
A	0036297	biological_process	interstrand cross-link repair
A	0043596	cellular_component	nuclear replication fork
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0071140	biological_process	resolution of mitotic recombination intermediates
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0090656	biological_process	t-circle formation
A	0090657	biological_process	telomeric loop disassembly
A	0090737	biological_process	telomere maintenance via telomere trimming
C	0000400	molecular_function	four-way junction DNA binding
C	0000707	biological_process	meiotic DNA recombinase assembly
C	0000722	biological_process	telomere maintenance via recombination
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005657	cellular_component	replication fork
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0007062	biological_process	sister chromatid cohesion
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0031297	biological_process	replication fork processing
C	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
C	0033065	cellular_component	Rad51C-XRCC3 complex
C	0043596	cellular_component	nuclear replication fork
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0097435	biological_process	supramolecular fiber organization
D	0000400	molecular_function	four-way junction DNA binding
D	0000722	biological_process	telomere maintenance via recombination
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005657	cellular_component	replication fork
D	0005813	cellular_component	centrosome
D	0005815	cellular_component	microtubule organizing center
D	0006281	biological_process	DNA repair
D	0007131	biological_process	reciprocal meiotic recombination
D	0008094	molecular_function	ATP-dependent activity, acting on DNA
D	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
D	0042148	biological_process	DNA strand invasion
D	0043015	molecular_function	gamma-tubulin binding
D	0097435	biological_process	supramolecular fiber organization
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
X	0000278	biological_process	mitotic cell cycle
X	0000400	molecular_function	four-way junction DNA binding
X	0000724	biological_process	double-strand break repair via homologous recombination
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005657	cellular_component	replication fork
X	0005813	cellular_component	centrosome
X	0006281	biological_process	DNA repair
X	0007098	biological_process	centrosome cycle
X	0033063	cellular_component	Rad51B-Rad51C-Rad51D-XRCC2 complex
X	0042148	biological_process	DNA strand invasion
X	0051321	biological_process	meiotic cell cycle
X	0097435	biological_process	supramolecular fiber organization

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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