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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9OMZ

Cryo-EM structure of a pentameric RAD51-XRCC3-RAD51C-RAD51D-XRCC2 (51-X3CDX2) complex.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000400molecular_functionfour-way junction DNA binding
A0000722biological_processtelomere maintenance via recombination
A0000724biological_processdouble-strand break repair via homologous recombination
A0000781cellular_componentchromosome, telomeric region
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005657cellular_componentreplication fork
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
A0006974biological_processDNA damage response
A0008821molecular_functioncrossover junction DNA endonuclease activity
A0010824biological_processregulation of centrosome duplication
A0031297biological_processreplication fork processing
A0033065cellular_componentRad51C-XRCC3 complex
A0036297biological_processinterstrand cross-link repair
A0043596cellular_componentnuclear replication fork
A0045003biological_processdouble-strand break repair via synthesis-dependent strand annealing
A0048471cellular_componentperinuclear region of cytoplasm
A0071140biological_processresolution of mitotic recombination intermediates
A0090267biological_processpositive regulation of mitotic cell cycle spindle assembly checkpoint
A0090656biological_processt-circle formation
A0090657biological_processtelomeric loop disassembly
A0090737biological_processtelomere maintenance via telomere trimming
A0140664molecular_functionATP-dependent DNA damage sensor activity
B0000150molecular_functionDNA strand exchange activity
B0000152cellular_componentnuclear ubiquitin ligase complex
B0000166molecular_functionnucleotide binding
B0000228cellular_componentnuclear chromosome
B0000722biological_processtelomere maintenance via recombination
B0000724biological_processdouble-strand break repair via homologous recombination
B0000730biological_processDNA recombinase assembly
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0000793cellular_componentcondensed chromosome
B0000794cellular_componentcondensed nuclear chromosome
B0000800cellular_componentlateral element
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003690molecular_functiondouble-stranded DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0006259biological_processDNA metabolic process
B0006281biological_processDNA repair
B0006310biological_processDNA recombination
B0006312biological_processmitotic recombination
B0006974biological_processDNA damage response
B0007127biological_processmeiosis I
B0007131biological_processreciprocal meiotic recombination
B0008094molecular_functionATP-dependent activity, acting on DNA
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0010165biological_processresponse to X-ray
B0010569biological_processregulation of double-strand break repair via homologous recombination
B0010833biological_processtelomere maintenance via telomere lengthening
B0016605cellular_componentPML body
B0016887molecular_functionATP hydrolysis activity
B0019899molecular_functionenzyme binding
B0031297biological_processreplication fork processing
B0031491molecular_functionnucleosome binding
B0032991cellular_componentprotein-containing complex
B0032993cellular_componentprotein-DNA complex
B0035861cellular_componentsite of double-strand break
B0036297biological_processinterstrand cross-link repair
B0042148biological_processDNA strand invasion
B0042802molecular_functionidentical protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0051321biological_processmeiotic cell cycle
B0070182molecular_functionDNA polymerase binding
B0070192biological_processchromosome organization involved in meiotic cell cycle
B0071479biological_processcellular response to ionizing radiation
B0071480biological_processcellular response to gamma radiation
B0072719biological_processcellular response to cisplatin
B0072757biological_processcellular response to camptothecin
B0099182cellular_componentpresynaptic intermediate filament cytoskeleton
B0140664molecular_functionATP-dependent DNA damage sensor activity
B1904631biological_processresponse to glucoside
B1990426biological_processmitotic recombination-dependent replication fork processing
B1990918biological_processdouble-strand break repair involved in meiotic recombination
B2000001biological_processregulation of DNA damage checkpoint
C0000400molecular_functionfour-way junction DNA binding
C0000707biological_processmeiotic DNA recombinase assembly
C0000722biological_processtelomere maintenance via recombination
C0000724biological_processdouble-strand break repair via homologous recombination
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005657cellular_componentreplication fork
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006310biological_processDNA recombination
C0007062biological_processsister chromatid cohesion
C0007131biological_processreciprocal meiotic recombination
C0008821molecular_functioncrossover junction DNA endonuclease activity
C0010971biological_processpositive regulation of G2/M transition of mitotic cell cycle
C0031297biological_processreplication fork processing
C0033063cellular_componentRad51B-Rad51C-Rad51D-XRCC2 complex
C0033065cellular_componentRad51C-XRCC3 complex
C0043596cellular_componentnuclear replication fork
C0048471cellular_componentperinuclear region of cytoplasm
C0097435biological_processsupramolecular fiber organization
C0140664molecular_functionATP-dependent DNA damage sensor activity
D0000400molecular_functionfour-way junction DNA binding
D0000722biological_processtelomere maintenance via recombination
D0000723biological_processtelomere maintenance
D0000724biological_processdouble-strand break repair via homologous recombination
D0000781cellular_componentchromosome, telomeric region
D0003677molecular_functionDNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005657cellular_componentreplication fork
D0005813cellular_componentcentrosome
D0005815cellular_componentmicrotubule organizing center
D0006281biological_processDNA repair
D0007131biological_processreciprocal meiotic recombination
D0008094molecular_functionATP-dependent activity, acting on DNA
D0033063cellular_componentRad51B-Rad51C-Rad51D-XRCC2 complex
D0042148biological_processDNA strand invasion
D0043015molecular_functiongamma-tubulin binding
D0097435biological_processsupramolecular fiber organization
D0140664molecular_functionATP-dependent DNA damage sensor activity
X0000278biological_processmitotic cell cycle
X0000400molecular_functionfour-way junction DNA binding
X0000724biological_processdouble-strand break repair via homologous recombination
X0003677molecular_functionDNA binding
X0005515molecular_functionprotein binding
X0005524molecular_functionATP binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005657cellular_componentreplication fork
X0005813cellular_componentcentrosome
X0006281biological_processDNA repair
X0007098biological_processcentrosome cycle
X0033063cellular_componentRad51B-Rad51C-Rad51D-XRCC2 complex
X0042148biological_processDNA strand invasion
X0051321biological_processmeiotic cell cycle
X0097435biological_processsupramolecular fiber organization
X0140664molecular_functionATP-dependent DNA damage sensor activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues21
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues29
DetailsDomain: {"description":"HhH"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues73
DetailsRegion: {"description":"Interaction with PALB2"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues15
DetailsMotif: {"description":"Nuclear export signal; masked by the interaction with BRCA2","evidences":[{"source":"PubMed","id":"24013206","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29507080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NWL","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"9461559","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38509361","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by CHEK1","evidences":[{"source":"PubMed","id":"15665856","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27941124","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23393192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27941124","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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